Epigenome-Wide Meta-analysis Reveals Associations Between Dietary Glycemic Index and Glycemic Load and DNA Methylation in Children and Adolescents of Different Body Sizes
© 2023 by the American Diabetes Association..
OBJECTIVE: Dietary glycemic index (GI) and glycemic load (GL) are associated with cardiometabolic health in children and adolescents, with potential distinct effects in people with increased BMI. DNA methylation (DNAm) may mediate these effects. Thus, we conducted meta-analyses of epigenome-wide association studies (EWAS) between dietary GI and GL and blood DNAm of children and adolescents.
RESEARCH DESIGN AND METHODS: We calculated dietary GI and GL and performed EWAS in children and adolescents (age range: 4.5-17 years) from six cohorts (N = 1,187). We performed stratified analyses of participants with normal weight (n = 801) or overweight or obesity (n = 386). We performed look-ups for the identified cytosine-phosphate-guanine (CpG) sites (false discovery rate [FDR] <0.05) with tissue-specific gene expression of 832 blood and 223 subcutaneous adipose tissue samples from children and adolescents.
RESULTS: Dietary GL was positively associated with DNAm of cg20274553 (FDR <0.05), annotated to WDR27. Several CpGs were identified in the normal-weight (GI: 85; GL: 17) and overweight or obese (GI: 136; GL: 298; FDR <0.05) strata, and none overlapped between strata. In participants with overweight or obesity, identified CpGs were related to RNA expression of genes associated with impaired metabolism (e.g., FRAT1, CSF3).
CONCLUSIONS: We identified 537 associations between dietary GI and GL and blood DNAm, mainly in children and adolescents with overweight or obesity. High-GI and/or -GL diets may influence epigenetic gene regulation and thereby promote metabolic derangements in young people with increased BMI.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
|---|---|
| Enthalten in: |
Diabetes care - 46(2023), 11 vom: 01. Nov., Seite 2067-2075 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Ott, Raffael [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Adaptor Proteins, Signal Transducing |
|---|
| Anmerkungen: |
Date Completed 30.10.2023 Date Revised 14.02.2024 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.2337/dc23-0474 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM362528373 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM362528373 | ||
| 003 | DE-627 | ||
| 005 | 20240214232821.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2337/dc23-0474 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1292.xml |
| 035 | |a (DE-627)NLM362528373 | ||
| 035 | |a (NLM)37756535 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Ott, Raffael |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Epigenome-Wide Meta-analysis Reveals Associations Between Dietary Glycemic Index and Glycemic Load and DNA Methylation in Children and Adolescents of Different Body Sizes |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 30.10.2023 | ||
| 500 | |a Date Revised 14.02.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 by the American Diabetes Association. | ||
| 520 | |a OBJECTIVE: Dietary glycemic index (GI) and glycemic load (GL) are associated with cardiometabolic health in children and adolescents, with potential distinct effects in people with increased BMI. DNA methylation (DNAm) may mediate these effects. Thus, we conducted meta-analyses of epigenome-wide association studies (EWAS) between dietary GI and GL and blood DNAm of children and adolescents | ||
| 520 | |a RESEARCH DESIGN AND METHODS: We calculated dietary GI and GL and performed EWAS in children and adolescents (age range: 4.5-17 years) from six cohorts (N = 1,187). We performed stratified analyses of participants with normal weight (n = 801) or overweight or obesity (n = 386). We performed look-ups for the identified cytosine-phosphate-guanine (CpG) sites (false discovery rate [FDR] <0.05) with tissue-specific gene expression of 832 blood and 223 subcutaneous adipose tissue samples from children and adolescents | ||
| 520 | |a RESULTS: Dietary GL was positively associated with DNAm of cg20274553 (FDR <0.05), annotated to WDR27. Several CpGs were identified in the normal-weight (GI: 85; GL: 17) and overweight or obese (GI: 136; GL: 298; FDR <0.05) strata, and none overlapped between strata. In participants with overweight or obesity, identified CpGs were related to RNA expression of genes associated with impaired metabolism (e.g., FRAT1, CSF3) | ||
| 520 | |a CONCLUSIONS: We identified 537 associations between dietary GI and GL and blood DNAm, mainly in children and adolescents with overweight or obesity. High-GI and/or -GL diets may influence epigenetic gene regulation and thereby promote metabolic derangements in young people with increased BMI | ||
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a FRAT1 protein, human |2 NLM | |
| 650 | 7 | |a Proto-Oncogene Proteins |2 NLM | |
| 650 | 7 | |a Adaptor Proteins, Signal Transducing |2 NLM | |
| 700 | 1 | |a Stein, Robert |e verfasserin |4 aut | |
| 700 | 1 | |a Hauta-Alus, Helena H |e verfasserin |4 aut | |
| 700 | 1 | |a Ronkainen, Justiina |e verfasserin |4 aut | |
| 700 | 1 | |a Fernández-Barrés, Sílvia |e verfasserin |4 aut | |
| 700 | 1 | |a Spielau, Ulrike |e verfasserin |4 aut | |
| 700 | 1 | |a Kirsten, Holger |e verfasserin |4 aut | |
| 700 | 1 | |a Poulain, Tanja |e verfasserin |4 aut | |
| 700 | 1 | |a Melton, Phillip E |e verfasserin |4 aut | |
| 700 | 1 | |a Küpers, Leanne K |e verfasserin |4 aut | |
| 700 | 1 | |a Azaryah, Hatim |e verfasserin |4 aut | |
| 700 | 1 | |a Colombo, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Landgraf, Kathrin |e verfasserin |4 aut | |
| 700 | 1 | |a Tobi, Elmar W |e verfasserin |4 aut | |
| 700 | 1 | |a O'Sullivan, Therese |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Rae-Chi |e verfasserin |4 aut | |
| 700 | 1 | |a Campoy, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Winkler, Christiane |e verfasserin |4 aut | |
| 700 | 1 | |a Vioque, Jesus |e verfasserin |4 aut | |
| 700 | 1 | |a Vrijheid, Martine |e verfasserin |4 aut | |
| 700 | 1 | |a Kiess, Wieland |e verfasserin |4 aut | |
| 700 | 1 | |a Körner, Antje |e verfasserin |4 aut | |
| 700 | 1 | |a Sebert, Sylvain |e verfasserin |4 aut | |
| 700 | 1 | |a Jarvelin, Marjo-Riitta |e verfasserin |4 aut | |
| 700 | 1 | |a Ziegler, Anette-G |e verfasserin |4 aut | |
| 700 | 1 | |a Hummel, Sandra |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Diabetes care |d 1979 |g 46(2023), 11 vom: 01. Nov., Seite 2067-2075 |w (DE-627)NLM00042983X |x 1935-5548 |7 nnns |
| 773 | 1 | 8 | |g volume:46 |g year:2023 |g number:11 |g day:01 |g month:11 |g pages:2067-2075 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.2337/dc23-0474 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 46 |j 2023 |e 11 |b 01 |c 11 |h 2067-2075 | ||