Clinical and epidemiological factors causing longer SARS-CoV 2 viral shedding : the results from the CoviCamp cohort
© 2023. The Author(s)..
INTRODUCTION: The aim of this study was to investigate how long hospitalized patients stayed positive to the nasopharyngeal swab, and what demographic and clinical factors influence the time-to-negative swab.
METHODS: We enrolled in a multicenter, observational, retrospective study involving 17 COVID-19 units in eight cities of the Campania, southern Italy all patients hospitalized from March 2020 to May 2021 diagnosed with Severe Acute Respiratory Distress Syndrome-Coronavirus-2 (SARS-CoV-2) infection for whom time-to-negative swab was available.
RESULTS: 963 patients were enrolled. We defined three groups considering time-to-negative swab: the first including patients with time-to-negative swab before the 26th day, the second including patients with time-to-negative swab from day 26 to day 39, and the third including patients with time-to-negative swab > 39 days. 721 (74.9%) patients belonged to the first group, 194 (20.1%) to the second, and 52 (5.4%) belonged to the third group. Belonging to group 2 and 3 seemed to be influenced by age (p value < 0.001), Charlson comorbidity index (p = 0.009), arterial hypertension (p = 0.02), cardiovascular disease (p = 0.017), or chronic kidney disease (CKD) (p = 0.001). The multivariable analysis confers a leading role to CKD, with an odds ratio of 2.3 as factor influencing belonging to the groups showing a longer time-to-negative swab. Patients with CKD and diabetes were more frequently in the third group.
DISCUSSION: Our analysis showed that CKD is a factor related to longer time-to-negative swab, probably because of immunosuppression related to this condition.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:52 |
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| Enthalten in: |
Infection - 52(2024), 2 vom: 01. März, Seite 439-446 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Grimaldi, Pierantonio [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 21.03.2024 Date Revised 23.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s15010-023-02095-8 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Grimaldi, Pierantonio |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical and epidemiological factors causing longer SARS-CoV 2 viral shedding |b the results from the CoviCamp cohort |
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| 500 | |a Date Revised 23.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a INTRODUCTION: The aim of this study was to investigate how long hospitalized patients stayed positive to the nasopharyngeal swab, and what demographic and clinical factors influence the time-to-negative swab | ||
| 520 | |a METHODS: We enrolled in a multicenter, observational, retrospective study involving 17 COVID-19 units in eight cities of the Campania, southern Italy all patients hospitalized from March 2020 to May 2021 diagnosed with Severe Acute Respiratory Distress Syndrome-Coronavirus-2 (SARS-CoV-2) infection for whom time-to-negative swab was available | ||
| 520 | |a RESULTS: 963 patients were enrolled. We defined three groups considering time-to-negative swab: the first including patients with time-to-negative swab before the 26th day, the second including patients with time-to-negative swab from day 26 to day 39, and the third including patients with time-to-negative swab > 39 days. 721 (74.9%) patients belonged to the first group, 194 (20.1%) to the second, and 52 (5.4%) belonged to the third group. Belonging to group 2 and 3 seemed to be influenced by age (p value < 0.001), Charlson comorbidity index (p = 0.009), arterial hypertension (p = 0.02), cardiovascular disease (p = 0.017), or chronic kidney disease (CKD) (p = 0.001). The multivariable analysis confers a leading role to CKD, with an odds ratio of 2.3 as factor influencing belonging to the groups showing a longer time-to-negative swab. Patients with CKD and diabetes were more frequently in the third group | ||
