Radiosensitization by Hyperthermia Critically Depends on the Time Interval
Copyright © 2023 Elsevier Inc. All rights reserved..
PURPOSE: Hyperthermia is a potent sensitizer of radiation therapy that improves both tumor control and survival in women with locally advanced cervical cancer (LACC). The optimal sequence and interval between hyperthermia and radiation therapy are still under debate.
METHODS AND MATERIALS: We investigated the interval and sequence in vitro in cervical cancer cell lines, patient-derived organoids, and SiHa cervical cancer hind leg xenografts in athymic nude mice and compared the results with retrospective results from 58 women with LACC treated with thermoradiotherapy.
RESULTS: All 3 approaches confirmed that shortening the interval between hyperthermia and radiation therapy enhanced hyperthermic radiosensitization by 2 to 8 times more DNA double-strand breaks and apoptosis and 10 to 100 times lower cell survival, delayed tumor growth in mice, and increased the 5-year survival rate of women with LACC from 22% (interval ≥80 minutes) to 54% (interval <80 minutes). In vitro and in vivo results showed that the sequence of hyperthermia and radiation therapy did not affect the outcome.
CONCLUSIONS: Shortening the interval between hyperthermia and radiation therapy significantly improves treatment outcomes. The sequence of hyperthermia and radiation therapy (before or after) does not seem to matter.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:118 |
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| Enthalten in: |
International journal of radiation oncology, biology, physics - 118(2024), 3 vom: 01. Feb., Seite 817-828 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mei, Xionge [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 14.02.2024 Date Revised 14.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijrobp.2023.09.048 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM363138188 |
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| 500 | |a Date Revised 14.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier Inc. All rights reserved. | ||
| 520 | |a PURPOSE: Hyperthermia is a potent sensitizer of radiation therapy that improves both tumor control and survival in women with locally advanced cervical cancer (LACC). The optimal sequence and interval between hyperthermia and radiation therapy are still under debate | ||
| 520 | |a METHODS AND MATERIALS: We investigated the interval and sequence in vitro in cervical cancer cell lines, patient-derived organoids, and SiHa cervical cancer hind leg xenografts in athymic nude mice and compared the results with retrospective results from 58 women with LACC treated with thermoradiotherapy | ||
| 520 | |a RESULTS: All 3 approaches confirmed that shortening the interval between hyperthermia and radiation therapy enhanced hyperthermic radiosensitization by 2 to 8 times more DNA double-strand breaks and apoptosis and 10 to 100 times lower cell survival, delayed tumor growth in mice, and increased the 5-year survival rate of women with LACC from 22% (interval ≥80 minutes) to 54% (interval <80 minutes). In vitro and in vivo results showed that the sequence of hyperthermia and radiation therapy did not affect the outcome | ||
| 520 | |a CONCLUSIONS: Shortening the interval between hyperthermia and radiation therapy significantly improves treatment outcomes. The sequence of hyperthermia and radiation therapy (before or after) does not seem to matter | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Kok, H Petra |e verfasserin |4 aut | |
| 700 | 1 | |a Rodermond, Hans M |e verfasserin |4 aut | |
| 700 | 1 | |a van Bochove, Gregor G W |e verfasserin |4 aut | |
| 700 | 1 | |a Snoek, Barbara C |e verfasserin |4 aut | |
| 700 | 1 | |a van Leeuwen, Caspar M |e verfasserin |4 aut | |
| 700 | 1 | |a Franken, Nicolaas A P |e verfasserin |4 aut | |
| 700 | 1 | |a Ten Hagen, Timo L M |e verfasserin |4 aut | |
| 700 | 1 | |a Crezee, Johannes |e verfasserin |4 aut | |
| 700 | 1 | |a Vermeulen, Louis |e verfasserin |4 aut | |
| 700 | 1 | |a Stalpers, Lukas J A |e verfasserin |4 aut | |
| 700 | 1 | |a Oei, Arlene L |e verfasserin |4 aut | |
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