Long term outcome and prognostic indicators in Posner Schlossman syndrome
© 2023 Royal Australian and New Zealand College of Ophthalmologists..
BACKGROUND: Posner Schlossman syndrome is a well-defined uveitis entity that is characterised by relapsing remitting unilateral anterior uveitis with markedly raised intraocular pressure. The aim of this study was to determine the risk factors for progression in patients with Posner Schlossman syndrome.
METHODS: Ninety-eight patients were enrolled in a retrospective case series. Progression was defined as a composite endpoint of any of development of permanent glaucoma (in patients with no evidence of glaucomatous loss on presentation), corneal failure, or chronic inflammation. Relapse was defined as a resolving episode of inflammation not meeting the criteria for progression.
RESULTS: Seventy seven percent of patients relapsed on average each 2.2 years. Forty percent of patients progressed. On univariate analysis, increased age at enrolment, immunocompromise at enrolment, the presence of glaucomatous optic neuropathy at enrolment, the performance of an anterior chamber tap and a positive anterior chamber tap were all associated with increased risk of progression. On multivariate analysis, age at enrolment, immunocompromise at enrolment, the performance of an anterior chamber tap, and the presence of glaucomatous optic neuropathy at enrolment were independently associated with increased risk of disease progression.
CONCLUSIONS: Posner Schlossman syndrome is not a benign uveitis entity and risk of both relapse and progression are high. Older patients, immunocompromised patients, patients with glaucomatous optic neuropathy at enrolment and those with a positive anterior chamber tap are all at increased risk of progression.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
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| Enthalten in: |
Clinical & experimental ophthalmology - 51(2023), 8 vom: 12. Nov., Seite 781-789 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Joseph, Danica M [VerfasserIn] |
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Date Completed 14.11.2023 Date Revised 22.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/ceo.14292 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Joseph, Danica M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Long term outcome and prognostic indicators in Posner Schlossman syndrome |
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| 500 | |a Date Revised 22.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 Royal Australian and New Zealand College of Ophthalmologists. | ||
| 520 | |a BACKGROUND: Posner Schlossman syndrome is a well-defined uveitis entity that is characterised by relapsing remitting unilateral anterior uveitis with markedly raised intraocular pressure. The aim of this study was to determine the risk factors for progression in patients with Posner Schlossman syndrome | ||
| 520 | |a METHODS: Ninety-eight patients were enrolled in a retrospective case series. Progression was defined as a composite endpoint of any of development of permanent glaucoma (in patients with no evidence of glaucomatous loss on presentation), corneal failure, or chronic inflammation. Relapse was defined as a resolving episode of inflammation not meeting the criteria for progression | ||
| 520 | |a RESULTS: Seventy seven percent of patients relapsed on average each 2.2 years. Forty percent of patients progressed. On univariate analysis, increased age at enrolment, immunocompromise at enrolment, the presence of glaucomatous optic neuropathy at enrolment, the performance of an anterior chamber tap and a positive anterior chamber tap were all associated with increased risk of progression. On multivariate analysis, age at enrolment, immunocompromise at enrolment, the performance of an anterior chamber tap, and the presence of glaucomatous optic neuropathy at enrolment were independently associated with increased risk of disease progression | ||
| 520 | |a CONCLUSIONS: Posner Schlossman syndrome is not a benign uveitis entity and risk of both relapse and progression are high. Older patients, immunocompromised patients, patients with glaucomatous optic neuropathy at enrolment and those with a positive anterior chamber tap are all at increased risk of progression | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a cytomegalovirus | |
| 650 | 4 | |a glaucoma | |
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| 700 | 1 | |a Samalia, Priya D |e verfasserin |4 aut | |
| 700 | 1 | |a Wells, Jane M |e verfasserin |4 aut | |
| 700 | 1 | |a McCluskey, Peter J |e verfasserin |4 aut | |
| 700 | 1 | |a Paul, Eldho |e verfasserin |4 aut | |
| 700 | 1 | |a Hall, Anthony J |e verfasserin |4 aut | |
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