Host genetic variation at a locus near CHD1L impacts HIV sequence diversity in a South African population
IMPORTANCE: It has been previously shown that genetic variants near CHD1L on chromosome 1 are associated with reduced HIV VL in African populations. However, the impact of these variants on viral diversity and how they restrict viral replication are unknown. We report on a regional association analysis in a South African population and show evidence of selective pressure by variants near CHD1L on HIV RT and gag. Our findings provide further insight into how genetic variability at this locus contributes to host control of HIV in a South African population.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:97 |
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| Enthalten in: |
Journal of virology - 97(2023), 10 vom: 31. Okt., Seite e0095423 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Schulz, Vanessa E [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 03.01.2024 Date Revised 12.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1128/jvi.00954-23 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM362436754 |
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| 245 | 1 | 0 | |a Host genetic variation at a locus near CHD1L impacts HIV sequence diversity in a South African population |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a IMPORTANCE: It has been previously shown that genetic variants near CHD1L on chromosome 1 are associated with reduced HIV VL in African populations. However, the impact of these variants on viral diversity and how they restrict viral replication are unknown. We report on a regional association analysis in a South African population and show evidence of selective pressure by variants near CHD1L on HIV RT and gag. Our findings provide further insight into how genetic variability at this locus contributes to host control of HIV in a South African population | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a HIV | |
| 650 | 4 | |a HLA | |
| 650 | 4 | |a genome-to-genome analysis | |
| 650 | 4 | |a host genomics | |
| 650 | 4 | |a host-pathogen interaction | |
| 650 | 4 | |a viral genomics | |
| 650 | 4 | |a viral load | |
| 650 | 7 | |a CHD1L protein, human |2 NLM | |
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| 650 | 7 | |a DNA Helicases |2 NLM | |
| 650 | 7 | |a EC 3.6.4.- |2 NLM | |
| 650 | 7 | |a DNA-Binding Proteins |2 NLM | |
| 650 | 7 | |a HIV Reverse Transcriptase |2 NLM | |
| 650 | 7 | |a EC 2.7.7.49 |2 NLM | |
| 650 | 7 | |a gag Gene Products, Human Immunodeficiency Virus |2 NLM | |
| 700 | 1 | |a Tuff, Jeffrey F |e verfasserin |4 aut | |
| 700 | 1 | |a Tough, Riley H |e verfasserin |4 aut | |
| 700 | 1 | |a Lewis, Lara |e verfasserin |4 aut | |
| 700 | 1 | |a Chimukangara, Benjamin |e verfasserin |4 aut | |
| 700 | 1 | |a Garrett, Nigel |e verfasserin |4 aut | |
| 700 | 1 | |a Abdool Karim, Quarraisha |e verfasserin |4 aut | |
| 700 | 1 | |a Abdool Karim, Salim S |e verfasserin |4 aut | |
| 700 | 1 | |a McKinnon, Lyle R |e verfasserin |4 aut | |
| 700 | 1 | |a Kharsany, Ayesha B M |e verfasserin |4 aut | |
| 700 | 1 | |a McLaren, Paul J |e verfasserin |4 aut | |
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