Uncovering the genetic architecture of parallel evolution
© 2023 The Authors. Molecular Ecology published by John Wiley & Sons Ltd..
Identifying the genetic architecture underlying adaptive traits is exceptionally challenging in natural populations. This is because associations between traits not only mask the targets of selection but also create correlated patterns of genomic divergence that hinder our ability to isolate causal genetic effects. Here, we examine the repeated evolution of components of the auxin pathway that have contributed to the replicated loss of gravitropism (i.e. the ability of a plant to bend in response to gravity) in multiple populations of the Senecio lautus species complex in Australia. We use a powerful approach which combines parallel population genomics with association mapping in a Multiparent Advanced Generation Inter-Cross (MAGIC) population to break down genetic and trait correlations to reveal how adaptive traits evolve during replicated evolution. We sequenced auxin and shoot gravitropism-related gene regions in 80 individuals from six natural populations (three parallel divergence events) and 133 individuals from a MAGIC population derived from two of the recently diverged natural populations. We show that artificial tail selection on gravitropism in the MAGIC population recreates patterns of parallel divergence in the auxin pathway in the natural populations. We reveal a set of 55 auxin gene regions that have evolved repeatedly during the evolution of the species, of which 50 are directly associated with gravitropism divergence in the MAGIC population. Our work creates a strong link between patterns of genomic divergence and trait variation contributing to replicated evolution by natural selection, paving the way to understand the origin and maintenance of adaptations in natural populations.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
|---|---|
| Enthalten in: |
Molecular ecology - 32(2023), 20 vom: 23. Okt., Seite 5575-5589 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
James, Maddie E [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 11.10.2023 Date Revised 11.10.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1111/mec.17134 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM362371660 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM362371660 | ||
| 003 | DE-627 | ||
| 005 | 20231226091111.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/mec.17134 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1207.xml |
| 035 | |a (DE-627)NLM362371660 | ||
| 035 | |a (NLM)37740681 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a James, Maddie E |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Uncovering the genetic architecture of parallel evolution |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 11.10.2023 | ||
| 500 | |a Date Revised 11.10.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 The Authors. Molecular Ecology published by John Wiley & Sons Ltd. | ||
| 520 | |a Identifying the genetic architecture underlying adaptive traits is exceptionally challenging in natural populations. This is because associations between traits not only mask the targets of selection but also create correlated patterns of genomic divergence that hinder our ability to isolate causal genetic effects. Here, we examine the repeated evolution of components of the auxin pathway that have contributed to the replicated loss of gravitropism (i.e. the ability of a plant to bend in response to gravity) in multiple populations of the Senecio lautus species complex in Australia. We use a powerful approach which combines parallel population genomics with association mapping in a Multiparent Advanced Generation Inter-Cross (MAGIC) population to break down genetic and trait correlations to reveal how adaptive traits evolve during replicated evolution. We sequenced auxin and shoot gravitropism-related gene regions in 80 individuals from six natural populations (three parallel divergence events) and 133 individuals from a MAGIC population derived from two of the recently diverged natural populations. We show that artificial tail selection on gravitropism in the MAGIC population recreates patterns of parallel divergence in the auxin pathway in the natural populations. We reveal a set of 55 auxin gene regions that have evolved repeatedly during the evolution of the species, of which 50 are directly associated with gravitropism divergence in the MAGIC population. Our work creates a strong link between patterns of genomic divergence and trait variation contributing to replicated evolution by natural selection, paving the way to understand the origin and maintenance of adaptations in natural populations | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Multiparent Advanced Generation Inter-Cross (MAGIC) population | |
| 650 | 4 | |a association mapping | |
| 650 | 4 | |a auxin pathway | |
| 650 | 4 | |a parallel evolution | |
| 650 | 4 | |a recombinant population | |
| 650 | 4 | |a shoot gravitropism | |
| 650 | 7 | |a Indoleacetic Acids |2 NLM | |
| 700 | 1 | |a Allsopp, Robin N |e verfasserin |4 aut | |
| 700 | 1 | |a Groh, Jeffrey S |e verfasserin |4 aut | |
| 700 | 1 | |a Kaur, Avneet |e verfasserin |4 aut | |
| 700 | 1 | |a Wilkinson, Melanie J |e verfasserin |4 aut | |
| 700 | 1 | |a Ortiz-Barrientos, Daniel |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Molecular ecology |d 1993 |g 32(2023), 20 vom: 23. Okt., Seite 5575-5589 |w (DE-627)NLM013262866 |x 1365-294X |7 nnns |
| 773 | 1 | 8 | |g volume:32 |g year:2023 |g number:20 |g day:23 |g month:10 |g pages:5575-5589 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1111/mec.17134 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 32 |j 2023 |e 20 |b 23 |c 10 |h 5575-5589 | ||