Acute liver failure due to hepatitis A virus presented with Guillain-Barré syndrome and ocular myasthenia gravis
© BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ..
Hepatitis A is one of the most common causes of acute viral hepatitis in children. Immunological manifestations involving the nervous system are rare with hepatitis A infection. We report a case of a toddler who presented with acute liver failure secondary to hepatitis A infection. The child showed clinical and laboratory improvement initially with conservative management. However, after the initial improvement, she developed acute-onset ptosis along with areflexia. Serological and neurophysiological tests revealed the occurrence of ocular variant Guillain-Barré syndrome and ocular myasthenia gravis, which was only partially responsive to treatment (intravenous immunoglobulin and pyridostigmine). A sudden clinical deterioration was noted after the onset of ptosis. She succumbed on day 40 of hospitalisation due to hospital-acquired infection along with the primary hepatic pathology. This is a rare coincidental presentation of acute viral hepatitis A infection with autoimmune manifestations.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
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| Enthalten in: |
BMJ case reports - 16(2023), 10 vom: 09. Okt. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ks, Aswanth [VerfasserIn] |
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| Links: |
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| Themen: |
Case Reports |
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| Anmerkungen: |
Date Completed 13.10.2023 Date Revised 13.10.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1136/bcr-2023-254855 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM363067124 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ. | ||
| 520 | |a Hepatitis A is one of the most common causes of acute viral hepatitis in children. Immunological manifestations involving the nervous system are rare with hepatitis A infection. We report a case of a toddler who presented with acute liver failure secondary to hepatitis A infection. The child showed clinical and laboratory improvement initially with conservative management. However, after the initial improvement, she developed acute-onset ptosis along with areflexia. Serological and neurophysiological tests revealed the occurrence of ocular variant Guillain-Barré syndrome and ocular myasthenia gravis, which was only partially responsive to treatment (intravenous immunoglobulin and pyridostigmine). A sudden clinical deterioration was noted after the onset of ptosis. She succumbed on day 40 of hospitalisation due to hospital-acquired infection along with the primary hepatic pathology. This is a rare coincidental presentation of acute viral hepatitis A infection with autoimmune manifestations | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Hepatitis and other GI infections | |
| 650 | 4 | |a Hepatitis other | |
| 650 | 4 | |a Immunology | |
| 650 | 4 | |a Paediatric intensive care | |
| 700 | 1 | |a Kumar, Vinod |e verfasserin |4 aut | |
| 700 | 1 | |a Ms, Akhil Raj |e verfasserin |4 aut | |
| 700 | 1 | |a Bhat, Nowneet Kumar |e verfasserin |4 aut | |
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