Hippocampal neurons code individual episodic memories in humans
© 2023. The Author(s)..
The hippocampus is an essential hub for episodic memory processing. However, how human hippocampal single neurons code multi-element associations remains unknown. In particular, it is debated whether each hippocampal neuron represents an invariant element within an episode or whether single neurons bind together all the elements of a discrete episodic memory. Here we provide evidence for the latter hypothesis. Using single-neuron recordings from a total of 30 participants, we show that individual neurons, which we term episode-specific neurons, code discrete episodic memories using either a rate code or a temporal firing code. These neurons were observed exclusively in the hippocampus. Importantly, these episode-specific neurons do not reflect the coding of a particular element in the episode (that is, concept or time). Instead, they code for the conjunction of the different elements that make up the episode.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
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| Enthalten in: |
Nature human behaviour - 7(2023), 11 vom: 05. Nov., Seite 1968-1979 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kolibius, Luca D [VerfasserIn] |
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| Anmerkungen: |
Date Completed 27.11.2023 Date Revised 10.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41562-023-01706-6 |
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| Förderinstitution / Projekttitel: |
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| 520 | |a © 2023. The Author(s). | ||
| 520 | |a The hippocampus is an essential hub for episodic memory processing. However, how human hippocampal single neurons code multi-element associations remains unknown. In particular, it is debated whether each hippocampal neuron represents an invariant element within an episode or whether single neurons bind together all the elements of a discrete episodic memory. Here we provide evidence for the latter hypothesis. Using single-neuron recordings from a total of 30 participants, we show that individual neurons, which we term episode-specific neurons, code discrete episodic memories using either a rate code or a temporal firing code. These neurons were observed exclusively in the hippocampus. Importantly, these episode-specific neurons do not reflect the coding of a particular element in the episode (that is, concept or time). Instead, they code for the conjunction of the different elements that make up the episode | ||
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| 700 | 1 | |a Van Der Plas, Mircea |e verfasserin |4 aut | |
| 700 | 1 | |a Chelvarajah, Ramesh |e verfasserin |4 aut | |
| 700 | 1 | |a Sawlani, Vijay |e verfasserin |4 aut | |
| 700 | 1 | |a Rollings, David T |e verfasserin |4 aut | |
| 700 | 1 | |a Lang, Johannes D |e verfasserin |4 aut | |
| 700 | 1 | |a Gollwitzer, Stephanie |e verfasserin |4 aut | |
| 700 | 1 | |a Walther, Katrin |e verfasserin |4 aut | |
| 700 | 1 | |a Hopfengärtner, Rüdiger |e verfasserin |4 aut | |
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| 700 | 1 | |a Staresina, Bernhard P |e verfasserin |4 aut | |
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| 700 | 1 | |a Hanslmayr, Simon |e verfasserin |4 aut | |
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