Phenolic composition and antioxidant capacity of betel inflorescence extract in a simulated oral environment
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved..
The addition of betel inflorescence (BI) and slaked lime (calcium hydroxide) to betel quid (BQ) formulation may be detrimental to human health. Here, we assessed BI extracts prepared using artificial saliva or aqueous solution with or without adding slaked lime to mimic the release of phytochemicals from BI in the oral cavity. The extracts were also profiled by HPLC-DAD-ESI-QTOF-MS/MS to understand the quality and quantity of phytochemicals released. The results indicate that slaked lime facilitates the extraction of phenolics, likely due to a high pH. In a simulated oral environment with artificial saliva, the addition of slaked lime promotes the release of safrole, a well-known carcinogen. Dominant phytochemicals detected also include eugenol, acetyl eugenol and methyl eugenol, and only a fraction of these compounds is released in the simulated oral environment. This study reveals that environmental conditions can considerably affect the extraction of phytochemicals and triggers further investigation on how chewing practices may influence the release and activity of carcinogens.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 2023 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:434 |
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| Enthalten in: |
Food chemistry - 434(2023) vom: 15. Feb., Seite 137411 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Pangzhen [VerfasserIn] |
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| Links: |
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| Themen: |
Antioxidant activity |
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| Anmerkungen: |
Date Revised 11.10.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.foodchem.2023.137411 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM362010722 |
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| 520 | |a Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a The addition of betel inflorescence (BI) and slaked lime (calcium hydroxide) to betel quid (BQ) formulation may be detrimental to human health. Here, we assessed BI extracts prepared using artificial saliva or aqueous solution with or without adding slaked lime to mimic the release of phytochemicals from BI in the oral cavity. The extracts were also profiled by HPLC-DAD-ESI-QTOF-MS/MS to understand the quality and quantity of phytochemicals released. The results indicate that slaked lime facilitates the extraction of phenolics, likely due to a high pH. In a simulated oral environment with artificial saliva, the addition of slaked lime promotes the release of safrole, a well-known carcinogen. Dominant phytochemicals detected also include eugenol, acetyl eugenol and methyl eugenol, and only a fraction of these compounds is released in the simulated oral environment. This study reveals that environmental conditions can considerably affect the extraction of phytochemicals and triggers further investigation on how chewing practices may influence the release and activity of carcinogens | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Antioxidant activity | |
| 650 | 4 | |a Artificial saliva | |
| 650 | 4 | |a Betel inflorescence | |
| 650 | 4 | |a Carcinogen | |
| 650 | 4 | |a Phenolic compounds | |
| 650 | 4 | |a Safrole | |
| 700 | 1 | |a Reza, Ahmad |e verfasserin |4 aut | |
| 700 | 1 | |a Ng, Emily |e verfasserin |4 aut | |
| 700 | 1 | |a Nguyen, Kimtrang |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Sheng |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Zijian |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yipeng |e verfasserin |4 aut | |
| 700 | 1 | |a Cirillo, Nicola |e verfasserin |4 aut | |
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