Change in Health-Related Quality of Life in Youth with Chronic Hepatitis B Living in North America : A 5-Year Cohort Study
Copyright © 2023 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition..
BACKGROUND: Greater hepatitis-related symptomology is associated with lower health-related quality-of-life (HRQoL) among untreated youth with chronic hepatitis B (CHB). How HRQoL changes over time in this population is unknown.
METHODS: Children from 7 hepatology centers in North America positive for hepatitis B surface antigen, not taking anti-viral therapy, were enrolled in the Hepatitis B Research Network. A validated self-report HRQoL measure, the Child Health Questionnaire Child Report (CHQ-CF87), was completed annually by participants 10-17 years, with demographic variables, liver disease symptoms, and laboratory tests. Linear mixed-effects models were used to evaluate the 10 CHQ-CF87 subscale scores over 5 years among participants who completed the CHQ-CF87 at least twice.
RESULTS: Participants (N = 174) completed the CHQ-CF87 a median of 4 times. Median age was 12 years (interquartile range: 10-14) at baseline; 60% were female, 79% Asian, and 47% adopted. The CHQ-CF87 subscale scores were high at baseline (median range: 75.4-100) and did not differ by time point, except for the Family Activities subscale (mean [95% CI]: 82.3 [79.8-84.8] at baseline; 90.8 [86.1-94.6] week 240). Most subscale scores lacked sufficient individual-level variability in change over time to evaluate predictors. Being White versus Asian predicted a more favorable change in Behavior (6.5 [95% CI: 2.0-11.0]). Older age predicted less favorable change in Mental Health (-0.8 [95% CI: -1.36 to -0.23] per year). Changes in liver enzymes and hepatitis B antigens, DNA, or symptom count were not related to changes in these subscale scores.
CONCLUSION: HRQoL was generally good and consistent across 5 years in youth with CHB.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:77 |
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Enthalten in: |
Journal of pediatric gastroenterology and nutrition - 77(2023), 6 vom: 01. Dez., Seite 713-719 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Schwarzenberg, Sarah Jane [VerfasserIn] |
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Links: |
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Themen: |
Journal Article |
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Anmerkungen: |
Date Completed 01.01.2024 Date Revised 12.03.2024 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1097/MPG.0000000000003957 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM362526516 |
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245 | 1 | 0 | |a Change in Health-Related Quality of Life in Youth with Chronic Hepatitis B Living in North America |b A 5-Year Cohort Study |
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500 | |a Date Revised 12.03.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2023 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. | ||
520 | |a BACKGROUND: Greater hepatitis-related symptomology is associated with lower health-related quality-of-life (HRQoL) among untreated youth with chronic hepatitis B (CHB). How HRQoL changes over time in this population is unknown | ||
520 | |a METHODS: Children from 7 hepatology centers in North America positive for hepatitis B surface antigen, not taking anti-viral therapy, were enrolled in the Hepatitis B Research Network. A validated self-report HRQoL measure, the Child Health Questionnaire Child Report (CHQ-CF87), was completed annually by participants 10-17 years, with demographic variables, liver disease symptoms, and laboratory tests. Linear mixed-effects models were used to evaluate the 10 CHQ-CF87 subscale scores over 5 years among participants who completed the CHQ-CF87 at least twice | ||
