Benefit of Nasal Douche in COVID-19 Patients with Recurrence of Positive SARS-CoV-2 Viral RNA
© 2023 Liao et al..
Purpose: The purpose was to review relevant clinical data and formulate recommendations supporting the use of saline as a simple rinse for an early reassuring intervention to reduce the occurrence of re-positive COVID-19 patients.
Methods: We conducted a single-centre retrospective cohort study, which enrolled patients with confirmed re-testing positive COVID-19 during 7-60 days after discharge from Third People's Hospital of Shenzhen. By one-to-two propensity score matching for age and sex, the control group of those not re-testing positive during the same period served as matched control.
Results: A total of 223 patients were included in our study, 94 in re-positive group and 129 in non-re-positive group. The result shows that the rates of nasal douche treatment in the non-re-positive group were considerably higher than that of the re-positive group. And the Ct value of nasal douche group increased faster than that of non-nasal douche group after the Ct value reaching ≥35. Further analysis revealed that the higher the Ct value at the time of readmission, the shorter the time of average Ct values to reach ≥35.
Conclusion: These findings suggest that nasal douche is beneficial to shorten the time of virus nucleic acid turning negative, thereby reducing the incidence of re-positive. The prevention and control of epidemics focuses on re-positive patients with Ct values <35.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
|---|---|
| Enthalten in: |
Infection and drug resistance - 16(2023) vom: 26., Seite 6269-6276 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Liao, Xuejiao [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Revised 28.09.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.2147/IDR.S421380 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM362465304 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM362465304 | ||
| 003 | DE-627 | ||
| 005 | 20231226091312.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2147/IDR.S421380 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1208.xml |
| 035 | |a (DE-627)NLM362465304 | ||
| 035 | |a (NLM)37750173 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Liao, Xuejiao |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Benefit of Nasal Douche in COVID-19 Patients with Recurrence of Positive SARS-CoV-2 Viral RNA |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 28.09.2023 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2023 Liao et al. | ||
| 520 | |a Purpose: The purpose was to review relevant clinical data and formulate recommendations supporting the use of saline as a simple rinse for an early reassuring intervention to reduce the occurrence of re-positive COVID-19 patients | ||
| 520 | |a Methods: We conducted a single-centre retrospective cohort study, which enrolled patients with confirmed re-testing positive COVID-19 during 7-60 days after discharge from Third People's Hospital of Shenzhen. By one-to-two propensity score matching for age and sex, the control group of those not re-testing positive during the same period served as matched control | ||
| 520 | |a Results: A total of 223 patients were included in our study, 94 in re-positive group and 129 in non-re-positive group. The result shows that the rates of nasal douche treatment in the non-re-positive group were considerably higher than that of the re-positive group. And the Ct value of nasal douche group increased faster than that of non-nasal douche group after the Ct value reaching ≥35. Further analysis revealed that the higher the Ct value at the time of readmission, the shorter the time of average Ct values to reach ≥35 | ||
| 520 | |a Conclusion: These findings suggest that nasal douche is beneficial to shorten the time of virus nucleic acid turning negative, thereby reducing the incidence of re-positive. The prevention and control of epidemics focuses on re-positive patients with Ct values <35 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a RT-PCR | |
| 650 | 4 | |a nasal douche | |
| 650 | 4 | |a re-positive | |
| 700 | 1 | |a Guan, Yuan |e verfasserin |4 aut | |
| 700 | 1 | |a Asakawa, Tetsuya |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Zixun |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Qingrong |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Zhenghua |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Shuting |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xiaobin |e verfasserin |4 aut | |
| 700 | 1 | |a Dong, Jingke |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Liping |e verfasserin |4 aut | |
| 700 | 1 | |a Deng, Jiayu |e verfasserin |4 aut | |
| 700 | 1 | |a Liao, Zhonghui |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Sumei |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Cheng |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Shuo |e verfasserin |4 aut | |
| 700 | 1 | |a Yi, Hongyang |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Song |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Hongzhou |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Infection and drug resistance |d 2008 |g 16(2023) vom: 26., Seite 6269-6276 |w (DE-627)NLM209374322 |x 1178-6973 |7 nnns |
| 773 | 1 | 8 | |g volume:16 |g year:2023 |g day:26 |g pages:6269-6276 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.2147/IDR.S421380 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 16 |j 2023 |b 26 |h 6269-6276 | ||