Comparative analysis of characteristics and outcomes in hospitalized COVID-19 patients infected with different SARS-CoV-2 variants between January 2020 and April 2022 - A retrospective single-center cohort study
Copyright © 2023. Published by Elsevier Ltd..
BACKGROUND: Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, the roll-out of vaccines and therapeutic agents, as well as the emergence of novel SARS-CoV-2 variants, have shown significant effects on disease severity.
METHODS: Patients hospitalized at our center between January 2020 and April 2022 were attributed to subgroups depending on which SARS-CoV-2 variant was predominantly circulating in Germany: (i) Wild-type: January 1, 2020, to March 7, 2021, (ii) Alpha variant: August 3, 2021, to June 27, 2021, (iii) Delta variant: June 28, 2021, to December 26, 2021, and (iv) Omicron variant: December 27, 2021, to April 30, 2022.
RESULTS: Between January 2020 and April 2022, 1500 patients with SARS-CoV-2 infections were admitted to the University Medical Center Hamburg-Eppendorf. The rate of patients who were admitted to the intensive care unit (ICU) decreased from 31.2% (n = 223) in the wild-type group, 28.5% (n = 72) in the Alpha variant group, 18.8% (n = 67) in the Delta variant group, and 13.4% (n = 135) in the Omicron variant group. Also, in-hospital mortality decreased from 20.6% (n = 111) in the wild-type group, 17.5% (n = 30) in the Alpha variant group, 16.8% (n = 33) in the Delta variant group, and 6.6% (n = 39) in the Omicron variant group. The median duration of hospitalization was similar in all subgroups and ranged between 11 and 15 days throughout the pandemic.
CONCLUSIONS: In-hospital mortality and rate of ICU admission among hospitalized COVID-19 patients steadily decreased throughout the pandemic. However, the practically unchanged duration of hospitalization demonstrates the persistent burden of COVID-19 on the healthcare system.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
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| Enthalten in: |
Journal of infection and public health - 16(2023), 11 vom: 21. Nov., Seite 1806-1812 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Brehm, Thomas Theo [VerfasserIn] |
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| Links: |
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| Themen: |
Alpha variant |
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| Anmerkungen: |
Date Revised 22.10.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.jiph.2023.08.010 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Brehm, Thomas Theo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Comparative analysis of characteristics and outcomes in hospitalized COVID-19 patients infected with different SARS-CoV-2 variants between January 2020 and April 2022 - A retrospective single-center cohort study |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Revised 22.10.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2023. Published by Elsevier Ltd. | ||
| 520 | |a BACKGROUND: Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, the roll-out of vaccines and therapeutic agents, as well as the emergence of novel SARS-CoV-2 variants, have shown significant effects on disease severity | ||
| 520 | |a METHODS: Patients hospitalized at our center between January 2020 and April 2022 were attributed to subgroups depending on which SARS-CoV-2 variant was predominantly circulating in Germany: (i) Wild-type: January 1, 2020, to March 7, 2021, (ii) Alpha variant: August 3, 2021, to June 27, 2021, (iii) Delta variant: June 28, 2021, to December 26, 2021, and (iv) Omicron variant: December 27, 2021, to April 30, 2022 | ||
| 520 | |a RESULTS: Between January 2020 and April 2022, 1500 patients with SARS-CoV-2 infections were admitted to the University Medical Center Hamburg-Eppendorf. The rate of patients who were admitted to the intensive care unit (ICU) decreased from 31.2% (n = 223) in the wild-type group, 28.5% (n = 72) in the Alpha variant group, 18.8% (n = 67) in the Delta variant group, and 13.4% (n = 135) in the Omicron variant group. Also, in-hospital mortality decreased from 20.6% (n = 111) in the wild-type group, 17.5% (n = 30) in the Alpha variant group, 16.8% (n = 33) in the Delta variant group, and 6.6% (n = 39) in the Omicron variant group. The median duration of hospitalization was similar in all subgroups and ranged between 11 and 15 days throughout the pandemic | ||
| 520 | |a CONCLUSIONS: In-hospital mortality and rate of ICU admission among hospitalized COVID-19 patients steadily decreased throughout the pandemic. However, the practically unchanged duration of hospitalization demonstrates the persistent burden of COVID-19 on the healthcare system | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Alpha variant | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Delta variant | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Omicron variant | |
| 650 | 4 | |a SARS-CoV-2 | |
| 700 | 1 | |a Heyer, Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a Woo, Marcel S |e verfasserin |4 aut | |
| 700 | 1 | |a Fischer, Marlene |e verfasserin |4 aut | |
| 700 | 1 | |a van der Meirschen, Marc |e verfasserin |4 aut | |
| 700 | 1 | |a Wichmann, Dominic |e verfasserin |4 aut | |
| 700 | 1 | |a Jarczak, Dominik |e verfasserin |4 aut | |
| 700 | 1 | |a Roedl, Kevin |e verfasserin |4 aut | |
| 700 | 1 | |a Schmiedel, Stefan |e verfasserin |4 aut | |
| 700 | 1 | |a Addo, Marylyn M |e verfasserin |4 aut | |
| 700 | 1 | |a Lütgehetmann, Marc |e verfasserin |4 aut | |
| 700 | 1 | |a Christner, Martin |e verfasserin |4 aut | |
| 700 | 1 | |a Huber, Samuel |e verfasserin |4 aut | |
| 700 | 1 | |a Lohse, Ansgar W |e verfasserin |4 aut | |
| 700 | 1 | |a Kluge, Stefan |e verfasserin |4 aut | |
| 700 | 1 | |a Schulze Zur Wiesch, Julian |e verfasserin |4 aut | |
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