A territory-wide opportunistic, hospital-based HCV screening in the general population from northern Italy : The 1969-1989 birth-cohort
© 2023 The Authors. Liver International published by John Wiley & Sons Ltd..
BACKGROUND AND AIM: The World Health Organization (WHO) goal of Hepatitis C Virus (HCV) elimination by 2030 rose awareness about the need of screening plans, worldwide. In Italy, graduated screening starting from people born in 1969-1989 might be the most-effective strategy. We performed an opportunistic HCV screening study in the general population attending health facilities in Lombardy region, Northern Italy.
METHODS: This is a prospective, multicenter, territory-wide, opportunistic study supported by the Regional Government of Lombardy, Italy. Between June 2022 and December 2022, all subjects born in 1969-1989, hospitalized or accessing blood collection centres were offered anti-HCV and HCV-RNA tests. Patients with known anti-HCV positivity and/or previous anti-HCV treatment were excluded. Demographic features were uploaded into a regional web-based platform.
RESULTS: In total, 120 193 individuals were screened in 75 centres. Mean age was 44 (±6) years, 65.2% were females, 83.7% were tested at blood collection centres. Anti-HCV tested positive in 604 (0.50%) subjects: mean age 47 (±5), 51.1% females. HCV seroprevalence was higher in males (p < 0.00001), elderly (p < 0.00001) and in- vs. outpatients (p = 0.0009). HCV-RNA was detectable in 125 out of 441 (28.3%) anti-HCV positive subjects. Actively infected patients were 46 (±6) years old, mainly males (56.8%). The overall prevalence of active HCV infection was 0.10%, higher in elderly (p = 0.0003) and in in-patients (p = 0.0007). Among 93 HCV-RNA positive patients, the median age was 48 years, 58% males, 62% Italian born, median HCV-RNA levels were 6,1 log IU/mL, liver stiffness measurement (LSM) values 5.5 (3.1-29.9) kPa and ALT levels 48 U/L.
CONCLUSIONS: The prevalence of active HCV infection in the 1969-1989 population attending health facilities in Lombardy was low. Most viremic patients were Italian-born, with mild liver disease but high-HCV-RNA levels. Due to the higher prevalence in the elderly, the extension of such opportunistic screening programs to lower birth cohorts would be warranted.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
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| Enthalten in: |
Liver international : official journal of the International Association for the Study of the Liver - 43(2023), 12 vom: 04. Dez., Seite 2645-2656 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
D'Ambrosio, Roberta [VerfasserIn] |
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| Links: |
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| Themen: |
1969-1989 |
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| Anmerkungen: |
Date Completed 29.11.2023 Date Revised 26.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/liv.15727 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a D'Ambrosio, Roberta |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A territory-wide opportunistic, hospital-based HCV screening in the general population from northern Italy |b The 1969-1989 birth-cohort |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 29.11.2023 | ||
| 500 | |a Date Revised 26.01.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 The Authors. Liver International published by John Wiley & Sons Ltd. | ||
| 520 | |a BACKGROUND AND AIM: The World Health Organization (WHO) goal of Hepatitis C Virus (HCV) elimination by 2030 rose awareness about the need of screening plans, worldwide. In Italy, graduated screening starting from people born in 1969-1989 might be the most-effective strategy. We performed an opportunistic HCV screening study in the general population attending health facilities in Lombardy region, Northern Italy | ||
| 520 | |a METHODS: This is a prospective, multicenter, territory-wide, opportunistic study supported by the Regional Government of Lombardy, Italy. Between June 2022 and December 2022, all subjects born in 1969-1989, hospitalized or accessing blood collection centres were offered anti-HCV and HCV-RNA tests. Patients with known anti-HCV positivity and/or previous anti-HCV treatment were excluded. Demographic features were uploaded into a regional web-based platform | ||
