Metabolic and Genetic Association of Vitamin D with Calcium Signaling and Insulin Resistance
© The Author(s), under exclusive licence to Association of Clinical Biochemists of India 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law..
Various evidences have unveiled the significance of Vitamin D in diverse processes which include its action in prevention of immune dysfunction, cancer and cardiometabolic disorders. Studies have confirmed the function of VD in controlling the expression of approximately nine hundred genes including gene expression of insulin. VD insufficiency may be linked with the pathogenesis of diseases that are associated with insulin resistance (IR) including diabetes as well as obesity. Thus, VD lowers IR-related disorders such as inflammation and oxidative stress. This review provides an insight regarding the molecular mechanism manifesting, how insufficiency of VD may be connected with the IR and diabetes. It also discusses the effect of VD in maintaining the Ca2+ levels in beta cells of the pancreas and in the tissues that are responsive to insulin.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:38 |
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| Enthalten in: |
Indian journal of clinical biochemistry : IJCB - 38(2023), 4 vom: 18. Okt., Seite 407-417 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tarfeen, Najeebul [VerfasserIn] |
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| Links: |
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| Themen: |
Calcium |
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| Anmerkungen: |
Date Revised 26.09.2023 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1007/s12291-022-01105-0 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a © The Author(s), under exclusive licence to Association of Clinical Biochemists of India 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. | ||
| 520 | |a Various evidences have unveiled the significance of Vitamin D in diverse processes which include its action in prevention of immune dysfunction, cancer and cardiometabolic disorders. Studies have confirmed the function of VD in controlling the expression of approximately nine hundred genes including gene expression of insulin. VD insufficiency may be linked with the pathogenesis of diseases that are associated with insulin resistance (IR) including diabetes as well as obesity. Thus, VD lowers IR-related disorders such as inflammation and oxidative stress. This review provides an insight regarding the molecular mechanism manifesting, how insufficiency of VD may be connected with the IR and diabetes. It also discusses the effect of VD in maintaining the Ca2+ levels in beta cells of the pancreas and in the tissues that are responsive to insulin | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Calcium | |
| 650 | 4 | |a Diabetes | |
| 650 | 4 | |a Insulin resistance (IR) | |
| 650 | 4 | |a Insulin sensitivity | |
| 650 | 4 | |a Vitamin D | |
| 650 | 4 | |a Vitamin D deficiency | |
| 700 | 1 | |a Nisa, Khair Ul |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmad, Mir Bilal |e verfasserin |4 aut | |
| 700 | 1 | |a Waza, Ajaz Ahmad |e verfasserin |4 aut | |
| 700 | 1 | |a Ganai, Bashir Ahmad |e verfasserin |4 aut | |
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