The most recent compilation of reactions of enaminone derivatives with various amine derivatives to generate biologically active compounds
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
Heterocyclic derivatives serve as the fundamental components of both natural and synthetic drugs. Enaminones play a crucial role as foundational units in the synthesis of numerous bioactive heterocyclic compounds, including pyrazoles, pyridines, oxazoles, isoxazoles, as well as fused heterocyclic structures like indoles, carbazoles, quinolines, acridines, and phenanthridines. These diverse heterocyclic rings are well-known for their various therapeutic activities, encompassing anticancer, anti-inflammatory, antimicrobial, antidepressant, and antiviral properties. By reacting with nitrogen-based nucleophiles, enaminones can generate bioactive azoles, azines, and their fused systems. This comprehensive review article focuses on the recent advancements in enaminone reactions with (a) nitrogen-based nucleophiles, such as aliphatic amines, derivatives of aniline, heterocyclic amines, hydroxylamine, hydrazine derivatives, guanidine derivatives, urea, and thiourea derivatives, and (b) nitrogen-based electrophiles, such as diazonium salts. These reactions have led to the synthesis of a wide range of bioactive fused heterocyclic compounds from 2010 to the end of 2022.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2023 |
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| Enthalten in: |
Mini reviews in medicinal chemistry - (2023) vom: 13. Sept. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Farghaly, Thoraya A [VerfasserIn] |
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| Links: |
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| Themen: |
Aminobenzimidazoles |
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| Anmerkungen: |
Date Revised 15.09.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.2174/1389557523666230913164038 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM362082650 |
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| 500 | |a Date Revised 15.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a Heterocyclic derivatives serve as the fundamental components of both natural and synthetic drugs. Enaminones play a crucial role as foundational units in the synthesis of numerous bioactive heterocyclic compounds, including pyrazoles, pyridines, oxazoles, isoxazoles, as well as fused heterocyclic structures like indoles, carbazoles, quinolines, acridines, and phenanthridines. These diverse heterocyclic rings are well-known for their various therapeutic activities, encompassing anticancer, anti-inflammatory, antimicrobial, antidepressant, and antiviral properties. By reacting with nitrogen-based nucleophiles, enaminones can generate bioactive azoles, azines, and their fused systems. This comprehensive review article focuses on the recent advancements in enaminone reactions with (a) nitrogen-based nucleophiles, such as aliphatic amines, derivatives of aniline, heterocyclic amines, hydroxylamine, hydrazine derivatives, guanidine derivatives, urea, and thiourea derivatives, and (b) nitrogen-based electrophiles, such as diazonium salts. These reactions have led to the synthesis of a wide range of bioactive fused heterocyclic compounds from 2010 to the end of 2022 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Enaminones | |
| 650 | 4 | |a aminobenzimidazoles | |
| 650 | 4 | |a aminopyrazoles | |
| 650 | 4 | |a aromatic amines | |
| 650 | 4 | |a heteroamines | |
| 700 | 1 | |a Alosaimy, Amal M |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Qurashi, Nadia T |e verfasserin |4 aut | |
| 700 | 1 | |a Masaret, Ghada S |e verfasserin |4 aut | |
| 700 | 1 | |a Abdulwahab, Hanan Gaber |e verfasserin |4 aut | |
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