The association of upper respiratory infections with neuro-radiological course and attack rate of multiple sclerosis : Results from a large prospective cohort
© The Author(s), 2023..
Background: Although upper respiratory infections (URIs) are linked to multiple sclerosis (MS) attacks, SARS-COV2 has not been compared to URIs for attack rates.
Objectives: This study aimed to evaluate the attack rate and the results of neuroimaging in MS patients with URIs caused by COVID-19 and non-COVID-19 infections (NC-URI).
Methods: From May 2020 to April 2021, we followed 362 patients with relapsing-remitting MS in a prospective cohort design. Patients were monitored regularly every 12 weeks; an magnetic resonance imaging (MRI) scan was performed at enrollment and every time a relapse occurred. Poisson analysis was used to determine exacerbation rate ratios (RR) and the MRI parameters were tested using chi-square analysis.
Results: 347 patients with an average age of 38 and a female ratio of 86% were included. A RR of 2.24 (p < 0.001) was observed for exacerbations during the at-risk period (ARP). Attacks related to COVID-19 (RR = 2.13, p = 0.001) and NC-URIs (RR = 2.39, p < 0.001) were comparable regarding the increased risk of exacerbation (p = 0.62). Exacerbations within or outside the ARP did not significantly alter the number of baseline GAD-enhancing lesions (p > 0.05 for both).
Conclusion: COVID-19 has been shown to increase the risk of MS exacerbations, like other viral URIs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Multiple sclerosis journal - experimental, translational and clinical - 9(2023), 3 vom: 28. Juli, Seite 20552173231196992 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ghasemi, Moein [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Revised 03.10.2023 published: Electronic-eCollection Citation Status Publisher |
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| doi: |
10.1177/20552173231196992 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM362633754 |
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| 100 | 1 | |a Ghasemi, Moein |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The association of upper respiratory infections with neuro-radiological course and attack rate of multiple sclerosis |b Results from a large prospective cohort |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Revised 03.10.2023 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a © The Author(s), 2023. | ||
| 520 | |a Background: Although upper respiratory infections (URIs) are linked to multiple sclerosis (MS) attacks, SARS-COV2 has not been compared to URIs for attack rates | ||
| 520 | |a Objectives: This study aimed to evaluate the attack rate and the results of neuroimaging in MS patients with URIs caused by COVID-19 and non-COVID-19 infections (NC-URI) | ||
| 520 | |a Methods: From May 2020 to April 2021, we followed 362 patients with relapsing-remitting MS in a prospective cohort design. Patients were monitored regularly every 12 weeks; an magnetic resonance imaging (MRI) scan was performed at enrollment and every time a relapse occurred. Poisson analysis was used to determine exacerbation rate ratios (RR) and the MRI parameters were tested using chi-square analysis | ||
| 520 | |a Results: 347 patients with an average age of 38 and a female ratio of 86% were included. A RR of 2.24 (p < 0.001) was observed for exacerbations during the at-risk period (ARP). Attacks related to COVID-19 (RR = 2.13, p = 0.001) and NC-URIs (RR = 2.39, p < 0.001) were comparable regarding the increased risk of exacerbation (p = 0.62). Exacerbations within or outside the ARP did not significantly alter the number of baseline GAD-enhancing lesions (p > 0.05 for both) | ||
| 520 | |a Conclusion: COVID-19 has been shown to increase the risk of MS exacerbations, like other viral URIs | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a infection | |
| 650 | 4 | |a magnetic resonance imaging | |
| 650 | 4 | |a multiple sclerosis | |
| 650 | 4 | |a relapse | |
| 700 | 1 | |a Farazandeh, Dorreh |e verfasserin |4 aut | |
| 700 | 1 | |a Amini, Behnam |e verfasserin |4 aut | |
| 700 | 1 | |a Sedaghat, Mona |e verfasserin |4 aut | |
| 700 | 1 | |a Najafi, Anahita |e verfasserin |4 aut | |
| 700 | 1 | |a Khayatzadeh Kakhki, Simin |e verfasserin |4 aut | |
| 700 | 1 | |a Torabi, Pouya |e verfasserin |4 aut | |
| 700 | 1 | |a Jafarimehrabady, Niloofar |e verfasserin |4 aut | |
| 700 | 1 | |a Bitaraf, Ali |e verfasserin |4 aut | |
| 700 | 1 | |a Shariati, Houria |e verfasserin |4 aut | |
| 700 | 1 | |a Gholampour, Golsa |e verfasserin |4 aut | |
| 700 | 1 | |a Kazemi, Saminnaz |e verfasserin |4 aut | |
| 700 | 1 | |a Naser Moghadasi, Abdorreza |e verfasserin |4 aut | |
| 700 | 1 | |a Vajihinejad, Maryam |e verfasserin |4 aut | |
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