Establishment of an adverse effect prevention protocol on plasma exchange using fresh frozen plasma prior to ABO-incompatible living donor kidney transplantation at our hospital
© 2023 International Society for Apheresis and Japanese Society for Apheresis..
INTRODUCTION: Simple plasma exchange (PE) with fresh-frozen plasma replacement allows antibody removal for ABO-incompatible living donor kidney transplantation, but is associated with a high incidence of allergic reactions. We developed, implemented, and evaluated a protocol for safe preoperative PE.
METHODS: The protocol comprised pretreatment (125 mg methylprednisolone infusion, 400 mg acetaminophen and 30 mg diphenhydramine orally) with a replacement fluid rate < 20 mL/min. Allergic reaction incidence was investigated in controls who underwent ABO-incompatible living donor kidney transplantation between 2016 and March 2020 (group C) and patients who underwent the protocol and procedure between April 2020 and February 2023 (group N).
RESULTS: Ten (group C) and 19 (group N) patients performed 11 and 30 sessions of PE, respectively. Allergic reactions occurred in 81.8% and 36.7% (p = 0.014), respectively, with an odds ratio of the protocol was 0.056 (95% CI 0.0059-0.5380, P = 0.013).
CONCLUSION: Our protocol resulted in a significantly lower incidence of allergic reactions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
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| Enthalten in: |
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy - 28(2024), 1 vom: 01. Jan., Seite 152-157 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tanaka, Akihito [VerfasserIn] |
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| Links: |
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| Themen: |
ABO Blood-Group System |
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| Anmerkungen: |
Date Completed 04.01.2024 Date Revised 04.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/1744-9987.14071 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM362718490 |
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| 245 | 1 | 0 | |a Establishment of an adverse effect prevention protocol on plasma exchange using fresh frozen plasma prior to ABO-incompatible living donor kidney transplantation at our hospital |
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| 500 | |a Date Revised 04.01.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 International Society for Apheresis and Japanese Society for Apheresis. | ||
| 520 | |a INTRODUCTION: Simple plasma exchange (PE) with fresh-frozen plasma replacement allows antibody removal for ABO-incompatible living donor kidney transplantation, but is associated with a high incidence of allergic reactions. We developed, implemented, and evaluated a protocol for safe preoperative PE | ||
| 520 | |a METHODS: The protocol comprised pretreatment (125 mg methylprednisolone infusion, 400 mg acetaminophen and 30 mg diphenhydramine orally) with a replacement fluid rate < 20 mL/min. Allergic reaction incidence was investigated in controls who underwent ABO-incompatible living donor kidney transplantation between 2016 and March 2020 (group C) and patients who underwent the protocol and procedure between April 2020 and February 2023 (group N) | ||
| 520 | |a RESULTS: Ten (group C) and 19 (group N) patients performed 11 and 30 sessions of PE, respectively. Allergic reactions occurred in 81.8% and 36.7% (p = 0.014), respectively, with an odds ratio of the protocol was 0.056 (95% CI 0.0059-0.5380, P = 0.013) | ||
| 520 | |a CONCLUSION: Our protocol resulted in a significantly lower incidence of allergic reactions | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a ABO incompatible | |
| 650 | 4 | |a kidney transplantation | |
| 650 | 4 | |a plasma exchange | |
| 650 | 7 | |a ABO Blood-Group System |2 NLM | |
| 650 | 7 | |a Immunosuppressive Agents |2 NLM | |
| 700 | 1 | |a Watanabe, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Furuhashi, Kazuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Saito, Shoji |e verfasserin |4 aut | |
| 700 | 1 | |a Yasuda, Yoshinari |e verfasserin |4 aut | |
| 700 | 1 | |a Kosugi, Tomoki |e verfasserin |4 aut | |
| 700 | 1 | |a Sano, Yuta |e verfasserin |4 aut | |
| 700 | 1 | |a Kato, Masashi |e verfasserin |4 aut | |
| 700 | 1 | |a Maruyama, Shoichi |e verfasserin |4 aut | |
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