High-dose IV magnesium in mesothelioma patients receiving surgery with hyperthermic intraoperative cisplatin : Pilot studies and design of a phase II randomized clinical trial
© 2023 Wiley Periodicals LLC..
INTRODUCTION: Hyperthermic intraoperative cisplatin (HIOC) is associated with acute kidney injury (AKI). Administration of high-dose magnesium attenuates cisplatin-induced AKI (CP-AKI) in animal models but has not been rigorously examined in humans.
METHODS: We tested the feasibility and safety of different doses of magnesium in mesothelioma patients receiving HIOC. In Pilot Study 1, we administered a 36-h continuous infusion of magnesium at 0.5 g/h, targeting serum magnesium levels between 3 and 4.8 mg/dL. In Pilot Study 2A, we administered a 6 g bolus followed by an infusion starting at 2 g/h, titrated to achieve levels between 4 and 6 mg/dL. We eliminated the bolus in Pilot Study 2B.
RESULTS: In Pilot Study 1, all five patients enrolled completed the study; however, median postoperative Mg levels were only 2.4 mg/dL. In Pilot Study 2A, two of four patients (50%) were withdrawn due to bradycardia during the bolus. In Pilot Study 2B, two patients completed the study whereas two developed postoperative bradycardia attributed to the magnesium.
CONCLUSIONS: A 0.5 g/h infusion for 36 h did not achieve therapeutic magnesium levels, while an infusion at 2 g/h was associated with bradycardia. These studies informed the design of a randomized clinical trial testing whether intravenously Mg attenuates HIOC-associated AKI.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:128 |
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Enthalten in: |
Journal of surgical oncology - 128(2023), 7 vom: 19. Dez., Seite 1141-1149 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Gupta, Shruti [VerfasserIn] |
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Links: |
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Themen: |
Acute kidney injury |
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Anmerkungen: |
Date Completed 26.10.2023 Date Revised 10.02.2024 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1002/jso.27412 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM361997310 |
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520 | |a INTRODUCTION: Hyperthermic intraoperative cisplatin (HIOC) is associated with acute kidney injury (AKI). Administration of high-dose magnesium attenuates cisplatin-induced AKI (CP-AKI) in animal models but has not been rigorously examined in humans | ||
520 | |a METHODS: We tested the feasibility and safety of different doses of magnesium in mesothelioma patients receiving HIOC. In Pilot Study 1, we administered a 36-h continuous infusion of magnesium at 0.5 g/h, targeting serum magnesium levels between 3 and 4.8 mg/dL. In Pilot Study 2A, we administered a 6 g bolus followed by an infusion starting at 2 g/h, titrated to achieve levels between 4 and 6 mg/dL. We eliminated the bolus in Pilot Study 2B | ||
520 | |a RESULTS: In Pilot Study 1, all five patients enrolled completed the study; however, median postoperative Mg levels were only 2.4 mg/dL. In Pilot Study 2A, two of four patients (50%) were withdrawn due to bradycardia during the bolus. In Pilot Study 2B, two patients completed the study whereas two developed postoperative bradycardia attributed to the magnesium | ||
520 | |a CONCLUSIONS: A 0.5 g/h infusion for 36 h did not achieve therapeutic magnesium levels, while an infusion at 2 g/h was associated with bradycardia. These studies informed the design of a randomized clinical trial testing whether intravenously Mg attenuates HIOC-associated AKI | ||
650 | 4 | |a Randomized Controlled Trial | |
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700 | 1 | |a Feghali, Lea |e verfasserin |4 aut | |
700 | 1 | |a Devaraj, Nishant |e verfasserin |4 aut | |
700 | 1 | |a Hartigan, Philip M |e verfasserin |4 aut | |
700 | 1 | |a Yacoubian, Stephanie |e verfasserin |4 aut | |
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700 | 1 | |a Burke, Donna M |e verfasserin |4 aut | |
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700 | 1 | |a Bueno, Raphael |e verfasserin |4 aut | |
700 | 1 | |a Leaf, David E |e verfasserin |4 aut | |
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