Serum levels of soluble suppression of tumorigenicity 2 (sST2) and heart-type fatty acid binding protein (H-FABP) independently predict in-hospital mortality in geriatric patients with COVID-19
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved..
Elevation of cardiac damage biomarkers is associated with adverse clinical outcomes and increased mortality in COVID-19 patients. This study assessed the association of admission serum levels of sST2 and H-FABP with in-hospital mortality in 191 geriatric patients (median age 86 yrs., IQR 82-91 yrs.) with COVID-19 and available measures of hs-cTnT and NT-proBNP at admission. Cox proportional hazards models were utilized to predict in-hospital mortality, considering clinical/biochemical confounders as covariates. A composite cardiac score was calculated to improve predictive accuracy. Patients deceased during their hospital stay (26%) exhibited higher levels of all biomarkers, which demonstrated good discrimination for in-hospital mortality. Addition of sST2 and H-FABP significantly improved the discriminatory power of hs-cTnT and NT-proBNP. The composite cardiac score (AUC=0.866) further enhanced the predictive accuracy. Crude and adjusted Cox regressions models revealed that both sST2 and H-FABP were independently associated with in-hospital mortality (HR for sST2 ≥129 ng/mL, 4.32 [1.48-12.59]; HR for H-FABP ≥18 ng/mL, 7.70 [2.12-28.01]). The composite cardiac score also independently correlated with in-hospital mortality (HR for 1-unit increase, 1.47 [1.14-1.90]). In older patients with COVID-19, sST2 and H-FABP demonstrated prognostic value, improving the predictive accuracy of the routinely assessed biomarkers hs-cTnT and NT-proBNP.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:216 |
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| Enthalten in: |
Mechanisms of ageing and development - 216(2023) vom: 15. Dez., Seite 111876 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sabbatinelli, Jacopo [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 21.12.2023 Date Revised 21.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.mad.2023.111876 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM362960933 |
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| 100 | 1 | |a Sabbatinelli, Jacopo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Serum levels of soluble suppression of tumorigenicity 2 (sST2) and heart-type fatty acid binding protein (H-FABP) independently predict in-hospital mortality in geriatric patients with COVID-19 |
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| 520 | |a Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a Elevation of cardiac damage biomarkers is associated with adverse clinical outcomes and increased mortality in COVID-19 patients. This study assessed the association of admission serum levels of sST2 and H-FABP with in-hospital mortality in 191 geriatric patients (median age 86 yrs., IQR 82-91 yrs.) with COVID-19 and available measures of hs-cTnT and NT-proBNP at admission. Cox proportional hazards models were utilized to predict in-hospital mortality, considering clinical/biochemical confounders as covariates. A composite cardiac score was calculated to improve predictive accuracy. Patients deceased during their hospital stay (26%) exhibited higher levels of all biomarkers, which demonstrated good discrimination for in-hospital mortality. Addition of sST2 and H-FABP significantly improved the discriminatory power of hs-cTnT and NT-proBNP. The composite cardiac score (AUC=0.866) further enhanced the predictive accuracy. Crude and adjusted Cox regressions models revealed that both sST2 and H-FABP were independently associated with in-hospital mortality (HR for sST2 ≥129 ng/mL, 4.32 [1.48-12.59]; HR for H-FABP ≥18 ng/mL, 7.70 [2.12-28.01]). The composite cardiac score also independently correlated with in-hospital mortality (HR for 1-unit increase, 1.47 [1.14-1.90]). In older patients with COVID-19, sST2 and H-FABP demonstrated prognostic value, improving the predictive accuracy of the routinely assessed biomarkers hs-cTnT and NT-proBNP | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Geriatric patients | |
| 650 | 4 | |a Heart-type fatty acid binding protein | |
| 650 | 4 | |a In-hospital mortality | |
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| 700 | 1 | |a Di Rosa, Mirko |e verfasserin |4 aut | |
| 700 | 1 | |a Giuliani, Angelica |e verfasserin |4 aut | |
| 700 | 1 | |a Domenichelli, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Bonfigli, Anna Rita |e verfasserin |4 aut | |
| 700 | 1 | |a Sarzani, Riccardo |e verfasserin |4 aut | |
| 700 | 1 | |a Cherubini, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Antonicelli, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Burattini, Maurizio |e verfasserin |4 aut | |
| 700 | 1 | |a Corsonello, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Galeazzi, Roberta |e verfasserin |4 aut | |
| 700 | 1 | |a Babini, Lucia |e verfasserin |4 aut | |
| 700 | 1 | |a Moretti, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Procopio, Antonio Domenico |e verfasserin |4 aut | |
| 700 | 1 | |a Lattanzio, Fabrizia |e verfasserin |4 aut | |
| 700 | 1 | |a Olivieri, Fabiola |e verfasserin |4 aut | |
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