Emerging Applications of Hydroxypropyl Methylcellulose Acetate Succinate : Different Aspects in Drug Delivery and Its Commercial Potential
© 2023. The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists..
Hydroxypropyl methylcellulose acetate succinate (HPMCAS) has multi-disciplinary applications spanning across the development of drug delivery systems, in 3D printing, and in tissue engineering, etc. HPMCAS helps in maintaining the drug in a super-saturated condition by inhibiting its precipitation, thereby increasing the rate and extent of dissolution in the aqueous media. HPMCAS has several distinctive characteristics, such as being amphiphilic in nature, having an ionization pH, and a succinyl and acetyl substitution ratio, all of which are beneficial while developing formulations. This review provides insights regarding the various types of formulations being developed using HPMCAS, including amorphous solid dispersion (ASD), amorphous nanoparticles, dry coating, and 3D printing, along with their applicability in drug delivery and biomedical fields. Furthermore, HPMCAS, compared with other carbohydrate polymers, shows several benefits in drug delivery, including proficiency in imparting stable ASD with a high dissolution rate, being easily processable, and enhancing bioavailability. The various commercially available formulations, regulatory considerations, and key patents containing the HPMCAS have been discussed in this review.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
|---|---|
| Enthalten in: |
AAPS PharmSciTech - 24(2023), 7 vom: 15. Sept., Seite 188 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Choudhari, Manisha [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 18.09.2023 Date Revised 24.10.2023 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1208/s12249-023-02645-1 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM362121443 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM362121443 | ||
| 003 | DE-627 | ||
| 005 | 20231226090600.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1208/s12249-023-02645-1 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1207.xml |
| 035 | |a (DE-627)NLM362121443 | ||
| 035 | |a (NLM)37715004 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Choudhari, Manisha |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Emerging Applications of Hydroxypropyl Methylcellulose Acetate Succinate |b Different Aspects in Drug Delivery and Its Commercial Potential |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 18.09.2023 | ||
| 500 | |a Date Revised 24.10.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists. | ||
| 520 | |a Hydroxypropyl methylcellulose acetate succinate (HPMCAS) has multi-disciplinary applications spanning across the development of drug delivery systems, in 3D printing, and in tissue engineering, etc. HPMCAS helps in maintaining the drug in a super-saturated condition by inhibiting its precipitation, thereby increasing the rate and extent of dissolution in the aqueous media. HPMCAS has several distinctive characteristics, such as being amphiphilic in nature, having an ionization pH, and a succinyl and acetyl substitution ratio, all of which are beneficial while developing formulations. This review provides insights regarding the various types of formulations being developed using HPMCAS, including amorphous solid dispersion (ASD), amorphous nanoparticles, dry coating, and 3D printing, along with their applicability in drug delivery and biomedical fields. Furthermore, HPMCAS, compared with other carbohydrate polymers, shows several benefits in drug delivery, including proficiency in imparting stable ASD with a high dissolution rate, being easily processable, and enhancing bioavailability. The various commercially available formulations, regulatory considerations, and key patents containing the HPMCAS have been discussed in this review | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a HPMCAS | |
| 650 | 4 | |a amorphous solid dispersion | |
| 650 | 4 | |a cellulose-based derivatives | |
| 650 | 4 | |a pH-responsive | |
| 650 | 4 | |a solubility enhancement | |
| 650 | 7 | |a hydroxypropylmethylcellulose acetate succinate |2 NLM | |
| 650 | 7 | |a 71138-97-1 |2 NLM | |
| 650 | 7 | |a Methylcellulose |2 NLM | |
| 650 | 7 | |a 9004-67-5 |2 NLM | |
| 700 | 1 | |a Damle, Shantanu |e verfasserin |4 aut | |
| 700 | 1 | |a Saha, Ranendra Narayan |e verfasserin |4 aut | |
| 700 | 1 | |a Dubey, Sunil Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Singhvi, Gautam |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t AAPS PharmSciTech |d 2000 |g 24(2023), 7 vom: 15. Sept., Seite 188 |w (DE-627)NLM126699429 |x 1530-9932 |7 nnns |
| 773 | 1 | 8 | |g volume:24 |g year:2023 |g number:7 |g day:15 |g month:09 |g pages:188 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1208/s12249-023-02645-1 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 24 |j 2023 |e 7 |b 15 |c 09 |h 188 | ||