Findings on High Resolution Computed Tomography in Symptomatic Veterans with Deployment-Related Lung Disease
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved..
PURPOSE: Military deployment to dusty, austere environments in Southwest Asia and Afghanistan is associated with symptomatic airways diseases including asthma and bronchiolitis. The utility of chest high-resolution computed tomographic (HRCT) imaging in lung disease diagnosis in this population is poorly understood. We investigated visual assessment of HRCT for identifying deployment-related lung disease compared with healthy controls.
MATERIALS AND METHODS: Chest HRCT images from 46 healthy controls and 45 symptomatic deployed military personnel with clinically confirmed asthma and/or biopsy-confirmed distal lung disease were scored by 3 independent thoracic radiologists. We compared demographic and clinical characteristics and frequency of imaging findings between deployers and controls, and between deployers with asthma and those with biopsy-confirmed distal lung disease, using χ2, Fisher exact or t tests, and logistic regression where appropriate. We also analyzed inter-rater agreement for imaging findings.
RESULTS: Expiratory air trapping was the only chest CT imaging finding that was significantly more frequent in deployers compared with controls. None of the 24 deployers with biopsy-confirmed bronchiolitis and/or granulomatous pneumonitis had HRCT findings of inspiratory mosaic attenuation or centrilobular nodularity. Only 2 of 21 with biopsy-proven emphysema had emphysema on HRCT.
CONCLUSIONS: Compared with surgical lung biopsy, visual assessment of HRCT showed few abnormalities in this small cohort of previously deployed symptomatic veterans with normal or near-normal spirometry.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
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| Enthalten in: |
Journal of thoracic imaging - (2023) vom: 15. Sept. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rose, Cecile S [VerfasserIn] |
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Date Revised 19.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1097/RTI.0000000000000742 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM362294143 |
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| 245 | 1 | 0 | |a Findings on High Resolution Computed Tomography in Symptomatic Veterans with Deployment-Related Lung Disease |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. | ||
| 520 | |a PURPOSE: Military deployment to dusty, austere environments in Southwest Asia and Afghanistan is associated with symptomatic airways diseases including asthma and bronchiolitis. The utility of chest high-resolution computed tomographic (HRCT) imaging in lung disease diagnosis in this population is poorly understood. We investigated visual assessment of HRCT for identifying deployment-related lung disease compared with healthy controls | ||
| 520 | |a MATERIALS AND METHODS: Chest HRCT images from 46 healthy controls and 45 symptomatic deployed military personnel with clinically confirmed asthma and/or biopsy-confirmed distal lung disease were scored by 3 independent thoracic radiologists. We compared demographic and clinical characteristics and frequency of imaging findings between deployers and controls, and between deployers with asthma and those with biopsy-confirmed distal lung disease, using χ2, Fisher exact or t tests, and logistic regression where appropriate. We also analyzed inter-rater agreement for imaging findings | ||
| 520 | |a RESULTS: Expiratory air trapping was the only chest CT imaging finding that was significantly more frequent in deployers compared with controls. None of the 24 deployers with biopsy-confirmed bronchiolitis and/or granulomatous pneumonitis had HRCT findings of inspiratory mosaic attenuation or centrilobular nodularity. Only 2 of 21 with biopsy-proven emphysema had emphysema on HRCT | ||
| 520 | |a CONCLUSIONS: Compared with surgical lung biopsy, visual assessment of HRCT showed few abnormalities in this small cohort of previously deployed symptomatic veterans with normal or near-normal spirometry | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Zell-Baran, Lauren M |e verfasserin |4 aut | |
| 700 | 1 | |a Cool, Carlyne |e verfasserin |4 aut | |
| 700 | 1 | |a Moore, Camille M |e verfasserin |4 aut | |
| 700 | 1 | |a Wolff, Jenna |e verfasserin |4 aut | |
| 700 | 1 | |a Oh, Andrea S |e verfasserin |4 aut | |
| 700 | 1 | |a Koelsch, Tilman |e verfasserin |4 aut | |
| 700 | 1 | |a Richards, John C |e verfasserin |4 aut | |
| 700 | 1 | |a Krefft, Silpa D |e verfasserin |4 aut | |
| 700 | 1 | |a Wilson, Carla G |e verfasserin |4 aut | |
| 700 | 1 | |a Lynch, David A |e verfasserin |4 aut | |
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