The role of budesonide intrapolyp injection in the management of type 2 chronic rhinosinusitis with nasal polyps : a randomised clinical trial
PROBLEM: To assess the efficacy of budesonide intrapolyp injection in chronic rhinosinusitis with nasal polyps.
METHOD: Ninety patients were divided into three groups; group A was given oral prednisolone, group B was given budesonide intrapolyp injection weekly for five consecutive weeks and group C was given budesonide as nasal irrigation for one month. Patients were assessed using Sino-Nasal Outcome Test 22 score, total nasal polyp score, serum immunoglobulin E, absolute eosinophilic count, and morning cortisol level before treatment, one week and three months after completing their treatment.
RESULTS: Total nasal polyp score decreased significantly in all groups compared to those at baseline. Reduction in the oral and injection groups was greater than the wash group (p2 = 0.004), (p3 < 0.001), and the same trend concerning Sino-Nasal Outcome Test 22 score (p2 < 0.001), (p3 < 0.001).
CONCLUSION: Budesonide is an effective agent used in intrapolyp injection with no documented systemic or visual side effects that has comparable results with oral steroids.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:138 |
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| Enthalten in: |
The Journal of laryngology and otology - 138(2024), 4 vom: 02. März, Seite 416-424 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Elzayat, Saad [VerfasserIn] |
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| Links: |
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| Themen: |
51333-22-3 |
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| Anmerkungen: |
Date Completed 20.03.2024 Date Revised 20.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1017/S0022215123001688 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM362776148 |
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| 100 | 1 | |a Elzayat, Saad |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The role of budesonide intrapolyp injection in the management of type 2 chronic rhinosinusitis with nasal polyps |b a randomised clinical trial |
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| 500 | |a Date Completed 20.03.2024 | ||
| 500 | |a Date Revised 20.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a PROBLEM: To assess the efficacy of budesonide intrapolyp injection in chronic rhinosinusitis with nasal polyps | ||
| 520 | |a METHOD: Ninety patients were divided into three groups; group A was given oral prednisolone, group B was given budesonide intrapolyp injection weekly for five consecutive weeks and group C was given budesonide as nasal irrigation for one month. Patients were assessed using Sino-Nasal Outcome Test 22 score, total nasal polyp score, serum immunoglobulin E, absolute eosinophilic count, and morning cortisol level before treatment, one week and three months after completing their treatment | ||
| 520 | |a RESULTS: Total nasal polyp score decreased significantly in all groups compared to those at baseline. Reduction in the oral and injection groups was greater than the wash group (p2 = 0.004), (p3 < 0.001), and the same trend concerning Sino-Nasal Outcome Test 22 score (p2 < 0.001), (p3 < 0.001) | ||
| 520 | |a CONCLUSION: Budesonide is an effective agent used in intrapolyp injection with no documented systemic or visual side effects that has comparable results with oral steroids | ||
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Nasal obstruction | |
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| 650 | 4 | |a corticosteroids | |
| 650 | 4 | |a nasal polyps | |
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| 700 | 1 | |a Elgendy, Ahmed |e verfasserin |4 aut | |
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| 700 | 1 | |a Aouf, Mohammad Mahmoud |e verfasserin |4 aut | |
| 700 | 1 | |a Gehad, Ibrahim |e verfasserin |4 aut | |
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