Relationship between clinical-epidemiological parameters and outcomes of patients with COVID-19 admitted to the intensive care unit : a report from a Brazilian hospital
Copyright © 2023 D’Carmo Sodré, dos Santos, Povoas, Guzmán, Junqueira, Trindade, Gadelha, Romano, da Conceição, Gross, Silva, Rezende, Fontana, da Mata, Marin and de Carvalho..
Background: People in low-income countries, especially those with low socio-economic conditions, are likelier to test positive for SARS-CoV-2. The unequal conditions of public health systems also increase the infection rate and make early identification and treatment of at-risk patients difficult. Here, we aimed to characterize the epidemiological profile of COVID-19 patients in intensive care and identify laboratory and clinical markers associated with death.
Materials and methods: We conducted an observational, descriptive, and cross-sectional study in a reference hospital for COVID-19 treatment in the Southern Region of Bahia State, in Brazil, to evaluate the epidemiological, clinical, and laboratory characteristics of COVID-19 patients admitted to the intensive care unit (ICU). Additionally, we used the area under the curve (AUC) to classify survivors and non-survivors and a multivariate logistic regression analysis to assess factors associated with death. Data was collected from the hospital databases between April 2020 and July 2021.
Results: The use of bladder catheters (OR 79.30; p < 0.0001) and central venous catheters (OR, 45.12; p < 0.0001) were the main factors associated with death in ICU COVID-19 patients. Additionally, the number of non-survivors increased with age (p < 0.0001) and prolonged ICU stay (p < 0.0001). Besides, SAPS3 presents a higher sensibility (77.9%) and specificity (63.1%) to discriminate between survivors and non-survivor with an AUC of 0.79 (p < 0.0001).
Conclusion: We suggest that multi-laboratory parameters can predict patient prognosis and guide healthcare teams toward more assertive clinical management, better resource allocation, and improved survival of COVID-19 patients admitted to the ICU.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
|---|---|
| Enthalten in: |
Frontiers in public health - 11(2023) vom: 12., Seite 1241444 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
D'Carmo Sodré, Maisah Meyhr [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Biomarkers |
|---|
| Anmerkungen: |
Date Completed 10.10.2023 Date Revised 18.10.2023 published: Electronic-eCollection Citation Status MEDLINE |
|---|
| doi: |
10.3389/fpubh.2023.1241444 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM363021736 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM363021736 | ||
| 003 | DE-627 | ||
| 005 | 20231226092452.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3389/fpubh.2023.1241444 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1210.xml |
| 035 | |a (DE-627)NLM363021736 | ||
| 035 | |a (NLM)37808991 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a D'Carmo Sodré, Maisah Meyhr |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Relationship between clinical-epidemiological parameters and outcomes of patients with COVID-19 admitted to the intensive care unit |b a report from a Brazilian hospital |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 10.10.2023 | ||
| 500 | |a Date Revised 18.10.2023 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 D’Carmo Sodré, dos Santos, Povoas, Guzmán, Junqueira, Trindade, Gadelha, Romano, da Conceição, Gross, Silva, Rezende, Fontana, da Mata, Marin and de Carvalho. | ||
| 520 | |a Background: People in low-income countries, especially those with low socio-economic conditions, are likelier to test positive for SARS-CoV-2. The unequal conditions of public health systems also increase the infection rate and make early identification and treatment of at-risk patients difficult. Here, we aimed to characterize the epidemiological profile of COVID-19 patients in intensive care and identify laboratory and clinical markers associated with death | ||
| 520 | |a Materials and methods: We conducted an observational, descriptive, and cross-sectional study in a reference hospital for COVID-19 treatment in the Southern Region of Bahia State, in Brazil, to evaluate the epidemiological, clinical, and laboratory characteristics of COVID-19 patients admitted to the intensive care unit (ICU). Additionally, we used the area under the curve (AUC) to classify survivors and non-survivors and a multivariate logistic regression analysis to assess factors associated with death. Data was collected from the hospital databases between April 2020 and July 2021 | ||
| 520 | |a Results: The use of bladder catheters (OR 79.30; p < 0.0001) and central venous catheters (OR, 45.12; p < 0.0001) were the main factors associated with death in ICU COVID-19 patients. Additionally, the number of non-survivors increased with age (p < 0.0001) and prolonged ICU stay (p < 0.0001). Besides, SAPS3 presents a higher sensibility (77.9%) and specificity (63.1%) to discriminate between survivors and non-survivor with an AUC of 0.79 (p < 0.0001) | ||
| 520 | |a Conclusion: We suggest that multi-laboratory parameters can predict patient prognosis and guide healthcare teams toward more assertive clinical management, better resource allocation, and improved survival of COVID-19 patients admitted to the ICU | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a SAPS3 | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a biomarkers | |
| 650 | 4 | |a catheter | |
| 650 | 4 | |a epidemiology | |
| 650 | 4 | |a in-hospital mortality | |
| 650 | 4 | |a intensive care unit | |
| 700 | 1 | |a Dos Santos, Uener Ribeiro |e verfasserin |4 aut | |
| 700 | 1 | |a Povoas, Heitor Portella |e verfasserin |4 aut | |
| 700 | 1 | |a Guzmán, Júlio Lenin |e verfasserin |4 aut | |
| 700 | 1 | |a Junqueira, Caroline |e verfasserin |4 aut | |
| 700 | 1 | |a Trindade, Tayana Oliveira |e verfasserin |4 aut | |
| 700 | 1 | |a Gadelha, Sandra Rocha |e verfasserin |4 aut | |
| 700 | 1 | |a Romano, Carla Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a da Conceição, Aline Oliveira |e verfasserin |4 aut | |
| 700 | 1 | |a Gross, Eduardo |e verfasserin |4 aut | |
| 700 | 1 | |a Silva, Aline |e verfasserin |4 aut | |
| 700 | 1 | |a Rezende, Rachel Passos |e verfasserin |4 aut | |
| 700 | 1 | |a Fontana, Renato |e verfasserin |4 aut | |
| 700 | 1 | |a da Mata, Camila Pacheco Silveira Martins |e verfasserin |4 aut | |
| 700 | 1 | |a Marin, Lauro Juliano |e verfasserin |4 aut | |
| 700 | 1 | |a de Carvalho, Luciana Debortoli |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Frontiers in public health |d 2013 |g 11(2023) vom: 12., Seite 1241444 |w (DE-627)NLM23377548X |x 2296-2565 |7 nnns |
| 773 | 1 | 8 | |g volume:11 |g year:2023 |g day:12 |g pages:1241444 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3389/fpubh.2023.1241444 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 11 |j 2023 |b 12 |h 1241444 | ||