Porphyromonas gingivalis infection in the oral cavity is associated with elevated galactose-deficient IgA1 and increased nephritis severity in IgA nephropathy
© 2023. The Author(s), under exclusive licence to Japanese Society of Nephrology..
BACKGROUND: The relationship between the major periodontal bacteria, Porphyromonas gingivalis, and the pathogenesis of IgA nephropathy (IgAN)-particularly with respect to galactose-deficient IgA1 (Gd-IgA1)-has not been fully elucidated.
METHODS: Saliva samples from 30 IgAN patients and 44 patients with chronic kidney disease (CKD) were subjected to analysis of P. gingivalis status via polymerase chain reaction using a set of P. gingivalis-specific primers. The associations between P. gingivalis presence and clinical parameters, including plasma Gd-IgA1, were analyzed in each group.
RESULTS: Compared with the CKD group, the IgAN group demonstrated significantly higher plasma Gd-IgA1 levels (p < 0.05). Compared with the P. gingivalis-negative subgroup, the P. gingivalis-positive subgroup exhibited significantly higher plasma Gd-IgA1 levels in both IgAN and CKD patients (p < 0.05). Additionally, among IgAN patients, the P. gingivalis-positive subgroup displayed significantly higher plasma Gd-IgA1 and urine protein levels, compared with the P. gingivalis-negative subgroup (p < 0.05). With respect to renal biopsy findings, the frequencies of segmental glomerulosclerosis and tubular atrophy/interstitial fibrosis were significantly greater in the P. gingivalis-positive subgroup than in the P. gingivalis-negative subgroup, according to the Oxford classification of IgAN (p < 0.05).
CONCLUSION: Our findings suggest an association between the presence of P. gingivalis in the oral cavity and the pathogenesis of IgAN, mediated by increased levels of Gd-IgA1.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
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| Enthalten in: |
Clinical and experimental nephrology - 28(2024), 3 vom: 20. Feb., Seite 192-200 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ito, Seigo [VerfasserIn] |
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| Links: |
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| Themen: |
Cnm-positive S. mutans |
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| Anmerkungen: |
Date Completed 22.02.2024 Date Revised 22.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s10157-023-02411-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM363005633 |
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| 245 | 1 | 0 | |a Porphyromonas gingivalis infection in the oral cavity is associated with elevated galactose-deficient IgA1 and increased nephritis severity in IgA nephropathy |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s), under exclusive licence to Japanese Society of Nephrology. | ||
| 520 | |a BACKGROUND: The relationship between the major periodontal bacteria, Porphyromonas gingivalis, and the pathogenesis of IgA nephropathy (IgAN)-particularly with respect to galactose-deficient IgA1 (Gd-IgA1)-has not been fully elucidated | ||
| 520 | |a METHODS: Saliva samples from 30 IgAN patients and 44 patients with chronic kidney disease (CKD) were subjected to analysis of P. gingivalis status via polymerase chain reaction using a set of P. gingivalis-specific primers. The associations between P. gingivalis presence and clinical parameters, including plasma Gd-IgA1, were analyzed in each group | ||
| 520 | |a RESULTS: Compared with the CKD group, the IgAN group demonstrated significantly higher plasma Gd-IgA1 levels (p < 0.05). Compared with the P. gingivalis-negative subgroup, the P. gingivalis-positive subgroup exhibited significantly higher plasma Gd-IgA1 levels in both IgAN and CKD patients (p < 0.05). Additionally, among IgAN patients, the P. gingivalis-positive subgroup displayed significantly higher plasma Gd-IgA1 and urine protein levels, compared with the P. gingivalis-negative subgroup (p < 0.05). With respect to renal biopsy findings, the frequencies of segmental glomerulosclerosis and tubular atrophy/interstitial fibrosis were significantly greater in the P. gingivalis-positive subgroup than in the P. gingivalis-negative subgroup, according to the Oxford classification of IgAN (p < 0.05) | ||
| 520 | |a CONCLUSION: Our findings suggest an association between the presence of P. gingivalis in the oral cavity and the pathogenesis of IgAN, mediated by increased levels of Gd-IgA1 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cnm-positive S. mutans | |
| 650 | 4 | |a Dental caries | |
| 650 | 4 | |a Galactose-deficient IgA1 | |
| 650 | 4 | |a IgA nephropathy | |
| 650 | 4 | |a P. gingivalis | |
| 650 | 4 | |a Periodontal disease | |
| 650 | 7 | |a galactosyl-deficient IgA1 |2 NLM | |
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| 650 | 7 | |a Immunoglobulin A |2 NLM | |
| 700 | 1 | |a Misaki, Taro |e verfasserin |4 aut | |
| 700 | 1 | |a Nagasawa, Yasuyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Nomura, Ryota |e verfasserin |4 aut | |
| 700 | 1 | |a Naka, Shuhei |e verfasserin |4 aut | |
| 700 | 1 | |a Fukunaga, Akiko |e verfasserin |4 aut | |
| 700 | 1 | |a Matsuoka, Daiki |e verfasserin |4 aut | |
| 700 | 1 | |a Matayoshi, Saaya |e verfasserin |4 aut | |
| 700 | 1 | |a Matsumoto-Nakano, Michiyo |e verfasserin |4 aut | |
| 700 | 1 | |a Nakano, Kazuhiko |e verfasserin |4 aut | |
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