Saliva contact during infancy and allergy development in school-age children
© 2023 The Author(s)..
Background: Parent-child saliva contact during infancy might stimulate the child's immune system for effective allergy prevention. However, few studies have investigated its relation to allergy development in school-age children.
Objective: We sought to investigate the relationship between parent-child saliva contact during infancy and allergy development at school age.
Methods: We performed a large multicenter cross-sectional study involving Japanese school children and their parents. The self-administered questionnaires including questions from the International Study of Asthma and Allergies in Childhood were distributed to 3570 elementary and junior high school children in 2 local cities. Data were analyzed for the relationship between saliva contact during infancy (age <12 months) and the risk of allergy development, specifically eczema, allergic rhinitis, and asthma. For detailed Methods, please see the Methods section in this article's Online Repository at www.jacionline.org.
Results: The valid response rate was 94.7%. The mean and median age of children was 10.8 ± 2.7 and 11 (interquartile range, 9-13) years, respectively. Saliva contact via sharing eating utensils during infancy was significantly associated with a lower risk of eczema (odds ratio, 0.53; 95% CI, 0.34-0.83) at school age. Saliva contact via parental sucking of pacifiers was significantly associated with a lower risk of eczema (odds ratio, 0.24; 95% CI, 0.10-0.60) and allergic rhinitis (odds ratio, 0.33; 95% CI, 0.15-0.73), and had a borderline association with the risk of asthma in school-age children.
Conclusions: Saliva contact during infancy may reduce the risk of developing eczema and allergic rhinitis in school-age children.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2 |
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| Enthalten in: |
The journal of allergy and clinical immunology. Global - 2(2023), 3 vom: 18. Aug., Seite 100108 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kubo, Yoshimi [VerfasserIn] |
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| Links: |
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| Themen: |
Allergic rhinitis |
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| Anmerkungen: |
Date Revised 30.10.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.jacig.2023.100108 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM362753768 |
|---|
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| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2023 The Author(s). | ||
| 520 | |a Background: Parent-child saliva contact during infancy might stimulate the child's immune system for effective allergy prevention. However, few studies have investigated its relation to allergy development in school-age children | ||
| 520 | |a Objective: We sought to investigate the relationship between parent-child saliva contact during infancy and allergy development at school age | ||
| 520 | |a Methods: We performed a large multicenter cross-sectional study involving Japanese school children and their parents. The self-administered questionnaires including questions from the International Study of Asthma and Allergies in Childhood were distributed to 3570 elementary and junior high school children in 2 local cities. Data were analyzed for the relationship between saliva contact during infancy (age <12 months) and the risk of allergy development, specifically eczema, allergic rhinitis, and asthma. For detailed Methods, please see the Methods section in this article's Online Repository at www.jacionline.org | ||
| 520 | |a Results: The valid response rate was 94.7%. The mean and median age of children was 10.8 ± 2.7 and 11 (interquartile range, 9-13) years, respectively. Saliva contact via sharing eating utensils during infancy was significantly associated with a lower risk of eczema (odds ratio, 0.53; 95% CI, 0.34-0.83) at school age. Saliva contact via parental sucking of pacifiers was significantly associated with a lower risk of eczema (odds ratio, 0.24; 95% CI, 0.10-0.60) and allergic rhinitis (odds ratio, 0.33; 95% CI, 0.15-0.73), and had a borderline association with the risk of asthma in school-age children | ||
| 520 | |a Conclusions: Saliva contact during infancy may reduce the risk of developing eczema and allergic rhinitis in school-age children | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Allergy | |
| 650 | 4 | |a allergic rhinitis | |
| 650 | 4 | |a eating utensils | |
| 650 | 4 | |a eczema | |
| 650 | 4 | |a infancy | |
| 650 | 4 | |a oral microbes | |
| 650 | 4 | |a pacifier | |
| 650 | 4 | |a saliva contact | |
| 650 | 4 | |a school age | |
| 700 | 1 | |a Kanazawa, Nobuo |e verfasserin |4 aut | |
| 700 | 1 | |a Fukuda, Hironobu |e verfasserin |4 aut | |
| 700 | 1 | |a Inaba, Yutaka |e verfasserin |4 aut | |
| 700 | 1 | |a Mikita, Naoya |e verfasserin |4 aut | |
| 700 | 1 | |a Jinnin, Masatoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Furukawa, Fukumi |e verfasserin |4 aut | |
| 700 | 1 | |a Kuraishi, Yasushi |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshihara, Shigemi |e verfasserin |4 aut | |
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