Brain positron emission tomography in idiopathic normal-pressure hydrocephalus : new 18 F-fluorodeoxyglucose pattern in a long-known syndrome
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved..
AIM: Patients with idiopathic normal-pressure hydrocephalus (iNPH) can show a global reduction in cerebral glucose metabolism at [ 18 F]Fluorodeoxyglucose (FDG) PET. The presence of caudate hypometabolism has been identified as a potential biomarker in iNPH, yet there is limited evidence of hypermetabolic findings in patients with iNPH so far.
METHODS: We retrieved retrospectively patients with iNPH and normal cognitive assessment, evaluated before surgery undergoing brain [ 18 F]FDG-PET. The 18 F-FDG-PET brain scans were compared to those of a control group of healthy subjects, matched for age and sex, by statistical parametric mapping (SPM) to identify areas of relative hypo- and hypermetabolism. Furthermore, the existence of a correlation between areas of hypo- and hypermetabolism in the patient group was tested.
RESULTS: Seven iNPH patients (mean age 74 ± 6 years) were found in the hospital database. SPM group analysis revealed clusters of significant hypometabolism ( P = 0.001) in the iNPH group in the dorsal striatum, involving caudate and putamen bilaterally. Clusters of significant hypermetabolism ( P = 0.001) were revealed in the bilateral superior and precentral frontal gyrus (BA 4, 6). A significant inverse correlation between striatal hypometabolism and bilateral superior and precentral frontal gyrus hypermetabolism was revealed ( P < 0.001 corrected for multiple comparisons).
CONCLUSION: In this cohort, patients with iNPH showed subcortical hypometabolism, including bilateral dorsal striatum. To the best of our knowledge, this is the first report demonstrating a hypermetabolic pattern in the primary motor and premotor areas, and showing an inverse correlation between the striatum and motor cortex in patients with iNPH.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:44 |
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| Enthalten in: |
Nuclear medicine communications - 44(2023), 12 vom: 01. Dez., Seite 1163-1167 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cistaro, Angelina [VerfasserIn] |
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| Anmerkungen: |
Date Completed 09.11.2023 Date Revised 09.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1097/MNM.0000000000001763 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM362752907 |
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| 100 | 1 | |a Cistaro, Angelina |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Brain positron emission tomography in idiopathic normal-pressure hydrocephalus |b new 18 F-fluorodeoxyglucose pattern in a long-known syndrome |
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| 500 | |a Date Revised 09.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. | ||
| 520 | |a AIM: Patients with idiopathic normal-pressure hydrocephalus (iNPH) can show a global reduction in cerebral glucose metabolism at [ 18 F]Fluorodeoxyglucose (FDG) PET. The presence of caudate hypometabolism has been identified as a potential biomarker in iNPH, yet there is limited evidence of hypermetabolic findings in patients with iNPH so far | ||
| 520 | |a METHODS: We retrieved retrospectively patients with iNPH and normal cognitive assessment, evaluated before surgery undergoing brain [ 18 F]FDG-PET. The 18 F-FDG-PET brain scans were compared to those of a control group of healthy subjects, matched for age and sex, by statistical parametric mapping (SPM) to identify areas of relative hypo- and hypermetabolism. Furthermore, the existence of a correlation between areas of hypo- and hypermetabolism in the patient group was tested | ||
| 520 | |a RESULTS: Seven iNPH patients (mean age 74 ± 6 years) were found in the hospital database. SPM group analysis revealed clusters of significant hypometabolism ( P = 0.001) in the iNPH group in the dorsal striatum, involving caudate and putamen bilaterally. Clusters of significant hypermetabolism ( P = 0.001) were revealed in the bilateral superior and precentral frontal gyrus (BA 4, 6). A significant inverse correlation between striatal hypometabolism and bilateral superior and precentral frontal gyrus hypermetabolism was revealed ( P < 0.001 corrected for multiple comparisons) | ||
| 520 | |a CONCLUSION: In this cohort, patients with iNPH showed subcortical hypometabolism, including bilateral dorsal striatum. To the best of our knowledge, this is the first report demonstrating a hypermetabolic pattern in the primary motor and premotor areas, and showing an inverse correlation between the striatum and motor cortex in patients with iNPH | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Fluorodeoxyglucose F18 |2 NLM | |
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| 700 | 1 | |a Quartuccio, Natale |e verfasserin |4 aut | |
| 700 | 1 | |a Piccardo, Arnoldo |e verfasserin |4 aut | |
| 700 | 1 | |a Meo, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Gandoglia, Ilaria |e verfasserin |4 aut | |
| 700 | 1 | |a Schiera, Irene Giovanna |e verfasserin |4 aut | |
| 700 | 1 | |a Fania, Piercarlo |e verfasserin |4 aut | |
| 700 | 1 | |a Lupidi, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Bottoni, Gianluca |e verfasserin |4 aut | |
| 700 | 1 | |a Massollo, Michela |e verfasserin |4 aut | |
| 700 | 1 | |a Altrinetti, Vania |e verfasserin |4 aut | |
| 700 | 1 | |a Pestarino, Emanuela |e verfasserin |4 aut | |
| 700 | 1 | |a Iacozzi, Massimiliano |e verfasserin |4 aut | |
| 700 | 1 | |a Iantorno, Massimiliano |e verfasserin |4 aut | |
| 700 | 1 | |a Del Sette, Massimo |e verfasserin |4 aut | |
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