A comprehensive review of genetic causes of obesity
© 2023. Children's Hospital, Zhejiang University School of Medicine..
BACKGROUND: Obesity is a multifactorial chronic disease with a high, increasing worldwide prevalence. Genetic causes account for 7% of the cases in children with extreme obesity.
DATA SOURCES: This narrative review was conducted by searching for papers published in the PubMed/MEDLINE, Embase and SciELO databases and included 161 articles. The search used the following search terms: "obesity", "obesity and genetics", "leptin", "Prader-Willi syndrome", and "melanocortins". The types of studies included were systematic reviews, clinical trials, prospective cohort studies, cross-sectional and prospective studies, narrative reviews, and case reports.
RESULTS: The leptin-melanocortin pathway is primarily responsible for the regulation of appetite and body weight. However, several important aspects of the pathophysiology of obesity remain unknown. Genetic causes of obesity can be grouped into syndromic, monogenic, and polygenic causes and should be assessed in children with extreme obesity before the age of 5 years, hyperphagia, or a family history of extreme obesity. A microarray study, an analysis of the melanocortin type 4 receptor gene mutations and leptin levels should be performed for this purpose. There are three therapeutic levels: lifestyle modifications, pharmacological treatment, and bariatric surgery.
CONCLUSIONS: Genetic study technologies are in constant development; however, we are still far from having a personalized approach to genetic causes of obesity. A significant proportion of the affected individuals are associated with genetic causes; however, there are still barriers to its approach, as it continues to be underdiagnosed. Video Abstract (MP4 1041807 KB).
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
|---|---|
| Enthalten in: |
World journal of pediatrics : WJP - 20(2024), 1 vom: 06. Jan., Seite 26-39 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Concepción-Zavaleta, Marcio José [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Journal Article |
|---|
| Anmerkungen: |
Date Completed 31.01.2024 Date Revised 25.02.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1007/s12519-023-00757-z |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM362221529 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM362221529 | ||
| 003 | DE-627 | ||
| 005 | 20240229151451.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s12519-023-00757-z |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1305.xml |
| 035 | |a (DE-627)NLM362221529 | ||
| 035 | |a (NLM)37725322 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Concepción-Zavaleta, Marcio José |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A comprehensive review of genetic causes of obesity |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 31.01.2024 | ||
| 500 | |a Date Revised 25.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. Children's Hospital, Zhejiang University School of Medicine. | ||
| 520 | |a BACKGROUND: Obesity is a multifactorial chronic disease with a high, increasing worldwide prevalence. Genetic causes account for 7% of the cases in children with extreme obesity | ||
| 520 | |a DATA SOURCES: This narrative review was conducted by searching for papers published in the PubMed/MEDLINE, Embase and SciELO databases and included 161 articles. The search used the following search terms: "obesity", "obesity and genetics", "leptin", "Prader-Willi syndrome", and "melanocortins". The types of studies included were systematic reviews, clinical trials, prospective cohort studies, cross-sectional and prospective studies, narrative reviews, and case reports | ||
| 520 | |a RESULTS: The leptin-melanocortin pathway is primarily responsible for the regulation of appetite and body weight. However, several important aspects of the pathophysiology of obesity remain unknown. Genetic causes of obesity can be grouped into syndromic, monogenic, and polygenic causes and should be assessed in children with extreme obesity before the age of 5 years, hyperphagia, or a family history of extreme obesity. A microarray study, an analysis of the melanocortin type 4 receptor gene mutations and leptin levels should be performed for this purpose. There are three therapeutic levels: lifestyle modifications, pharmacological treatment, and bariatric surgery | ||
| 520 | |a CONCLUSIONS: Genetic study technologies are in constant development; however, we are still far from having a personalized approach to genetic causes of obesity. A significant proportion of the affected individuals are associated with genetic causes; however, there are still barriers to its approach, as it continues to be underdiagnosed. Video Abstract (MP4 1041807 KB) | ||
| 650 | 4 | |a Video-Audio Media | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Leptin | |
| 650 | 4 | |a Melanocortin | |
| 650 | 4 | |a Obesity | |
| 650 | 4 | |a Prader-Willi syndrome | |
| 650 | 4 | |a Precision medicine | |
| 650 | 7 | |a Leptin |2 NLM | |
| 650 | 7 | |a Melanocortins |2 NLM | |
| 700 | 1 | |a Quiroz-Aldave, Juan Eduardo |e verfasserin |4 aut | |
| 700 | 1 | |a Durand-Vásquez, María Del Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a Gamarra-Osorio, Elman Rolando |e verfasserin |4 aut | |
| 700 | 1 | |a Valencia de la Cruz, Juan Del Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a Barrueto-Callirgos, Claudia Mercedes |e verfasserin |4 aut | |
| 700 | 1 | |a Puelles-León, Susan Luciana |e verfasserin |4 aut | |
| 700 | 1 | |a Alvarado-León, Elena de Jesús |e verfasserin |4 aut | |
| 700 | 1 | |a Leiva-Cabrera, Frans |e verfasserin |4 aut | |
| 700 | 1 | |a Zavaleta-Gutiérrez, Francisca Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Concepción-Urteaga, Luis Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Paz-Ibarra, José |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t World journal of pediatrics : WJP |d 2008 |g 20(2024), 1 vom: 06. Jan., Seite 26-39 |w (DE-627)NLM178830402 |x 1867-0687 |7 nnns |
| 773 | 1 | 8 | |g volume:20 |g year:2024 |g number:1 |g day:06 |g month:01 |g pages:26-39 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s12519-023-00757-z |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 20 |j 2024 |e 1 |b 06 |c 01 |h 26-39 | ||