520 | |a RESULTS: Participants (N = 174) completed the CHQ-CF87 a median of 4 times. Median age was 12 years (interquartile range: 10-14) at baseline; 60% were female, 79% Asian, and 47% adopted. The CHQ-CF87 subscale scores were high at baseline (median range: 75.4-100) and did not differ by time point, except for the Family Activities subscale (mean [95% CI]: 82.3 [79.8-84.8] at baseline; 90.8 [86.1-94.6] week 240). Most subscale scores lacked sufficient individual-level variability in change over time to evaluate predictors. Being White versus Asian predicted a more favorable change in Behavior (6.5 [95% CI: 2.0-11.0]). Older age predicted less favorable change in Mental Health (-0.8 [95% CI: -1.36 to -0.23] per year). Changes in liver enzymes and hepatitis B antigens, DNA, or symptom count were not related to changes in these subscale scores | ||
520 | |a CONCLUSION: HRQoL was generally good and consistent across 5 years in youth with CHB | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, N.I.H., Extramural | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
700 | 1 | |a King, Wendy C |e verfasserin |4 aut | |
700 | 1 | |a Ling, Simon C |e verfasserin |4 aut | |
700 | 1 | |a Murray, Karen F |e verfasserin |4 aut | |
700 | 1 | |a Mogul, Douglas |e verfasserin |4 aut | |
700 | 1 | |a Rosenthal, Philip |e verfasserin |4 aut | |
700 | 1 | |a Rodriguez-Baez, Norberto |e verfasserin |4 aut | |
700 | 1 | |a Teckman, Jeffrey |e verfasserin |4 aut | |
700 | 1 | |a Schwarz, Kathleen B |e verfasserin |4 aut | |
700 | 0 | |a Hepatitis B Research Network (HBRN) |e verfasserin |4 aut | |
700 | 1 | |a Li, Hongxia |e investigator |4 oth | |
700 | 1 | |a Anders, Robert |e investigator |4 oth | |
700 | 1 | |a Imteyaz, Hejab |e investigator |4 oth | |
700 | 1 | |a Lee, Peter |e investigator |4 oth | |
700 | 1 | |a Oshima, Kiyoko |e investigator |4 oth | |
700 | 1 | |a Kafka, Kim |e investigator |4 oth | |
700 | 1 | |a Islam, Naureen |e investigator |4 oth | |
700 | 1 | |a Swim, Shannon R |e investigator |4 oth | |
700 | 1 | |a Nagy, Rosemary A |e investigator |4 oth | |
700 | 1 | |a Cerkoski, Jacki |e investigator |4 oth | |
700 | 1 | |a Hau, Athena |e investigator |4 oth | |
700 | 1 | |a Yuan, Caitlin |e investigator |4 oth | |
700 | 1 | |a Swan, Rosemary |e investigator |4 oth | |
700 | 1 | |a O'Connor, Constance |e investigator |4 oth | |
700 | 1 | |a Rodgers-Augustyniak, Laurie A |e investigator |4 oth | |
700 | 1 | |a Montanye, Shirley |e investigator |4 oth | |
700 | 1 | |a Feier, Natasha |e investigator |4 oth | |
700 | 1 | |a Feier, Joel |e investigator |4 oth | |
700 | 1 | |a Fleck, Shannon |e investigator |4 oth | |
700 | 1 | |a Langlois, Camille |e investigator |4 oth | |
700 | 1 | |a Cooper, Kara L |e investigator |4 oth | |
700 | 1 | |a Hoofnagle, Jay H |e investigator |4 oth | |
700 | 1 | |a Sherker, Averell H |e investigator |4 oth | |
700 | 1 | |a Doo, Edward |e investigator |4 oth | |
700 | 1 | |a Torrance, Rebecca J |e investigator |4 oth | |
700 | 1 | |a Hall, Sherry R |e investigator |4 oth | |
700 | 1 | |a Averbach, Frani |e investigator |4 oth | |
700 | 1 | |a Haller, Tamara |e investigator |4 oth | |
700 | 1 | |a Kelley, Stephanie |e investigator |4 oth | |
700 | 1 | |a Lalama, Christina M |e investigator |4 oth | |
700 | 1 | |a Lawlor, Sharon |e investigator |4 oth | |
700 | 1 | |a Lin, Hsing-Hua S |e investigator |4 oth | |
700 | 1 | |a Lombardero, Manuel |e investigator |4 oth | |
700 | 1 | |a Pelesko, Andrew |e investigator |4 oth | |
700 | 1 | |a Stoliker, Donna |e investigator |4 oth | |
700 | 1 | |a Weiner, Melissa |e investigator |4 oth | |
700 | 1 | |a Zadorozny, Ella |e investigator |4 oth | |
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