The effects of alpha-pinene on inflammatory responses and oxidative stress in the formalin test
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved..
Alpha-pinene (α- pinene), an essential oil that falls under the category of monoterpenes, has various advantages. This research delves into the potential benefits of α-pinene in alleviating nociception caused by the formalin test and the molecular mechanisms involved. Alpha-pinene (1, 5, or 10 mg/kg/day, i.p.) was administrated for 7 days before the formalin test. Observations of nociceptive behaviors were made during the formalin test. We examined the levels of TNF-α and IL-1β, as well as the expression of COX-1 in the spinal cord. Additionally, we evaluated the levels of TNF-α, IL-1β, SOD, GSH, CAT, and MDA in the skin of the hind paw that received a formalin injection. The peripheral injection of formalin triggered nociceptive behaviors, which was notably diminished by α-pinene 5 or 10 mg/kg. The biochemical evaluation revealed that α-pinene significantly moderated the evaluation in TNF-α and IL-1β in the spinal cord induced by formalin injection. Additionally, it was found that α-pinene had a decreasing effect on the expression of COX-1 protein in the spinal cord. Also, α-pinene 5 or 10 mg/kg caused a decrease of TNF-α, IL-1β, and MDA and an increase of SOD, GSH, and CAT at the formalin injection site. The study discovered that doses of 5 or 10 mg/ml of α-pinene can effectively relieve nociceptive response in the formalin test. Alpha-pinene pretreatment reduced the presence of pro-inflammatory cytokines. It also improved the oxidative stress condition by enhancing antioxidant factors and reducing oxidant factors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:203 |
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| Enthalten in: |
Brain research bulletin - 203(2023) vom: 15. Okt., Seite 110774 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rahimi, Kaveh [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 23.10.2023 Date Revised 06.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.brainresbull.2023.110774 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Alpha-pinene (α- pinene), an essential oil that falls under the category of monoterpenes, has various advantages. This research delves into the potential benefits of α-pinene in alleviating nociception caused by the formalin test and the molecular mechanisms involved. Alpha-pinene (1, 5, or 10 mg/kg/day, i.p.) was administrated for 7 days before the formalin test. Observations of nociceptive behaviors were made during the formalin test. We examined the levels of TNF-α and IL-1β, as well as the expression of COX-1 in the spinal cord. Additionally, we evaluated the levels of TNF-α, IL-1β, SOD, GSH, CAT, and MDA in the skin of the hind paw that received a formalin injection. The peripheral injection of formalin triggered nociceptive behaviors, which was notably diminished by α-pinene 5 or 10 mg/kg. The biochemical evaluation revealed that α-pinene significantly moderated the evaluation in TNF-α and IL-1β in the spinal cord induced by formalin injection. Additionally, it was found that α-pinene had a decreasing effect on the expression of COX-1 protein in the spinal cord. Also, α-pinene 5 or 10 mg/kg caused a decrease of TNF-α, IL-1β, and MDA and an increase of SOD, GSH, and CAT at the formalin injection site. The study discovered that doses of 5 or 10 mg/ml of α-pinene can effectively relieve nociceptive response in the formalin test. Alpha-pinene pretreatment reduced the presence of pro-inflammatory cytokines. It also improved the oxidative stress condition by enhancing antioxidant factors and reducing oxidant factors | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Salari, Ghazal |e verfasserin |4 aut | |
| 700 | 1 | |a Baghdezfoli, Fatemeh |e verfasserin |4 aut | |
| 700 | 1 | |a Ebrahimifar, Akram |e verfasserin |4 aut | |
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