Treatment of metastatic squamous cell carcinoma arising in sacrococcygeal pilonidal sinus : a case report series
Copyright © 2023 Soria Rivas, Bea-Ardebol, Vida Navas, Muñoz-Arrones, Cabañas-Montero, Mena-Mateos, López-Campos, Corral Moreno, Pérez-Muñoz, González Lizan, Sanz Pascual and Serrano Domingo..
Background: Squamous cell carcinoma (SCC) arising in a sacrococcygeal pilonidal sinus is rare, with cases of metastatic disease being even rarer. Among published cases, almost none have reported on systemic treatment.
Objective: This disease has a poorer prognosis than other forms of cutaneous SCC; therefore, our objective is to shed some light on the treatment of metastatic disease.
Methods: We present a series of nine cases treated at a single center, four of whom received systemic treatment. Additionally, other previously reported cases of metastatic disease are included in an attempt to draw stronger conclusions.
Results: Four patients were treated under several treatment regimens, with a median progression-free survival of only 2 months and two instances of partial response (18%). The best result was achieved with cemiplimab. Across all the cases, there was a trend toward a benefit of the use of systemic treatment (HR 0.41, 95% CI 0.15-1.12, p = 0.083; median overall survival 13 vs. 8 months).
Limitations: Limitations include the significant lack of information on previously published cases and the extremely heterogeneous nature of the existing information.
Conclusion: The initial systemic treatment should be an anti-PD-1, as with other SCCs. After progression on anti-PD-1, there is no strong evidence to support the recommendation of a specific treatment or sequence: options include cetuximab and/or chemotherapy (platinum, paclitaxel, 5-fluorouracyl).
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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Enthalten in: |
Frontiers in medicine - 10(2023) vom: 27., Seite 1248894 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Soria Rivas, Ainara [VerfasserIn] |
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Links: |
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Themen: |
Anti-PD-1 |
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Anmerkungen: |
Date Revised 03.10.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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doi: |
10.3389/fmed.2023.1248894 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM362764190 |
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520 | |a Background: Squamous cell carcinoma (SCC) arising in a sacrococcygeal pilonidal sinus is rare, with cases of metastatic disease being even rarer. Among published cases, almost none have reported on systemic treatment | ||
520 | |a Objective: This disease has a poorer prognosis than other forms of cutaneous SCC; therefore, our objective is to shed some light on the treatment of metastatic disease | ||
520 | |a Methods: We present a series of nine cases treated at a single center, four of whom received systemic treatment. Additionally, other previously reported cases of metastatic disease are included in an attempt to draw stronger conclusions | ||
520 | |a Results: Four patients were treated under several treatment regimens, with a median progression-free survival of only 2 months and two instances of partial response (18%). The best result was achieved with cemiplimab. Across all the cases, there was a trend toward a benefit of the use of systemic treatment (HR 0.41, 95% CI 0.15-1.12, p = 0.083; median overall survival 13 vs. 8 months) | ||
520 | |a Limitations: Limitations include the significant lack of information on previously published cases and the extremely heterogeneous nature of the existing information | ||
520 | |a Conclusion: The initial systemic treatment should be an anti-PD-1, as with other SCCs. After progression on anti-PD-1, there is no strong evidence to support the recommendation of a specific treatment or sequence: options include cetuximab and/or chemotherapy (platinum, paclitaxel, 5-fluorouracyl) | ||
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700 | 1 | |a Serrano Domingo, Juan Jose |e verfasserin |4 aut | |
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