Research progress on tamoxifen and its analogs associated with nuclear receptors
Tamoxifen, a triphenylethylene-based selective estrogen-receptor modulator, is a landmark drug for the treatment of breast cancer and is also used for treating liver cancer and osteoporosis. Structural studies of tamoxifen have led to the synthesis of more than 20 novel tamoxifen analogs as receptor modulators, including 16 ERα modulators 2-17, an ERRβ inverse agonist 19 and six ERRγ inverse agonists 20-25. This paper summarizes the research progress and structure-activity relationships of tamoxifen analogs modulating these three nuclear receptors reported in the literature, and introduces the relationship between these three nuclear receptor-mediated diseases and tamoxifen analogs to guide the research of novel tamoxifen analogs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Future medicinal chemistry - 15(2023), 15 vom: 24. Aug., Seite 1427-1442 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dong, Ning [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 11.10.2023 Date Revised 12.10.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.4155/fmc-2023-0092 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM362034737 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Tamoxifen, a triphenylethylene-based selective estrogen-receptor modulator, is a landmark drug for the treatment of breast cancer and is also used for treating liver cancer and osteoporosis. Structural studies of tamoxifen have led to the synthesis of more than 20 novel tamoxifen analogs as receptor modulators, including 16 ERα modulators 2-17, an ERRβ inverse agonist 19 and six ERRγ inverse agonists 20-25. This paper summarizes the research progress and structure-activity relationships of tamoxifen analogs modulating these three nuclear receptors reported in the literature, and introduces the relationship between these three nuclear receptor-mediated diseases and tamoxifen analogs to guide the research of novel tamoxifen analogs | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
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| 650 | 4 | |a ERRγ inverse agonists | |
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| 650 | 4 | |a SAR | |
| 650 | 4 | |a Tamoxifen and its analogs | |
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| 650 | 7 | |a Estrogen Receptor alpha |2 NLM | |
| 650 | 7 | |a Receptors, Estrogen |2 NLM | |
| 700 | 1 | |a Du, Yongli |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Haibin |e verfasserin |4 aut | |
| 700 | 1 | |a Lv, Huiting |e verfasserin |4 aut | |
| 700 | 1 | |a Yan, Zhijia |e verfasserin |4 aut | |
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