Acemannan ameliorates STZ-activated diabetes by attenuating high glucose via inhibiting inflammatory cytokines and apoptosis pathway
Copyright © 2023 Elsevier B.V. All rights reserved..
Acemannan, the main polysaccharide in Aloe vera, is a -(1, 4)-acetylated polymannose. According to numerous research findings, acemannan is a viable alternative for the treatment of pathological disorders. Streptozotocin (STZ, 60 mg/kg) administered intraperitoneally caused type 2 diabetes in rats. The current study sought to determine the anti-diabetic efficacy of acemannan (25 and 50 mg/kg) in STZ-injected rats. Different biochemical parameters including HbA1C, glucose and serum insulin, lipid profile, inflammatory markers, antioxidant, oxidative balance, liver function test, glycogen and creatinine, and caspase-3 were evaluated. In addition, a molecular docking study was performed to estimate acemannan's binding affinity to inflammatory markers. Acemannan may be a potent anti-diabetic agent for the treatment of diabetic patients, which will aid in future research into alternative diabetes medications.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:253 |
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| Enthalten in: |
International journal of biological macromolecules - 253(2023), Pt 5 vom: 31. Dez., Seite 127127 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Omer, Asma B [VerfasserIn] |
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| Links: |
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| Themen: |
5W494URQ81 |
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| Anmerkungen: |
Date Completed 27.11.2023 Date Revised 27.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijbiomac.2023.127127 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM362728518 |
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| 520 | |a Copyright © 2023 Elsevier B.V. All rights reserved. | ||
| 520 | |a Acemannan, the main polysaccharide in Aloe vera, is a -(1, 4)-acetylated polymannose. According to numerous research findings, acemannan is a viable alternative for the treatment of pathological disorders. Streptozotocin (STZ, 60 mg/kg) administered intraperitoneally caused type 2 diabetes in rats. The current study sought to determine the anti-diabetic efficacy of acemannan (25 and 50 mg/kg) in STZ-injected rats. Different biochemical parameters including HbA1C, glucose and serum insulin, lipid profile, inflammatory markers, antioxidant, oxidative balance, liver function test, glycogen and creatinine, and caspase-3 were evaluated. In addition, a molecular docking study was performed to estimate acemannan's binding affinity to inflammatory markers. Acemannan may be a potent anti-diabetic agent for the treatment of diabetic patients, which will aid in future research into alternative diabetes medications | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acemannan | |
| 650 | 4 | |a Apoptosis | |
| 650 | 4 | |a Docking study | |
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| 650 | 4 | |a Streptozotocin | |
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| 700 | 1 | |a Altayb, Hisham N |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Abbasi, Fahad A |e verfasserin |4 aut | |
| 700 | 1 | |a Gupta, Gaurav |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmed, Mohammed Muqtader |e verfasserin |4 aut | |
| 700 | 1 | |a Alghamdi, Amira M |e verfasserin |4 aut | |
| 700 | 1 | |a Alzarea, Sami I |e verfasserin |4 aut | |
| 700 | 1 | |a Sayyed, Nadeem |e verfasserin |4 aut | |
| 700 | 1 | |a Nadeem, Muhammad Shahid |e verfasserin |4 aut | |
| 700 | 1 | |a Kazmi, Imran |e verfasserin |4 aut | |
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