Protective and therapeutic potential of melatonin against intestinal diseases : updated review of current data based on molecular mechanisms
INTRODUCTION: Intestinal diseases, a leading global cause of mortality and morbidity, carry a substantial socioeconomic burden. Small and large intestines play pivotal roles in gastrointestinal physiology and food digestion. Pathological conditions, such as gut dysbiosis, inflammation, cancer, therapy-related complications, ulcers, and ischemia, necessitate the urgent exploration of safe and effective complementary therapeutic strategies for optimal intestinal health.
AREAS COVERED: This article evaluates the potential therapeutic effects of melatonin, a molecule with a wide range of physiological actions, on intestinal diseases including inflammatory bowel disease, irritable bowel syndrome, colon cancer, gastric/duodenal ulcers and other intestinal disorders.
EXPERT OPINION: Due to anti-inflammatory and antioxidant properties as well as various biological actions, melatonin could be a therapeutic option for improving digestive disorders. However, more researches are needed to fully understand the potential benefits and risks of using melatonin for digestive disorders.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
Expert review of gastroenterology & hepatology - 17(2023), 10 vom: 01. Juli, Seite 1011-1029 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mehrzadi, Saeed [VerfasserIn] |
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| Links: |
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| Themen: |
Antioxidants |
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| Anmerkungen: |
Date Completed 02.11.2023 Date Revised 02.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/17474124.2023.2267439 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM362904677 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a INTRODUCTION: Intestinal diseases, a leading global cause of mortality and morbidity, carry a substantial socioeconomic burden. Small and large intestines play pivotal roles in gastrointestinal physiology and food digestion. Pathological conditions, such as gut dysbiosis, inflammation, cancer, therapy-related complications, ulcers, and ischemia, necessitate the urgent exploration of safe and effective complementary therapeutic strategies for optimal intestinal health | ||
| 520 | |a AREAS COVERED: This article evaluates the potential therapeutic effects of melatonin, a molecule with a wide range of physiological actions, on intestinal diseases including inflammatory bowel disease, irritable bowel syndrome, colon cancer, gastric/duodenal ulcers and other intestinal disorders | ||
| 520 | |a EXPERT OPINION: Due to anti-inflammatory and antioxidant properties as well as various biological actions, melatonin could be a therapeutic option for improving digestive disorders. However, more researches are needed to fully understand the potential benefits and risks of using melatonin for digestive disorders | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Melatonin | |
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| 650 | 4 | |a irritable bowel syndrome | |
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| 700 | 1 | |a Koosha, Fereshteh |e verfasserin |4 aut | |
| 700 | 1 | |a Alinaghian, Nazila |e verfasserin |4 aut | |
| 700 | 1 | |a Pourhanifeh, Mohammad Hossein |e verfasserin |4 aut | |
| 700 | 1 | |a Tabaeian, Seid Amir Pasha |e verfasserin |4 aut | |
| 700 | 1 | |a Reiter, Russel J |e verfasserin |4 aut | |
| 700 | 1 | |a Hosseinzadeh, Azam |e verfasserin |4 aut | |
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