Formal (4+2) cycloaddition of azoalkenes with trifluoromethylimidoyl sulfoxonium ylides : synthesis of trifluoromethyl pyridazine derivatives
CF3-substituted imidoyl sulfoxonium ylides (TFISYs) are extraordinarily versatile and powerful synthons for use in cyclization chemistry that affords diverse CF3-substituted N-heterocycles. We first reacted TFISYs as a two-atom synthon with readily available azoalkenes and then subjected the products to metal-free formal (4+2) cycloaddition chemistry. This protocol features mild conditions and broad substrate scope, is simple to operate, and provides highly functionalized trifluoromethylpyridazines that are widely found in bioactive molecules.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:59 |
|---|---|
| Enthalten in: |
Chemical communications (Cambridge, England) - 59(2023), 83 vom: 17. Okt., Seite 12495-12498 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Wang, Jie [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Revised 20.10.2023 published: Electronic Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.1039/d3cc03950a |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM362801878 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM362801878 | ||
| 003 | DE-627 | ||
| 005 | 20231226092011.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1039/d3cc03950a |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1209.xml |
| 035 | |a (DE-627)NLM362801878 | ||
| 035 | |a (NLM)37786379 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Wang, Jie |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Formal (4+2) cycloaddition of azoalkenes with trifluoromethylimidoyl sulfoxonium ylides |b synthesis of trifluoromethyl pyridazine derivatives |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 20.10.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a CF3-substituted imidoyl sulfoxonium ylides (TFISYs) are extraordinarily versatile and powerful synthons for use in cyclization chemistry that affords diverse CF3-substituted N-heterocycles. We first reacted TFISYs as a two-atom synthon with readily available azoalkenes and then subjected the products to metal-free formal (4+2) cycloaddition chemistry. This protocol features mild conditions and broad substrate scope, is simple to operate, and provides highly functionalized trifluoromethylpyridazines that are widely found in bioactive molecules | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Wang, Shan-Shan |e verfasserin |4 aut | |
| 700 | 1 | |a Xiao, Jun |e verfasserin |4 aut | |
| 700 | 1 | |a He, Yu-Jie |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Xin-Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xingguang |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Pei-Nian |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Chemical communications (Cambridge, England) |d 1998 |g 59(2023), 83 vom: 17. Okt., Seite 12495-12498 |w (DE-627)NLM095512322 |x 1364-548X |7 nnns |
| 773 | 1 | 8 | |g volume:59 |g year:2023 |g number:83 |g day:17 |g month:10 |g pages:12495-12498 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1039/d3cc03950a |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 59 |j 2023 |e 83 |b 17 |c 10 |h 12495-12498 | ||