| 520 | |a DISCUSSION: Our analysis showed that CKD is a factor related to longer time-to-negative swab, probably because of immunosuppression related to this condition | ||
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a RT-PCR | |
| 650 | 4 | |a SARS-CoV-2 infection | |
| 650 | 4 | |a Time-to-negative swab | |
| 650 | 4 | |a Viral shedding | |
| 700 | 1 | |a Russo, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Pisaturo, Mariantonietta |e verfasserin |4 aut | |
| 700 | 1 | |a Maggi, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Allegorico, Enrico |e verfasserin |4 aut | |
| 700 | 1 | |a Gentile, Ivan |e verfasserin |4 aut | |
| 700 | 1 | |a Sangiovanni, Vincenzo |e verfasserin |4 aut | |
| 700 | 1 | |a Rossomando, Annamaria |e verfasserin |4 aut | |
| 700 | 1 | |a Pacilio, Rossella |e verfasserin |4 aut | |
| 700 | 1 | |a Calabria, Giosuele |e verfasserin |4 aut | |
| 700 | 1 | |a Pisapia, Raffaella |e verfasserin |4 aut | |
| 700 | 1 | |a Carriero, Canio |e verfasserin |4 aut | |
| 700 | 1 | |a Masullo, Alfonso |e verfasserin |4 aut | |
| 700 | 1 | |a Manzillo, Elio |e verfasserin |4 aut | |
| 700 | 1 | |a Russo, Grazia |e verfasserin |4 aut | |
| 700 | 1 | |a Parrella, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Dell'Aquila, Giuseppina |e verfasserin |4 aut | |
| 700 | 1 | |a Gambardella, Michele |e verfasserin |4 aut | |
| 700 | 1 | |a Ponticiello, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Onorato, Lorenzo |e verfasserin |4 aut | |
| 700 | 1 | |a Coppola, Nicola |e verfasserin |4 aut | |
| 700 | 0 | |a CoviCam group |e verfasserin |4 aut | |
| 700 | 1 | |a Monari, Caterina |e investigator |4 oth | |
| 700 | 1 | |a Sagnelli, Caterina |e investigator |4 oth | |
| 700 | 1 | |a Numis, Fabio Giuliano |e investigator |4 oth | |
| 700 | 1 | |a Rescigno, Carolina |e investigator |4 oth | |
| 700 | 1 | |a Megna, Angelo Salomone |e investigator |4 oth | |
| 700 | 1 | |a Esposito, Vincenzo |e investigator |4 oth | |
| 700 | 1 | |a Punzi, Rodolfo |e investigator |4 oth | |
| 700 | 1 | |a Fusco, Francesco Maria |e investigator |4 oth | |
| 700 | 1 | |a Porta, Giovanni |e investigator |4 oth | |
| 700 | 1 | |a Macera, Margherita |e investigator |4 oth | |
| 700 | 1 | |a Calò, Federica |e investigator |4 oth | |
| 700 | 1 | |a Cascone, Angela |e investigator |4 oth | |
| 700 | 1 | |a Stornaiuolo, Gianfranca |e investigator |4 oth | |
| 700 | 1 | |a Stanzione, Maria |e investigator |4 oth | |
| 700 | 1 | |a Medusa, Paola |e investigator |4 oth | |
| 700 | 1 | |a Nicola, Carro |e investigator |4 oth | |
| 700 | 1 | |a Dell'aquila, Andrea |e investigator |4 oth | |
| 700 | 1 | |a Imbriani, Simona |e investigator |4 oth | |
| 700 | 1 | |a Carmen, Ricozzi |e investigator |4 oth | |
| 700 | 1 | |a Gjeloshi, Klodian |e investigator |4 oth | |
| 700 | 1 | |a Astorri, Roberta |e investigator |4 oth | |
| 700 | 1 | |a Rossomando, Anna Maria |e investigator |4 oth | |
| 700 | 1 | |a Di Lorenzo, Mariana |e investigator |4 oth | |
| 700 | 1 | |a Bosso, Giorgio |e investigator |4 oth | |
| 700 | 1 | |a Serra, Claudia |e investigator |4 oth | |
| 700 | 1 | |a Vicario, Ferdinando Dello |e investigator |4 oth | |
| 700 | 1 | |a Minerva, Valentina |e investigator |4 oth | |
| 700 | 1 | |a De Angelis, Giulia |e investigator |4 oth | |
| 700 | 1 | |a De Pascalis, Stefania |e investigator |4 oth | |
| 700 | 1 | |a Martini, Salvatore |e investigator |4 oth | |
| 700 | 1 | |a Di Caprio, Giovanni |e investigator |4 oth | |
| 700 | 1 | |a Masiello, Addolorata |e investigator |4 oth | |
| 700 | 1 | |a Di Costanzo, Domenica |e investigator |4 oth | |
| 700 | 1 | |a Mazza, Mariano |e investigator |4 oth | |
| 700 | 1 | |a Bianco, Vincenzo |e investigator |4 oth | |
| 700 | 1 | |a Gentile, Valeria |e investigator |4 oth | |
| 700 | 1 | |a Buonomo, Antonio Riccardo |e investigator |4 oth | |
| 700 | 1 | |a Pinchera, Biagio |e investigator |4 oth | |
| 700 | 1 | |a Scotto, Riccardo |e investigator |4 oth | |
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