Quince seed mucilage/β-cyclodextrin/Mmt-Na+-co-poly (methacrylate) based pH-sensitive polymeric carriers for controlled delivery of Capecitabine
Copyright © 2023. Published by Elsevier B.V..
In current work, quince seed mucilage and β-Cyclodextrin based pH regulated hydrogels were developed using aqueous free radical polymerization to sustain Capecitabine release patterns and to overcome its drawbacks, such as high dose frequency, short half-life, and low bioavailability. Developed networks were subjected to thermal analysis, Fourier transforms infrared spectroscopy, powder x-ray diffraction, elemental analysis, scanning electron microscopy, equilibrium swelling, and in-vitro release investigations to assess the network system's stability, complexation, morphology, and pH responsiveness. Thermally stable pH-responsive cross-linked networks were formed. Nanocomposite hydrogels were prepared by incorporating Capecitabine-containing clay into the swollen hydrogels. All the formulations exhibited equilibrium swelling ranging from 67.98 % to 92.98 % at pH 7.4. Optimum Capecitabine loading (88.17 %) was noted in the case of hydrogels, while it was 74.27 % in nanocomposite hydrogels. Excellent gel content (65.88 %-93.56 %) was noticed among developed formulations. Elemental analysis ensured the successful incorporation of Capecitabine. Nanocomposite hydrogels released 80.02 % longer than hydrogels after 30 h. NC hydrogels had higher t1/2 (10.57 h), AUC (121.52 μg.h/ml), and MRT (18.95 h) than hydrogels in oral pharmacokinetics. These findings imply that the pH-responsive carrier system may improve Capecitabine efficacy and reduce dosing frequency in cancer therapy. Toxicity profiling proved the system's safety, non-toxicity, and biocompatibility.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:253 |
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| Enthalten in: |
International journal of biological macromolecules - 253(2023), Pt 4 vom: 31. Dez., Seite 127032 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yasmin, Tahira [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 29.11.2023 Date Revised 29.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijbiomac.2023.127032 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM362393729 |
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| 520 | |a Copyright © 2023. Published by Elsevier B.V. | ||
| 520 | |a In current work, quince seed mucilage and β-Cyclodextrin based pH regulated hydrogels were developed using aqueous free radical polymerization to sustain Capecitabine release patterns and to overcome its drawbacks, such as high dose frequency, short half-life, and low bioavailability. Developed networks were subjected to thermal analysis, Fourier transforms infrared spectroscopy, powder x-ray diffraction, elemental analysis, scanning electron microscopy, equilibrium swelling, and in-vitro release investigations to assess the network system's stability, complexation, morphology, and pH responsiveness. Thermally stable pH-responsive cross-linked networks were formed. Nanocomposite hydrogels were prepared by incorporating Capecitabine-containing clay into the swollen hydrogels. All the formulations exhibited equilibrium swelling ranging from 67.98 % to 92.98 % at pH 7.4. Optimum Capecitabine loading (88.17 %) was noted in the case of hydrogels, while it was 74.27 % in nanocomposite hydrogels. Excellent gel content (65.88 %-93.56 %) was noticed among developed formulations. Elemental analysis ensured the successful incorporation of Capecitabine. Nanocomposite hydrogels released 80.02 % longer than hydrogels after 30 h. NC hydrogels had higher t1/2 (10.57 h), AUC (121.52 μg.h/ml), and MRT (18.95 h) than hydrogels in oral pharmacokinetics. These findings imply that the pH-responsive carrier system may improve Capecitabine efficacy and reduce dosing frequency in cancer therapy. Toxicity profiling proved the system's safety, non-toxicity, and biocompatibility | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Capecitabine | |
| 650 | 4 | |a Montmorillonite sodium | |
| 650 | 4 | |a Nanocomposite | |
| 650 | 4 | |a Pharmacokinetic evaluation | |
| 650 | 4 | |a Quince seed mucilage | |
| 650 | 4 | |a β-CD | |
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| 650 | 7 | |a Capecitabine |2 NLM | |
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| 650 | 7 | |a Polymers |2 NLM | |
| 650 | 7 | |a Polysaccharides |2 NLM | |
| 650 | 7 | |a Hydrogels |2 NLM | |
| 650 | 7 | |a beta-Cyclodextrins |2 NLM | |
| 700 | 1 | |a Mahmood, Asif |e verfasserin |4 aut | |
| 700 | 1 | |a Farooq, Muhammad |e verfasserin |4 aut | |
| 700 | 1 | |a Rehman, Umaira |e verfasserin |4 aut | |
| 700 | 1 | |a Sarfraz, Rai Muhammad |e verfasserin |4 aut | |
| 700 | 1 | |a Ijaz, Hira |e verfasserin |4 aut | |
| 700 | 1 | |a Akram, Muhammad Rouf |e verfasserin |4 aut | |
| 700 | 1 | |a Boublia, Abir |e verfasserin |4 aut | |
| 700 | 1 | |a Salem Bekhit, Mounir M |e verfasserin |4 aut | |
| 700 | 1 | |a Ernst, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Benguerba, Yacine |e verfasserin |4 aut | |
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