Are enterococcal bloodstream infections an independent risk factor for a poorer 5-year survival or just a marker for severity of illness?-The Munich multicentric enterococci cohort
IMPORTANCE: The present study provides a substantial contribution to literature, showing that patients with enterococcal bloodstream infections (BSI) have a lower survival rate than those with Escherichia coli (E. coli) bloodstream infections after adjusting for 17 limiting prognostic factors and excluding patients with a limited life expectancy [metastatic tumor disease, Charlson Comorbidity Index (CCI) (greater than or equal to) 5]. This difference in the 5-year long-term survival was mainly driven by Enterococcus faecium (ECFM) bloodstream infections, with vancomycin resistance not being a significant contributing factor. Our findings imply that E. faecium bloodstream infections seem to be an independent risk factor for poor long-term outcomes. As such, future research should confirm this relationship and prioritize investigating its causality through prospective studies.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
|---|---|
| Enthalten in: |
Microbiology spectrum - 11(2023), 6 vom: 12. Dez., Seite e0258523 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rothe, Kathrin [VerfasserIn] |
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| Links: |
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| Themen: |
5-year survival |
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| Anmerkungen: |
Date Completed 16.12.2023 Date Revised 16.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1128/spectrum.02585-23 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM362855250 |
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| 245 | 1 | 0 | |a Are enterococcal bloodstream infections an independent risk factor for a poorer 5-year survival or just a marker for severity of illness?-The Munich multicentric enterococci cohort |
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| 520 | |a IMPORTANCE: The present study provides a substantial contribution to literature, showing that patients with enterococcal bloodstream infections (BSI) have a lower survival rate than those with Escherichia coli (E. coli) bloodstream infections after adjusting for 17 limiting prognostic factors and excluding patients with a limited life expectancy [metastatic tumor disease, Charlson Comorbidity Index (CCI) (greater than or equal to) 5]. This difference in the 5-year long-term survival was mainly driven by Enterococcus faecium (ECFM) bloodstream infections, with vancomycin resistance not being a significant contributing factor. Our findings imply that E. faecium bloodstream infections seem to be an independent risk factor for poor long-term outcomes. As such, future research should confirm this relationship and prioritize investigating its causality through prospective studies | ||
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| 700 | 1 | |a Karapetyan, Siranush |e verfasserin |4 aut | |
| 700 | 1 | |a Hapfelmeier, Alexander |e verfasserin |4 aut | |
| 700 | 1 | |a Wurst, Milena |e verfasserin |4 aut | |
| 700 | 1 | |a Gleich, Sabine |e verfasserin |4 aut | |
| 700 | 1 | |a Dichtl, Karl |e verfasserin |4 aut | |
| 700 | 1 | |a Schmid, Roland M |e verfasserin |4 aut | |
| 700 | 1 | |a Triebelhorn, Julian |e verfasserin |4 aut | |
| 700 | 1 | |a Wagner, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Erber, Johanna |e verfasserin |4 aut | |
| 700 | 1 | |a Voit, Florian |e verfasserin |4 aut | |
| 700 | 1 | |a Burgkart, Rainer |e verfasserin |4 aut | |
| 700 | 1 | |a Obermeier, Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a Seibold, Ulrich |e verfasserin |4 aut | |
| 700 | 1 | |a Busch, Dirk H |e verfasserin |4 aut | |
| 700 | 1 | |a Rämer, Patrick C |e verfasserin |4 aut | |
| 700 | 1 | |a Spinner, Christoph D |e verfasserin |4 aut | |
| 700 | 1 | |a Schneider, Jochen |e verfasserin |4 aut | |
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