Distribution of dim light melatonin offset (DLMOff) and phase relationship to waketime in healthy adults and associations with chronotype
Copyright © 2024 National Sleep Foundation. All rights reserved..
OBJECTIVES: Dim light melatonin onset, or the rise in melatonin levels representing the beginning of the biological night, is the gold standard indicator of circadian phase. Considerably less is known about dim light melatonin offset, or the decrease in melatonin to low daytime levels representing the end of the biological night. In the context of insufficient sleep, morning circadian misalignment, or energy intake after waketime but before dim light melatonin offset, is linked to impaired insulin sensitivity, suggesting the need to characterize dim light melatonin offset and identify risk for morning circadian misalignment.
METHODS: We examined the distributions of dim light melatonin offset clock hour and the phase relationship between dim light melatonin offset and waketime, and associations between dim light melatonin offset, phase relationship, and chronotype in healthy adults (N = 62) who completed baseline protocols measuring components of the circadian melatonin rhythm and chronotype.
RESULTS: 74.4% demonstrated dim light melatonin offset after waketime, indicating most healthy adults wake up before the end of biological night. Later chronotype (morningness-eveningness, mid-sleep on free days corrected, and average mid-sleep) was associated with later dim light melatonin offset clock hour. Later chronotype was also associated with a larger, positive phase relationship between dim light melatonin offset and waketime, except for morningness-eveningness.
CONCLUSIONS: These findings suggest morning circadian misalignment risk among healthy adults, which would not be detected if only dim light melatonin onset were assessed. Chronotype measured by sleep timing may better predict this risk in healthy adults keeping a consistent sleep schedule than morningness-eveningness preferences. Additional research is needed to develop circadian biomarkers to predict dim light melatonin offset and evaluate appropriate dim light melatonin offset timing to promote health.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Sleep health - 10(2024), 1S vom: 20. Feb., Seite S76-S83 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cox, Rebecca C [VerfasserIn] |
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| Links: |
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| Themen: |
Chronotype |
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| Anmerkungen: |
Date Completed 22.04.2024 Date Revised 22.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.sleh.2023.08.017 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM362732809 |
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| 100 | 1 | |a Cox, Rebecca C |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Distribution of dim light melatonin offset (DLMOff) and phase relationship to waketime in healthy adults and associations with chronotype |
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| 500 | |a Date Completed 22.04.2024 | ||
| 500 | |a Date Revised 22.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 National Sleep Foundation. All rights reserved. | ||
| 520 | |a OBJECTIVES: Dim light melatonin onset, or the rise in melatonin levels representing the beginning of the biological night, is the gold standard indicator of circadian phase. Considerably less is known about dim light melatonin offset, or the decrease in melatonin to low daytime levels representing the end of the biological night. In the context of insufficient sleep, morning circadian misalignment, or energy intake after waketime but before dim light melatonin offset, is linked to impaired insulin sensitivity, suggesting the need to characterize dim light melatonin offset and identify risk for morning circadian misalignment | ||
| 520 | |a METHODS: We examined the distributions of dim light melatonin offset clock hour and the phase relationship between dim light melatonin offset and waketime, and associations between dim light melatonin offset, phase relationship, and chronotype in healthy adults (N = 62) who completed baseline protocols measuring components of the circadian melatonin rhythm and chronotype | ||
| 520 | |a RESULTS: 74.4% demonstrated dim light melatonin offset after waketime, indicating most healthy adults wake up before the end of biological night. Later chronotype (morningness-eveningness, mid-sleep on free days corrected, and average mid-sleep) was associated with later dim light melatonin offset clock hour. Later chronotype was also associated with a larger, positive phase relationship between dim light melatonin offset and waketime, except for morningness-eveningness | ||
| 520 | |a CONCLUSIONS: These findings suggest morning circadian misalignment risk among healthy adults, which would not be detected if only dim light melatonin onset were assessed. Chronotype measured by sleep timing may better predict this risk in healthy adults keeping a consistent sleep schedule than morningness-eveningness preferences. Additional research is needed to develop circadian biomarkers to predict dim light melatonin offset and evaluate appropriate dim light melatonin offset timing to promote health | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Chronotype | |
| 650 | 4 | |a Circadian misalignment | |
| 650 | 4 | |a Dim light melatonin offset | |
| 650 | 4 | |a Dim light melatonin onset | |
| 650 | 4 | |a Melatonin duration | |
| 650 | 4 | |a Phase angle of entrainment | |
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| 700 | 1 | |a Blumenstein, Alivia B |e verfasserin |4 aut | |
| 700 | 1 | |a Burke, Tina M |e verfasserin |4 aut | |
| 700 | 1 | |a Depner, Christopher M |e verfasserin |4 aut | |
| 700 | 1 | |a Guerin, Molly K |e verfasserin |4 aut | |
| 700 | 1 | |a Hay-Arthur, Emily |e verfasserin |4 aut | |
| 700 | 1 | |a Higgins, Janine |e verfasserin |4 aut | |
| 700 | 1 | |a Knauer, Oliver A |e verfasserin |4 aut | |
| 700 | 1 | |a Lanza, Shannon M |e verfasserin |4 aut | |
| 700 | 1 | |a Markwald, Rachel R |e verfasserin |4 aut | |
| 700 | 1 | |a Melanson, Edward L |e verfasserin |4 aut | |
| 700 | 1 | |a McHill, Andrew W |e verfasserin |4 aut | |
| 700 | 1 | |a Morton, Sarah J |e verfasserin |4 aut | |
| 700 | 1 | |a Ritchie, Hannah K |e verfasserin |4 aut | |
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| 700 | 1 | |a Wright, Kenneth P |c Jr |e verfasserin |4 aut | |
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