The impact of cellular environment on in vitro drug screening
© 2023 The Authors..
There are various reasons for drug failure in the developmental stage including toxicity, adverse effects and inefficacy. This is likely due to the differences in drug behavior between a simple and controlled cell culture system to that of a more complex whole organism environment. While the use of human phenotypical cells relevant to the condition may provide more accurate screening results, they are susceptible to producing false positives as cells are continuously influenced by constant chemical and physical interaction with the surrounding microenvironment. Therefore, several microenvironmental and pharmacomechanical aspects must be factored in during tissue culture drug screening.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Future science OA - 9(2023), 9 vom: 21. Okt., Seite FSO900 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Moldasheva, Aiman [VerfasserIn] |
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| Links: |
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| Themen: |
Cell culture |
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| Anmerkungen: |
Date Revised 28.09.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.2144/fsoa-2023-0027 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM362492522 |
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| 520 | |a There are various reasons for drug failure in the developmental stage including toxicity, adverse effects and inefficacy. This is likely due to the differences in drug behavior between a simple and controlled cell culture system to that of a more complex whole organism environment. While the use of human phenotypical cells relevant to the condition may provide more accurate screening results, they are susceptible to producing false positives as cells are continuously influenced by constant chemical and physical interaction with the surrounding microenvironment. Therefore, several microenvironmental and pharmacomechanical aspects must be factored in during tissue culture drug screening | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Aljofan, Mohamad |e verfasserin |4 aut | |
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