Sex differences in vitamin D and behavioral profiles among children with allergic diseases
© 2023 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC..
Previous studies have suggested that vitamin D has a protective effect on allergic diseases, while an individual's sex may have a moderating effect on the relationship between vitamin D and allergic-related immunity. This study aimed to determine the role of vitamin D in children with coexisting allergic diseases in the context of sex differences and to explore the behavioral profiles of these patients. We recruited a total of 103 children with atopic diseases and divided them into four groups: males with one allergic disease (MA1, n = 20), males with two or more allergic diseases (MA2, n = 26), females with one allergic disease (FA1, n = 30), and females with two or more allergic diseases (FA2, n = 27). We measured serum calcium levels using the colorimetric method and serum 25-OH vitamin D total levels using electrochemiluminescence immunoassay. We found that MA2 had significantly lower vitamin D levels than MA1 and FA2. The levels of IgE were negatively correlated with vitamin D in females, whereas the levels of IgE were not significantly correlated with vitamin D in males. Furthermore, serum IgE was significantly correlated with children's adaptive skills, and different sexes were associated with different aspects of adaptive skills. Our findings suggest a protective role of vitamin D in the development of one allergic disease against the coexistence of allergic diseases in males, as well as extend the evidence for sex differences in immunity by demonstrating a sex-different correlation between IgE and vitamin D and the relationship between IgE and children's adaptive skills.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
---|---|
Enthalten in: |
Food science & nutrition - 11(2023), 9 vom: 14. Sept., Seite 5492-5500 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Li, Chia-Jung [VerfasserIn] |
---|
Links: |
---|
Themen: |
Allergic rhinitis |
---|
Anmerkungen: |
Date Revised 21.09.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
---|
doi: |
10.1002/fsn3.3505 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM361985673 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM361985673 | ||
003 | DE-627 | ||
005 | 20231226090309.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1002/fsn3.3505 |2 doi | |
028 | 5 | 2 | |a pubmed24n1206.xml |
035 | |a (DE-627)NLM361985673 | ||
035 | |a (NLM)37701228 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Li, Chia-Jung |e verfasserin |4 aut | |
245 | 1 | 0 | |a Sex differences in vitamin D and behavioral profiles among children with allergic diseases |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 21.09.2023 | ||
500 | |a published: Electronic-eCollection | ||
500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a © 2023 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC. | ||
520 | |a Previous studies have suggested that vitamin D has a protective effect on allergic diseases, while an individual's sex may have a moderating effect on the relationship between vitamin D and allergic-related immunity. This study aimed to determine the role of vitamin D in children with coexisting allergic diseases in the context of sex differences and to explore the behavioral profiles of these patients. We recruited a total of 103 children with atopic diseases and divided them into four groups: males with one allergic disease (MA1, n = 20), males with two or more allergic diseases (MA2, n = 26), females with one allergic disease (FA1, n = 30), and females with two or more allergic diseases (FA2, n = 27). We measured serum calcium levels using the colorimetric method and serum 25-OH vitamin D total levels using electrochemiluminescence immunoassay. We found that MA2 had significantly lower vitamin D levels than MA1 and FA2. The levels of IgE were negatively correlated with vitamin D in females, whereas the levels of IgE were not significantly correlated with vitamin D in males. Furthermore, serum IgE was significantly correlated with children's adaptive skills, and different sexes were associated with different aspects of adaptive skills. Our findings suggest a protective role of vitamin D in the development of one allergic disease against the coexistence of allergic diseases in males, as well as extend the evidence for sex differences in immunity by demonstrating a sex-different correlation between IgE and vitamin D and the relationship between IgE and children's adaptive skills | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a IgE | |
650 | 4 | |a allergic rhinitis | |
650 | 4 | |a asthma | |
650 | 4 | |a atopic dermatitis | |
650 | 4 | |a vitamin D | |
700 | 1 | |a Chang, Ling-Sai |e verfasserin |4 aut | |
700 | 1 | |a Guo, Mindy Ming-Huey |e verfasserin |4 aut | |
700 | 1 | |a Wang, Liang-Jen |e verfasserin |4 aut | |
700 | 1 | |a Kuo, Ho-Chang |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Food science & nutrition |d 2013 |g 11(2023), 9 vom: 14. Sept., Seite 5492-5500 |w (DE-627)NLM238025020 |x 2048-7177 |7 nnns |
773 | 1 | 8 | |g volume:11 |g year:2023 |g number:9 |g day:14 |g month:09 |g pages:5492-5500 |
856 | 4 | 0 | |u http://dx.doi.org/10.1002/fsn3.3505 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 11 |j 2023 |e 9 |b 14 |c 09 |h 5492-5500 |