| 520 | |a RESULTS: In total, 120 193 individuals were screened in 75 centres. Mean age was 44 (±6) years, 65.2% were females, 83.7% were tested at blood collection centres. Anti-HCV tested positive in 604 (0.50%) subjects: mean age 47 (±5), 51.1% females. HCV seroprevalence was higher in males (p < 0.00001), elderly (p < 0.00001) and in- vs. outpatients (p = 0.0009). HCV-RNA was detectable in 125 out of 441 (28.3%) anti-HCV positive subjects. Actively infected patients were 46 (±6) years old, mainly males (56.8%). The overall prevalence of active HCV infection was 0.10%, higher in elderly (p = 0.0003) and in in-patients (p = 0.0007). Among 93 HCV-RNA positive patients, the median age was 48 years, 58% males, 62% Italian born, median HCV-RNA levels were 6,1 log IU/mL, liver stiffness measurement (LSM) values 5.5 (3.1-29.9) kPa and ALT levels 48 U/L | ||
| 520 | |a CONCLUSIONS: The prevalence of active HCV infection in the 1969-1989 population attending health facilities in Lombardy was low. Most viremic patients were Italian-born, with mild liver disease but high-HCV-RNA levels. Due to the higher prevalence in the elderly, the extension of such opportunistic screening programs to lower birth cohorts would be warranted | ||
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a 1969-1989 | |
| 650 | 4 | |a WHO | |
| 650 | 4 | |a birth cohorts | |
| 650 | 4 | |a hepatitis C virus | |
| 650 | 4 | |a screening | |
| 650 | 7 | |a RNA, Viral |2 NLM | |
| 650 | 7 | |a Hepatitis C Antibodies |2 NLM | |
| 700 | 1 | |a Piccinelli, Sara |e verfasserin |4 aut | |
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| 700 | 1 | |a Spinetti, Angiola |e verfasserin |4 aut | |
| 700 | 1 | |a Puoti, Massimo |e verfasserin |4 aut | |
| 700 | 1 | |a Fagiuoli, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Magni, Carlo Federico |e verfasserin |4 aut | |
| 700 | 1 | |a Vavassori, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Sacchi, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Castaldi, Silvana |e verfasserin |4 aut | |
| 700 | 1 | |a Bombardieri, Giulia |e verfasserin |4 aut | |
| 700 | 1 | |a Farina, Claudio |e verfasserin |4 aut | |
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| 700 | 1 | |a Amorosi, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Corradin, Matteo |e verfasserin |4 aut | |
| 700 | 1 | |a Cereda, Danilo |e verfasserin |4 aut | |
| 700 | 1 | |a Lampertico, Pietro |e verfasserin |4 aut | |
| 700 | 0 | |a Regional HCV Working Group |e verfasserin |4 aut | |
| 700 | 1 | |a Aghemo, Alessio Michele |e investigator |4 oth | |
| 700 | 1 | |a Agnoletti, Laura |e investigator |4 oth | |
| 700 | 1 | |a Aiello, Paola |e investigator |4 oth | |
| 700 | 1 | |a Andreoli, Francesca |e investigator |4 oth | |
| 700 | 1 | |a Arena, Ilaria |e investigator |4 oth | |
| 700 | 1 | |a Arghittu, Milena |e investigator |4 oth | |
| 700 | 1 | |a Arosio, Marco |e investigator |4 oth | |
| 700 | 1 | |a Basilico, Cristina |e investigator |4 oth | |
| 700 | 1 | |a Barca, Roberta |e investigator |4 oth | |
| 700 | 1 | |a Belleri, Ezio |e investigator |4 oth | |
| 700 | 1 | |a Bertoli, Maria Teresa |e investigator |4 oth | |
| 700 | 1 | |a Bhoori, Sherrie |e investigator |4 oth | |
| 700 | 1 | |a Bianchi, Francesca |e investigator |4 oth | |
| 700 | 1 | |a Bonetti, Cristina |e investigator |4 oth | |
| 700 | 1 | |a Bonfanti, Paolo |e investigator |4 oth | |
| 700 | 1 | |a Alquati, Anna Bonisoli |e investigator |4 oth | |
| 700 | 1 | |a Boselli, Luisa |e investigator |4 oth | |
| 700 | 1 | |a Brocchieri, Alessandra |e investigator |4 oth | |
| 700 | 1 | |a Cacitti, Stefano |e investigator |4 oth | |
| 700 | 1 | |a Campostrini, Lorella |e investigator |4 oth | |
| 700 | 1 | |a Carderi, Isabella |e investigator |4 oth | |
| 700 | 1 | |a Casari, Salvatore |e investigator |4 oth | |
| 700 | 1 | |a Castellani, Lucia |e investigator |4 oth | |
| 700 | 1 | |a Castelli, Francesco |e investigator |4 oth | |
| 700 | 1 | |a Ceriotti, Ferruccio |e investigator |4 oth | |
| 700 | 1 | |a Cesana, Elisabetta |e investigator |4 oth | |
| 700 | 1 | |a Ciaccio, Antonio |e investigator |4 oth | |
| 700 | 1 | |a Colciago, Massimo |e investigator |4 oth | |
