Two pregnant women with immune-mediated thrombotic thrombocytopenic purpura : A case report
© 2023 Japan Society of Obstetrics and Gynecology..
Thrombotic thrombocytopenic purpura (TTP) during pregnancy is life-threatening. We encountered two pregnant women with immune-mediated TTP (iTTP). A 40-year-old primigravida woman was referred at 19 gestational weeks (GWs) owing to iTTP. She received plasma exchange (PE) and steroid therapies and delivered a live infant at 27 GWs by cesarean delivery. A 29-year-old primigravida woman was referred owing to intrauterine fetal death and thrombocytopenia at 20 GWs. She was diagnosed with iTTP and received PE therapy. She required additional PE and steroid therapies owing to relapse. Before her second pregnancy, she received prednisolone and hydroxychloroquine according to the therapy for systemic lupus erythematosus (SLE). She had induced labor at 37 GWs owing to decrease plasma level of a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 13 (ADAMTS13) activity. Close monitoring of plasma ADAMTS13 activity level and treatments for underlying SLE may prevent iTTP relapse and lead to a good prognosis.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:49 |
|---|---|
| Enthalten in: |
The journal of obstetrics and gynaecology research - 49(2023), 12 vom: 18. Dez., Seite 2969-2974 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Uchida, Akiko [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
ADAMTS13 |
|---|
| Anmerkungen: |
Date Completed 05.12.2023 Date Revised 05.12.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1111/jog.15793 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM362204926 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM362204926 | ||
| 003 | DE-627 | ||
| 005 | 20231226090744.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/jog.15793 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1207.xml |
| 035 | |a (DE-627)NLM362204926 | ||
| 035 | |a (NLM)37723661 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Uchida, Akiko |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Two pregnant women with immune-mediated thrombotic thrombocytopenic purpura |b A case report |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 05.12.2023 | ||
| 500 | |a Date Revised 05.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 Japan Society of Obstetrics and Gynecology. | ||
| 520 | |a Thrombotic thrombocytopenic purpura (TTP) during pregnancy is life-threatening. We encountered two pregnant women with immune-mediated TTP (iTTP). A 40-year-old primigravida woman was referred at 19 gestational weeks (GWs) owing to iTTP. She received plasma exchange (PE) and steroid therapies and delivered a live infant at 27 GWs by cesarean delivery. A 29-year-old primigravida woman was referred owing to intrauterine fetal death and thrombocytopenia at 20 GWs. She was diagnosed with iTTP and received PE therapy. She required additional PE and steroid therapies owing to relapse. Before her second pregnancy, she received prednisolone and hydroxychloroquine according to the therapy for systemic lupus erythematosus (SLE). She had induced labor at 37 GWs owing to decrease plasma level of a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 13 (ADAMTS13) activity. Close monitoring of plasma ADAMTS13 activity level and treatments for underlying SLE may prevent iTTP relapse and lead to a good prognosis | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a ADAMTS13 | |
| 650 | 4 | |a immune-mediated thrombotic thrombocytopenic purpura | |
| 650 | 4 | |a plasma exchange | |
| 650 | 4 | |a pregnancy | |
| 650 | 4 | |a steroid | |
| 650 | 7 | |a ADAMTS13 Protein |2 NLM | |
| 650 | 7 | |a EC 3.4.24.87 |2 NLM | |
| 650 | 7 | |a Steroids |2 NLM | |
| 700 | 1 | |a Tanimura, Kenji |e verfasserin |4 aut | |
| 700 | 1 | |a Sasagawa, Yuki |e verfasserin |4 aut | |
| 700 | 1 | |a Yamada, Hirotaka |e verfasserin |4 aut | |
| 700 | 1 | |a Katayama, Yoshio |e verfasserin |4 aut | |
| 700 | 1 | |a Matsumoto, Masanori |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of obstetrics and gynaecology research |d 1997 |g 49(2023), 12 vom: 18. Dez., Seite 2969-2974 |w (DE-627)NLM085989509 |x 1447-0756 |7 nnns |
| 773 | 1 | 8 | |g volume:49 |g year:2023 |g number:12 |g day:18 |g month:12 |g pages:2969-2974 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1111/jog.15793 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 49 |j 2023 |e 12 |b 18 |c 12 |h 2969-2974 | ||