Spexin level in acute myocardial infarction in the emergency department
2023 Yahya Çiftçi, Mehtap Gurger, Evrim Gul, Mustafa Yilmaz, Selda Telo, Metin Atescelik, Goktekin Mehmet Cagri, Kobat Mehmet Ali, published by CEON/CEES..
Background: We aimed to determine the serum spexin level in patients with acute myocardial infarction (AMI) admitted to the emergency department.
Methods: A total of 100 patients with AMI (50 with ST-segment elevation myocardial infarction (STEMI) and 50 with non-ST-segment elevation myocardial infarction (NSTEMI)) and 50 control group patients with non-cardiac chest pain were included in the study. A detailed anamnesis was taken, a physical examination was performed, and 12-lead electrocardiograms and venous blood samples were taken at the time of admission. Spexin levels were measured via enzyme-linked immunosorbent assay.
Results: Serum spexin levels were significantly lower in the AMI group than in the non-cardiac chest pain group (p<0.001). There was no significant difference in serum spexin levels between STEMI and NSTEMI patients (p=0.83). In receiver operating curve analysis, we detected 58% sensitivity, 76% specificity, 82.9% positive predictive value, and 47.5% negative predictive value with an optimal cutoff value of 532 pg/mL for the diagnosis of AMI.
Conclusions: In this study, serum spexin levels were significantly lower in AMI patients compared to patients with non-cardiac chest pain. The decrease in spexin levels suggests that it has the potential to be used as a diagnostic marker in AMI patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:42 |
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| Enthalten in: |
Journal of medical biochemistry - 42(2023), 3 vom: 25. Aug., Seite 407-411 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Çiftçi, Yahya [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 31.10.2023 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.5937/jomb0-39485 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 500 | |a Date Revised 31.10.2023 | ||
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a 2023 Yahya Çiftçi, Mehtap Gurger, Evrim Gul, Mustafa Yilmaz, Selda Telo, Metin Atescelik, Goktekin Mehmet Cagri, Kobat Mehmet Ali, published by CEON/CEES. | ||
| 520 | |a Background: We aimed to determine the serum spexin level in patients with acute myocardial infarction (AMI) admitted to the emergency department | ||
| 520 | |a Methods: A total of 100 patients with AMI (50 with ST-segment elevation myocardial infarction (STEMI) and 50 with non-ST-segment elevation myocardial infarction (NSTEMI)) and 50 control group patients with non-cardiac chest pain were included in the study. A detailed anamnesis was taken, a physical examination was performed, and 12-lead electrocardiograms and venous blood samples were taken at the time of admission. Spexin levels were measured via enzyme-linked immunosorbent assay | ||
| 520 | |a Results: Serum spexin levels were significantly lower in the AMI group than in the non-cardiac chest pain group (p<0.001). There was no significant difference in serum spexin levels between STEMI and NSTEMI patients (p=0.83). In receiver operating curve analysis, we detected 58% sensitivity, 76% specificity, 82.9% positive predictive value, and 47.5% negative predictive value with an optimal cutoff value of 532 pg/mL for the diagnosis of AMI | ||
| 520 | |a Conclusions: In this study, serum spexin levels were significantly lower in AMI patients compared to patients with non-cardiac chest pain. The decrease in spexin levels suggests that it has the potential to be used as a diagnostic marker in AMI patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a acute myocardial infarction | |
| 650 | 4 | |a diagnosis | |
| 650 | 4 | |a spexin | |
| 700 | 1 | |a Gurger, Mehtap |e verfasserin |4 aut | |
| 700 | 1 | |a Gul, Evrim |e verfasserin |4 aut | |
| 700 | 1 | |a Yilmaz, Mustafa |e verfasserin |4 aut | |
| 700 | 1 | |a Telo, Selda |e verfasserin |4 aut | |
| 700 | 1 | |a Atescelik, Metin |e verfasserin |4 aut | |
| 700 | 1 | |a Cagri, Goktekin Mehmet |e verfasserin |4 aut | |
| 700 | 1 | |a Ali, Kobat Mehmet |e verfasserin |4 aut | |
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