Stressful life events and depression and fatigue in people with multiple sclerosis : a cross-sectional analysis of an international cohort
© 2023. The Author(s)..
BACKGROUND: Relationships between stressful life events (SLEs) and health outcomes in people living with multiple sclerosis (plwMS), beyond relapse, are not well-established. We examined associations between SLEs and fatigue and symptoms of depression in plwMS.
METHODS: 948 participants were queried whether they had experienced any of the 16 SLEs (Holmes-Rahe Social Readjustment Rating Scale) in the preceding 12 months. SLEs were summated to estimate SLE number and SLE load (weighted for the degree of associated stress). Cross-sectional associations between SLE (number, load and individual) and fatigue, and depressive symptoms were examined using log-binomial or log-multinomial regression adjusted for age, sex, relapse symptoms, education, MS type at baseline, disability, fatigue, comorbidity, depression, and antidepressant/antifatigue medications, as appropriate. Sub-analyses restricted to SLEs with a negative emotional impact were performed.
RESULTS: Median SLE number and load were 2 (IQR 1-2) and 57 (IQR 28-97), respectively. SLE number and load were not associated with a higher prevalence of fatigue, or depressive symptoms, even when restricting analyses to SLEs with a perceived negative emotional impact. A new relationship or family member with a negative impact was associated with a threefold and 2.5-fold higher prevalence of depressive symptoms, respectively. Serious illness was associated with a 28% higher prevalence of depressive symptoms.
CONCLUSION: Psychological support for SLEs, and/or intervention targeted to SLE appraisal, may be beneficial in mitigating the adverse effects of SLEs with a perceived negative emotional impact on depressive symptoms in plwMS. Potential associations between serious illness and increased prevalence of depressive symptoms may warrant further investigation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:124 |
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| Enthalten in: |
Acta neurologica Belgica - 124(2024), 2 vom: 17. März, Seite 457-466 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Reece, Jeanette C [VerfasserIn] |
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| Links: |
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| Themen: |
Depressive symptoms |
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| Anmerkungen: |
Date Completed 27.03.2024 Date Revised 29.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s13760-023-02390-z |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM362670099 |
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| 100 | 1 | |a Reece, Jeanette C |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Stressful life events and depression and fatigue in people with multiple sclerosis |b a cross-sectional analysis of an international cohort |
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| 500 | |a Date Revised 29.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a BACKGROUND: Relationships between stressful life events (SLEs) and health outcomes in people living with multiple sclerosis (plwMS), beyond relapse, are not well-established. We examined associations between SLEs and fatigue and symptoms of depression in plwMS | ||
| 520 | |a METHODS: 948 participants were queried whether they had experienced any of the 16 SLEs (Holmes-Rahe Social Readjustment Rating Scale) in the preceding 12 months. SLEs were summated to estimate SLE number and SLE load (weighted for the degree of associated stress). Cross-sectional associations between SLE (number, load and individual) and fatigue, and depressive symptoms were examined using log-binomial or log-multinomial regression adjusted for age, sex, relapse symptoms, education, MS type at baseline, disability, fatigue, comorbidity, depression, and antidepressant/antifatigue medications, as appropriate. Sub-analyses restricted to SLEs with a negative emotional impact were performed | ||
| 520 | |a RESULTS: Median SLE number and load were 2 (IQR 1-2) and 57 (IQR 28-97), respectively. SLE number and load were not associated with a higher prevalence of fatigue, or depressive symptoms, even when restricting analyses to SLEs with a perceived negative emotional impact. A new relationship or family member with a negative impact was associated with a threefold and 2.5-fold higher prevalence of depressive symptoms, respectively. Serious illness was associated with a 28% higher prevalence of depressive symptoms | ||
| 520 | |a CONCLUSION: Psychological support for SLEs, and/or intervention targeted to SLE appraisal, may be beneficial in mitigating the adverse effects of SLEs with a perceived negative emotional impact on depressive symptoms in plwMS. Potential associations between serious illness and increased prevalence of depressive symptoms may warrant further investigation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Depressive symptoms | |
| 650 | 4 | |a Fatigue | |
| 650 | 4 | |a Multiple sclerosis | |
| 650 | 4 | |a Stressful life event | |
| 700 | 1 | |a Neate, Sandra L |e verfasserin |4 aut | |
| 700 | 1 | |a Davenport, Rebekah A |e verfasserin |4 aut | |
| 700 | 1 | |a Milanzi, Elasma |e verfasserin |4 aut | |
| 700 | 1 | |a Nag, Nupur |e verfasserin |4 aut | |
| 700 | 1 | |a Bevens, William |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Maggie |e verfasserin |4 aut | |
| 700 | 1 | |a Jelinek, George A |e verfasserin |4 aut | |
| 700 | 1 | |a Simpson-Yap, Steve |e verfasserin |4 aut | |
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