| 700 | 1 | |a Colombo, Ilaria |e investigator |4 oth | |
| 700 | 1 | |a Colombo, Silvia |e investigator |4 oth | |
| 700 | 1 | |a Corradi, Chiara |e investigator |4 oth | |
| 700 | 1 | |a Crisetig, Marina |e investigator |4 oth | |
| 700 | 1 | |a Crottigini, Lucia |e investigator |4 oth | |
| 700 | 1 | |a Cuntrò, Marina |e investigator |4 oth | |
| 700 | 1 | |a D'Aloia, Alfonso Guido |e investigator |4 oth | |
| 700 | 1 | |a Zoppo, Sarah Dal |e investigator |4 oth | |
| 700 | 1 | |a Carbonare, Simona Dalle |e investigator |4 oth | |
| 700 | 1 | |a De Paschale, Massimo |e investigator |4 oth | |
| 700 | 1 | |a Di Caterina, Davide |e investigator |4 oth | |
| 700 | 1 | |a Di Fazio, Ignazio |e investigator |4 oth | |
| 700 | 1 | |a Di Marco, Maria |e investigator |4 oth | |
| 700 | 1 | |a Domeniconi, Giulia |e investigator |4 oth | |
| 700 | 1 | |a Domenighini, Serena Giulia |e investigator |4 oth | |
| 700 | 1 | |a Donadini, Annalisa |e investigator |4 oth | |
| 700 | 1 | |a Edo, Sergio |e investigator |4 oth | |
| 700 | 1 | |a Elba, Enrico |e investigator |4 oth | |
| 700 | 1 | |a Fasano, Maria Antonietta |e investigator |4 oth | |
| 700 | 1 | |a Ferrante, Angela |e investigator |4 oth | |
| 700 | 1 | |a Fonte, Luigi |e investigator |4 oth | |
| 700 | 1 | |a Gargarella, Annalisa |e investigator |4 oth | |
| 700 | 1 | |a Gasparri, Serena |e investigator |4 oth | |
| 700 | 1 | |a Gennati, Giorgio |e investigator |4 oth | |
| 700 | 1 | |a Ghioldi, Davide |e investigator |4 oth | |
| 700 | 1 | |a Giglio, Omar |e investigator |4 oth | |
| 700 | 1 | |a Giuliani, Giuseppe |e investigator |4 oth | |
| 700 | 1 | |a Graffeo, Massimo |e investigator |4 oth | |
| 700 | 1 | |a Grimaldi, Chiara |e investigator |4 oth | |
| 700 | 1 | |a Grossi, Paolo |e investigator |4 oth | |
| 700 | 1 | |a Guarneri, Davide |e investigator |4 oth | |
| 700 | 1 | |a Hasson, Hamid |e investigator |4 oth | |
| 700 | 1 | |a Ilardo, Antonina |e investigator |4 oth | |
| 700 | 1 | |a Kanso, Foaud |e investigator |4 oth | |
| 700 | 1 | |a Leanza, Annalisa |e investigator |4 oth | |
| 700 | 1 | |a Liani, Cecilia |e investigator |4 oth | |
| 700 | 1 | |a Magnani, Luigi |e investigator |4 oth | |
| 700 | 1 | |a Maiocchi, Maria Angela |e investigator |4 oth | |
| 700 | 1 | |a Marazza, Giovanni |e investigator |4 oth | |
| 700 | 1 | |a Marin, Maria Grazia |e investigator |4 oth | |
| 700 | 1 | |a Marrocu, Chiara |e investigator |4 oth | |
| 700 | 1 | |a Martinelli, Livia Antonietta |e investigator |4 oth | |
| 700 | 1 | |a Mazzoni, Francesco |e investigator |4 oth | |
| 700 | 1 | |a Mazzoni, Sergio |e investigator |4 oth | |
| 700 | 1 | |a Meloni, Alessandro |e investigator |4 oth | |
| 700 | 1 | |a Mendeni, Monia |e investigator |4 oth | |
| 700 | 1 | |a Menozzi, Fernanda |e investigator |4 oth | |
| 700 | 1 | |a Menzaghi, Barbara |e investigator |4 oth | |
| 700 | 1 | |a Milini, Mattia |e investigator |4 oth | |
| 700 | 1 | |a Nobili, Alessandra |e investigator |4 oth | |
| 700 | 1 | |a Odelli, Stefano |e investigator |4 oth | |
| 700 | 1 | |a Omazzi, Barbara |e investigator |4 oth | |
| 700 | 1 | |a Pan, Angelo |e investigator |4 oth | |
| 700 | 1 | |a Pastori, Stefano |e investigator |4 oth | |
| 700 | 1 | |a Pasulo, Luisa |e investigator |4 oth | |
| 700 | 1 | |a Pavesi, Loredana |e investigator |4 oth | |
| 700 | 1 | |a Pavia, Greta |e investigator |4 oth | |
| 700 | 1 | |a Peros, Emmanouil |e investigator |4 oth | |
| 700 | 1 | |a Perotti, Pietro |e investigator |4 oth | |
| 700 | 1 | |a Piotti, Ileana |e investigator |4 oth | |
| 700 | 1 | |a Piva, Elisa |e investigator |4 oth | |
| 700 | 1 | |a Polo, Silva |e investigator |4 oth | |
| 700 | 1 | |a Polvara, Donatella |e investigator |4 oth | |
| 700 | 1 | |a Popovic, Aleksandra |e investigator |4 oth | |
| 700 | 1 | |a Pozzoni, Pietro |e investigator |4 oth | |
| 700 | 1 | |a Pusterla, Luigi |e investigator |4 oth | |
| 700 | 1 | |a Ranieri, Roberto |e investigator |4 oth | |
| 700 | 1 | |a Regazzetti, Angelo |e investigator |4 oth | |
| 700 | 1 | |a Riboli, Simona |e investigator |4 oth | |
| 700 | 1 | |a Riglietta, Marco |e investigator |4 oth | |
| 700 | 1 | |a Rinaldi, Lucia |e investigator |4 oth | |
| 700 | 1 | |a Rinaldi, Oliviero |e investigator |4 oth | |
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