Diarrhoea and constipation during artificial nutrition in intensive care unit : A prospective observational study
Copyright © 2023 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved..
PURPOSE: To describe the occurrence of gastrointestinal (GI) complications, specifically diarrhoea and constipation, in artificially (enterally or parenterally) fed critically ill patients within their first seven-day stay in Intensive Care Unit (ICU).
METHODS: Observational prospective study conducted from September 1st to October 30th, 2019 and from August 1st to October 30th, 2021, in an ICU of a 1000-bed third-level hospital. General characteristics, nutritional variables, and medications administered were recorded and analysed. This study was registered on ClinicalTrials.gov (Identifier: NCT05473546).
RESULTS: In total, 100 critically ill patients were included. Diarrhoea was present in 44 patients (44.0%), while constipation occurred in 22 (22.0%) patients. Patients with diarrhoea were generally those admitted for respiratory failure, whereas patients without diarrhoea were mostly affected by neurological disorders (22.7% vs 25%, respectively; p = 0.002). Likewise, patients with constipation were primarily those admitted for trauma (36.4%). Trauma patients were almost 24 times more likely to be constipated than patients with respiratory failure (OR 23.99, CI 1.38-418.0) and patients receiving diuretics were over 16 times more likely to have diarrhoea than patients not receiving diuretics (OR 16.25, IC 1.89-139.86).
CONCLUSION: GI complications of enteral nutrition represent still a very common issue in ICU. The main predictor of constipation was an admission for trauma whereas the main predictor of diarrhoea was the use of diuretics. Clinicians should consider and integrate these findings into more personalized nutritional and management protocols to avoid gastrointestinal complications.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:57 |
|---|---|
| Enthalten in: |
Clinical nutrition ESPEN - 57(2023) vom: 01. Okt., Seite 375-380 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Danielis, Matteo [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Artificial nutrition |
|---|
| Anmerkungen: |
Date Completed 25.09.2023 Date Revised 25.09.2023 published: Print-Electronic ClinicalTrials.gov: NCT05473546 Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.clnesp.2023.07.007 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM362361878 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM362361878 | ||
| 003 | DE-627 | ||
| 005 | 20231226091059.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.clnesp.2023.07.007 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1207.xml |
| 035 | |a (DE-627)NLM362361878 | ||
| 035 | |a (NLM)37739681 | ||
| 035 | |a (PII)S2405-4577(23)00541-7 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Danielis, Matteo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Diarrhoea and constipation during artificial nutrition in intensive care unit |b A prospective observational study |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 25.09.2023 | ||
| 500 | |a Date Revised 25.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ClinicalTrials.gov: NCT05473546 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. | ||
| 520 | |a PURPOSE: To describe the occurrence of gastrointestinal (GI) complications, specifically diarrhoea and constipation, in artificially (enterally or parenterally) fed critically ill patients within their first seven-day stay in Intensive Care Unit (ICU) | ||
| 520 | |a METHODS: Observational prospective study conducted from September 1st to October 30th, 2019 and from August 1st to October 30th, 2021, in an ICU of a 1000-bed third-level hospital. General characteristics, nutritional variables, and medications administered were recorded and analysed. This study was registered on ClinicalTrials.gov (Identifier: NCT05473546) | ||
| 520 | |a RESULTS: In total, 100 critically ill patients were included. Diarrhoea was present in 44 patients (44.0%), while constipation occurred in 22 (22.0%) patients. Patients with diarrhoea were generally those admitted for respiratory failure, whereas patients without diarrhoea were mostly affected by neurological disorders (22.7% vs 25%, respectively; p = 0.002). Likewise, patients with constipation were primarily those admitted for trauma (36.4%). Trauma patients were almost 24 times more likely to be constipated than patients with respiratory failure (OR 23.99, CI 1.38-418.0) and patients receiving diuretics were over 16 times more likely to have diarrhoea than patients not receiving diuretics (OR 16.25, IC 1.89-139.86) | ||
| 520 | |a CONCLUSION: GI complications of enteral nutrition represent still a very common issue in ICU. The main predictor of constipation was an admission for trauma whereas the main predictor of diarrhoea was the use of diuretics. Clinicians should consider and integrate these findings into more personalized nutritional and management protocols to avoid gastrointestinal complications | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Artificial nutrition | |
| 650 | 4 | |a Diuretics | |
| 650 | 4 | |a Gastrointestinal disfunction | |
| 650 | 4 | |a ICU | |
| 650 | 4 | |a Mechanical ventilation | |
| 650 | 4 | |a Trauma | |
| 650 | 7 | |a Diuretics |2 NLM | |
| 700 | 1 | |a Mattiussi, Elisa |e verfasserin |4 aut | |
| 700 | 1 | |a Piani, Tommaso |e verfasserin |4 aut | |
| 700 | 1 | |a Iacobucci, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Tullio, Annarita |e verfasserin |4 aut | |
| 700 | 1 | |a Molfino, Alessio |e verfasserin |4 aut | |
| 700 | 1 | |a Vetrugno, Luigi |e verfasserin |4 aut | |
| 700 | 1 | |a Deana, Cristian |e verfasserin |4 aut | |
| 700 | 0 | |a Nutriti Study Group |e verfasserin |4 aut | |
| 700 | 1 | |a Capolicchio, Luca |e investigator |4 oth | |
| 700 | 1 | |a Castriotta, Luigi |e investigator |4 oth | |
| 700 | 1 | |a Del Pin, Massimo |e investigator |4 oth | |
| 700 | 1 | |a Di Bartolo, Elena |e investigator |4 oth | |
| 700 | 1 | |a Gazziola, Paola |e investigator |4 oth | |
| 700 | 1 | |a Gigante, Filippo |e investigator |4 oth | |
| 700 | 1 | |a Ruja, Elena |e investigator |4 oth | |
| 700 | 1 | |a Veizi, Stela |e investigator |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical nutrition ESPEN |d 2015 |g 57(2023) vom: 01. Okt., Seite 375-380 |w (DE-627)NLM250070626 |x 2405-4577 |7 nnns |
| 773 | 1 | 8 | |g volume:57 |g year:2023 |g day:01 |g month:10 |g pages:375-380 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.clnesp.2023.07.007 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 57 |j 2023 |b 01 |c 10 |h 375-380 | ||