Donor-derived cell free DNA as a biomarker in kidney transplantation
The early detection of acute rejection in the allograft is important as it provides an opportunity for timely therapeutic intervention in order to preserve graft function and achieve longer graft survival. Donor-derived cell-free DNA (dd-cfDNA) has emerged as a new biomarker in the field of kidney transplantation. In this review, we used data from various studies to examine the role of dd-cfDNA in comparison to creatinine and donor-specific antibodies in the early detection of transplant rejection. We also reviewed the use of dd-cfDNA in other organ transplants as well as the challenges and potential future direction for dd-cfDNA as a diagnostic tool.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
|---|---|
| Enthalten in: |
Pharmacogenomics - 24(2023), 14 vom: 21. Sept., Seite 771-780 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Abdulhadi, Tarek [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Biomarker |
|---|
| Anmerkungen: |
Date Revised 23.10.2023 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.2217/pgs-2023-0138 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM362291055 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM362291055 | ||
| 003 | DE-627 | ||
| 005 | 20231226090929.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2217/pgs-2023-0138 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1207.xml |
| 035 | |a (DE-627)NLM362291055 | ||
| 035 | |a (NLM)37732393 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Abdulhadi, Tarek |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Donor-derived cell free DNA as a biomarker in kidney transplantation |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 23.10.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a The early detection of acute rejection in the allograft is important as it provides an opportunity for timely therapeutic intervention in order to preserve graft function and achieve longer graft survival. Donor-derived cell-free DNA (dd-cfDNA) has emerged as a new biomarker in the field of kidney transplantation. In this review, we used data from various studies to examine the role of dd-cfDNA in comparison to creatinine and donor-specific antibodies in the early detection of transplant rejection. We also reviewed the use of dd-cfDNA in other organ transplants as well as the challenges and potential future direction for dd-cfDNA as a diagnostic tool | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a biomarker | |
| 650 | 4 | |a cell-free DNA | |
| 650 | 4 | |a cfDNA | |
| 650 | 4 | |a ddcfDNA | |
| 650 | 4 | |a donor derived cell-free DNA | |
| 650 | 4 | |a kidney | |
| 650 | 4 | |a rejection | |
| 650 | 4 | |a transplant | |
| 700 | 1 | |a Alrata, Louai |e verfasserin |4 aut | |
| 700 | 1 | |a Dubrawka, Casey |e verfasserin |4 aut | |
| 700 | 1 | |a Amurao, Gwendolyn |e verfasserin |4 aut | |
| 700 | 1 | |a Kalipatnapu, Sri Mahathi |e verfasserin |4 aut | |
| 700 | 1 | |a Isaac, Che |e verfasserin |4 aut | |
| 700 | 1 | |a Rodrigues, Shelden |e verfasserin |4 aut | |
| 700 | 1 | |a Flores, Karen Marie |e verfasserin |4 aut | |
| 700 | 1 | |a Alsabbagh, Dema Yaseen |e verfasserin |4 aut | |
| 700 | 1 | |a Alomar, Omar |e verfasserin |4 aut | |
| 700 | 1 | |a Alhamad, Tarek |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pharmacogenomics |d 2000 |g 24(2023), 14 vom: 21. Sept., Seite 771-780 |w (DE-627)NLM111671396 |x 1744-8042 |7 nnns |
| 773 | 1 | 8 | |g volume:24 |g year:2023 |g number:14 |g day:21 |g month:09 |g pages:771-780 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.2217/pgs-2023-0138 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 24 |j 2023 |e 14 |b 21 |c 09 |h 771-780 | ||