Efficacy of autologous dermal sheath cup cell transplantation in male and female pattern hair loss : A Single-Arm, Multi-Center, phase III equivalent clinical study
© 2023 Japanese Dermatological Association..
A previous, proof-of-concept clinical study suggested that dermal sheath cup cell injections into the affected areas of male/female pattern hair loss (PHL) may have some amelioratory effects, the clinical efficacy of which needs further examination. A phase III equivalent clinical study was conducted to further probe the therapeutic potential of this novel approach and verify its safety and efficacy in improving the appearance of PHL. Thirty-six participants with PHL were injected with dermal sheath cup cell harvested from non-affected occipital hair follicles twice in quarterly intervals. Global photographic assessment and phototrichogram were performed in a blinded manner. Patient-reported outcomes were assessed for 12 months. On global photographic assessment, 30% of the participants showed improvement. The analysis of phototricogram data detected the increases in the cumulative hair diameter, hair cross-sectional area, and mean hair diameter of 107.6 ± 152.6 μm/cm2 , 13069.1 ± 10960.7 μm2 /cm2 , and 0.9 ± 0.9 μm (ratios vs. baseline: +1.4%, +3.4%, and +2.2%), respectively. The female and high terminal hair ratio groups achieved better improvement. Of the total participants, 62.9% noted some degree of improvement. No serious adverse events were detected. This novel approach exhibited visible effects while ensuring safety and patient satisfaction. Therefore, it holds promise as a possible therapeutic option for treating PHL, especially in women.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:50 |
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| Enthalten in: |
The Journal of dermatology - 50(2023), 12 vom: 17. Dez., Seite 1539-1549 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Harada, Kazutoshi [VerfasserIn] |
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| Links: |
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| Themen: |
Autologous cell transplantation |
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| Anmerkungen: |
Date Completed 15.12.2023 Date Revised 15.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/1346-8138.16957 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM362490686 |
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| 100 | 1 | |a Harada, Kazutoshi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Efficacy of autologous dermal sheath cup cell transplantation in male and female pattern hair loss |b A Single-Arm, Multi-Center, phase III equivalent clinical study |
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| 520 | |a © 2023 Japanese Dermatological Association. | ||
| 520 | |a A previous, proof-of-concept clinical study suggested that dermal sheath cup cell injections into the affected areas of male/female pattern hair loss (PHL) may have some amelioratory effects, the clinical efficacy of which needs further examination. A phase III equivalent clinical study was conducted to further probe the therapeutic potential of this novel approach and verify its safety and efficacy in improving the appearance of PHL. Thirty-six participants with PHL were injected with dermal sheath cup cell harvested from non-affected occipital hair follicles twice in quarterly intervals. Global photographic assessment and phototrichogram were performed in a blinded manner. Patient-reported outcomes were assessed for 12 months. On global photographic assessment, 30% of the participants showed improvement. The analysis of phototricogram data detected the increases in the cumulative hair diameter, hair cross-sectional area, and mean hair diameter of 107.6 ± 152.6 μm/cm2 , 13069.1 ± 10960.7 μm2 /cm2 , and 0.9 ± 0.9 μm (ratios vs. baseline: +1.4%, +3.4%, and +2.2%), respectively. The female and high terminal hair ratio groups achieved better improvement. Of the total participants, 62.9% noted some degree of improvement. No serious adverse events were detected. This novel approach exhibited visible effects while ensuring safety and patient satisfaction. Therefore, it holds promise as a possible therapeutic option for treating PHL, especially in women | ||
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| 700 | 1 | |a Ohyama, Manabu |e verfasserin |4 aut | |
| 700 | 1 | |a Niiyama, Shiro |e verfasserin |4 aut | |
| 700 | 1 | |a Irisawa, Ryokichi |e verfasserin |4 aut | |
| 700 | 1 | |a Mae, Kenichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Mori, Miho |e verfasserin |4 aut | |
| 700 | 1 | |a Wakimoto, Hiroko |e verfasserin |4 aut | |
| 700 | 1 | |a Kinoshita-Ise, Misaki |e verfasserin |4 aut | |
| 700 | 1 | |a Fukuyama, Masahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Hayakawa, Reina |e verfasserin |4 aut | |
| 700 | 1 | |a Takagi, Masaya |e verfasserin |4 aut | |
| 700 | 1 | |a Yamazaki, Masako |e verfasserin |4 aut | |
| 700 | 1 | |a Miyoshi, Mami |e verfasserin |4 aut | |
| 700 | 1 | |a Nishikawa, Saori |e verfasserin |4 aut | |
| 700 | 1 | |a Sato, Seiji |e verfasserin |4 aut | |
| 700 | 1 | |a Nakazawa, Yosuke |e verfasserin |4 aut | |
| 700 | 1 | |a Sugimoto, Takaki |e verfasserin |4 aut | |
| 700 | 1 | |a Ogo, Masashi |e verfasserin |4 aut | |
| 700 | 1 | |a Tsuboi, Ryoji |e verfasserin |4 aut | |
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