Endocrine factors associated with infertility in women : an updated review
INTRODUCTION: Infertility is defined as the inability to conceive after unprotected sexual intercourse for at least 12 consecutive months. Our objective is to present an updated narrative review on the endocrine causes of infertility in women.
AREAS COVERED: A comprehensive review was conducted using Scielo, Scopus, and EMBASE databases, comprising 245 articles. The pathophysiology of infertility in women was described, including endocrinopathies such as hypothalamic amenorrhea, hyperprolactinemia, polycystic ovary syndrome, primary ovarian insufficiency, obesity, thyroid dysfunction, and adrenal disorders. The diagnostic approach was outlined, emphasizing the necessity of hormonal studies and ovarian response assessments. Additionally, the treatment plan was presented, commencing with non-pharmacological interventions, encompassing the adoption of a Mediterranean diet, vitamin supplementation, moderate exercise, and maintaining a healthy weight. Subsequently, pharmacological treatment was discussed, focusing on the management of associated endocrine disorders and ovulatory dysfunction.
EXPERT OPINION: This comprehensive review highlights the impact of endocrine disorders on fertility in women, providing diagnostic and therapeutic algorithms. Despite remaining knowledge gaps that hinder more effective treatments, ongoing research and advancements show promise for improved fertility success rates within the next five years. Enhanced comprehension of the pathophysiology behind endocrine causes and the progress in genetic research will facilitate the delivery of personalized treatments, thus enhancing fertility rates.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
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| Enthalten in: |
Expert review of endocrinology & metabolism - 18(2023), 5 vom: 13. Sept., Seite 399-417 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Concepción-Zavaleta, Marcio José [VerfasserIn] |
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| Links: |
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| Themen: |
Anovulation |
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| Anmerkungen: |
Date Completed 02.11.2023 Date Revised 14.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/17446651.2023.2256405 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM361996446 |
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| 500 | |a Date Revised 14.11.2023 | ||
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a INTRODUCTION: Infertility is defined as the inability to conceive after unprotected sexual intercourse for at least 12 consecutive months. Our objective is to present an updated narrative review on the endocrine causes of infertility in women | ||
| 520 | |a AREAS COVERED: A comprehensive review was conducted using Scielo, Scopus, and EMBASE databases, comprising 245 articles. The pathophysiology of infertility in women was described, including endocrinopathies such as hypothalamic amenorrhea, hyperprolactinemia, polycystic ovary syndrome, primary ovarian insufficiency, obesity, thyroid dysfunction, and adrenal disorders. The diagnostic approach was outlined, emphasizing the necessity of hormonal studies and ovarian response assessments. Additionally, the treatment plan was presented, commencing with non-pharmacological interventions, encompassing the adoption of a Mediterranean diet, vitamin supplementation, moderate exercise, and maintaining a healthy weight. Subsequently, pharmacological treatment was discussed, focusing on the management of associated endocrine disorders and ovulatory dysfunction | ||
| 520 | |a EXPERT OPINION: This comprehensive review highlights the impact of endocrine disorders on fertility in women, providing diagnostic and therapeutic algorithms. Despite remaining knowledge gaps that hinder more effective treatments, ongoing research and advancements show promise for improved fertility success rates within the next five years. Enhanced comprehension of the pathophysiology behind endocrine causes and the progress in genetic research will facilitate the delivery of personalized treatments, thus enhancing fertility rates | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Fertility | |
| 650 | 4 | |a anovulation | |
| 650 | 4 | |a female infertility | |
| 650 | 4 | |a hormones | |
| 650 | 4 | |a ovarian reserve | |
| 650 | 4 | |a reproductive health | |
| 700 | 1 | |a Coronado-Arroyo, Julia Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Quiroz-Aldave, Juan Eduardo |e verfasserin |4 aut | |
| 700 | 1 | |a Durand-Vásquez, María Del Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a Ildefonso-Najarro, Sofía Pilar |e verfasserin |4 aut | |
| 700 | 1 | |a Rafael-Robles, Luciana Del Pilar |e verfasserin |4 aut | |
| 700 | 1 | |a Concepción-Urteaga, Luis Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Gamarra-Osorio, Elman Rolando |e verfasserin |4 aut | |
| 700 | 1 | |a Suárez-Rojas, Jacsel |e verfasserin |4 aut | |
| 700 | 1 | |a Paz-Ibarra, José |e verfasserin |4 aut | |
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