β1-adrenergic receptor polymorphisms : a possible genetic predictor of bisoprolol response in acute coronary syndrome
© 2023 The Authors..
Aim: To investigate the association between beta1-adrenergic receptor (ADRB1) polymorphisms and response to bisoprolol treatment in beta-blocker naive patients with acute coronary syndrome (ACS).
Patients & methods: Seventy-seven patients received bisoprolol for four weeks. Blood pressure and heart rate were measured at baseline and during treatment. TaqMan allelic discrimination method was utilized for ADRB1 Ser49Gly and Arg389Gly genotyping.
Results: Arg389Arg carriers showed greater reductions in systolic and diastolic blood pressure (-8.5% ± 7.8% vs -0.76% ± 8.7%, p = 0.000218), and (-9.5% ± 9.7% vs -0.80% ± 11.5%, p = 0.000149), respectively, compared with Gly389 carriers. No statistical difference was found for study's outcomes based on codon 49.
Conclusion: Arg389Gly polymorphism is a promising bisoprolol response predictor in ACS patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Future science OA - 9(2023), 10 vom: 15. Dez., Seite FSO895 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fayed, Mohamed S [VerfasserIn] |
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| Links: |
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| Themen: |
ADRB1 |
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| Anmerkungen: |
Date Revised 20.10.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.2144/fsoa-2023-0113 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM362496870 |
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| 245 | 1 | 0 | |a β1-adrenergic receptor polymorphisms |b a possible genetic predictor of bisoprolol response in acute coronary syndrome |
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| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2023 The Authors. | ||
| 520 | |a Aim: To investigate the association between beta1-adrenergic receptor (ADRB1) polymorphisms and response to bisoprolol treatment in beta-blocker naive patients with acute coronary syndrome (ACS) | ||
| 520 | |a Patients & methods: Seventy-seven patients received bisoprolol for four weeks. Blood pressure and heart rate were measured at baseline and during treatment. TaqMan allelic discrimination method was utilized for ADRB1 Ser49Gly and Arg389Gly genotyping | ||
| 520 | |a Results: Arg389Arg carriers showed greater reductions in systolic and diastolic blood pressure (-8.5% ± 7.8% vs -0.76% ± 8.7%, p = 0.000218), and (-9.5% ± 9.7% vs -0.80% ± 11.5%, p = 0.000149), respectively, compared with Gly389 carriers. No statistical difference was found for study's outcomes based on codon 49 | ||
| 520 | |a Conclusion: Arg389Gly polymorphism is a promising bisoprolol response predictor in ACS patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a ADRB1 | |
| 650 | 4 | |a Arg389Gly | |
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| 650 | 4 | |a heart rate | |
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| 700 | 1 | |a Sabri, Nagwa A |e verfasserin |4 aut | |
| 700 | 1 | |a Elkholy, Amal A |e verfasserin |4 aut | |
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