Antigenic mapping of the hemagglutinin of the H9 subtype influenza A viruses using sera from Japanese quail (Coturnix c. japonica)
IMPORTANCE: Determining the relevant amino acids involved in antigenic drift on the surface protein hemagglutinin (HA) is critical to understand influenza virus evolution and efficient assessment of vaccine strains relative to current circulating strains. We used antigenic cartography to generate an antigenic map of the H9 hemagglutinin (HA) using sera produced in one of the most relevant minor poultry species, Japanese quail. Key antigenic positions were identified and tested to confirm their impact on the antigenic profile. This work provides a better understanding of the antigenic diversity of the H9 HA as it relates to reactivity to quail sera and will facilitate a rational approach for selecting more efficacious vaccines against poultry-origin H9 influenza viruses in minor poultry species.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:97 |
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| Enthalten in: |
Journal of virology - 97(2023), 10 vom: 31. Okt., Seite e0074323 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Carnaccini, Silvia [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 04.01.2024 Date Revised 12.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1128/jvi.00743-23 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM362945632 |
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| 100 | 1 | |a Carnaccini, Silvia |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Antigenic mapping of the hemagglutinin of the H9 subtype influenza A viruses using sera from Japanese quail (Coturnix c. japonica) |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Revised 12.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a IMPORTANCE: Determining the relevant amino acids involved in antigenic drift on the surface protein hemagglutinin (HA) is critical to understand influenza virus evolution and efficient assessment of vaccine strains relative to current circulating strains. We used antigenic cartography to generate an antigenic map of the H9 hemagglutinin (HA) using sera produced in one of the most relevant minor poultry species, Japanese quail. Key antigenic positions were identified and tested to confirm their impact on the antigenic profile. This work provides a better understanding of the antigenic diversity of the H9 HA as it relates to reactivity to quail sera and will facilitate a rational approach for selecting more efficacious vaccines against poultry-origin H9 influenza viruses in minor poultry species | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Asia | |
| 650 | 4 | |a H9N2 | |
| 650 | 4 | |a Japanese quail | |
| 650 | 4 | |a antigenic cartography | |
| 650 | 4 | |a influenza | |
| 650 | 4 | |a minor poultry | |
| 650 | 4 | |a poultry | |
| 650 | 4 | |a reverse genetics | |
| 650 | 4 | |a vaccine selection | |
| 650 | 4 | |a zoonotic infections | |
| 650 | 7 | |a Hemagglutinin Glycoproteins, Influenza Virus |2 NLM | |
| 700 | 1 | |a Cáceres, C Joaquín |e verfasserin |4 aut | |
| 700 | 1 | |a Gay, L Claire |e verfasserin |4 aut | |
| 700 | 1 | |a Ferreri, Lucas M |e verfasserin |4 aut | |
| 700 | 1 | |a Skepner, Eugene |e verfasserin |4 aut | |
| 700 | 1 | |a Burke, David F |e verfasserin |4 aut | |
| 700 | 1 | |a Brown, Ian H |e verfasserin |4 aut | |
| 700 | 1 | |a Geiger, Ginger |e verfasserin |4 aut | |
| 700 | 1 | |a Obadan, Adebimpe |e verfasserin |4 aut | |
| 700 | 1 | |a Rajao, Daniela S |e verfasserin |4 aut | |
| 700 | 1 | |a Lewis, Nicola S |e verfasserin |4 aut | |
| 700 | 1 | |a Perez, Daniel R |e verfasserin |4 aut | |
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