Modulation of mi-RNA25/Ox-LDL/NOX4 signaling pathway by polyphenolic compound Hydroxytyrosol as a new avenue to alleviate cisplatin-induced acute kidney injury, a mechanistic study in rats
Copyright © 2023 Elsevier B.V. All rights reserved..
Acute kidney injury (AKI) caused by Cis is considered one of the most severe adverse effects, which restricts its use and efficacy. This study seeks to examine the potential reno-protective impact of phenolic compound Hydroxytyrosol (HT) against Cis-induced AKI and the possible involvement of the mi-RNA25/Ox-LDL/NOX4 pathway elucidating the probable implicated molecular mechanisms. Forty rats were placed into 5 groups. Group I received saline only. Group II received Cis only. Group III, IV, and V received 20, 50, and 100 mg/kg b.w, of HT, respectively, with Cis delivery. NOX4, Ox-LDL, and gene expression of mi-RNA 25, TNF-α, and HO-1 in renal tissue were detected. HT showed reno-protective effect and significantly upregulated mi-RNA 25 and HO-1 as well as decreased the expression of NOX4, Ox-LDL, and TNF-α. In conclusion, HT may be promising in the fight against Cis-induced AKI through modulation of mi-RNA25/Ox-LDL/NOX4 pathway.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:103 |
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| Enthalten in: |
Environmental toxicology and pharmacology - 103(2023) vom: 01. Okt., Seite 104262 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ewees, Mohamed Gamal El-Din [VerfasserIn] |
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| Links: |
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| Themen: |
HO-1 and FOXO3a |
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| Anmerkungen: |
Date Revised 12.10.2023 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.etap.2023.104262 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM361968043 |
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| 245 | 1 | 0 | |a Modulation of mi-RNA25/Ox-LDL/NOX4 signaling pathway by polyphenolic compound Hydroxytyrosol as a new avenue to alleviate cisplatin-induced acute kidney injury, a mechanistic study in rats |
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| 520 | |a Copyright © 2023 Elsevier B.V. All rights reserved. | ||
| 520 | |a Acute kidney injury (AKI) caused by Cis is considered one of the most severe adverse effects, which restricts its use and efficacy. This study seeks to examine the potential reno-protective impact of phenolic compound Hydroxytyrosol (HT) against Cis-induced AKI and the possible involvement of the mi-RNA25/Ox-LDL/NOX4 pathway elucidating the probable implicated molecular mechanisms. Forty rats were placed into 5 groups. Group I received saline only. Group II received Cis only. Group III, IV, and V received 20, 50, and 100 mg/kg b.w, of HT, respectively, with Cis delivery. NOX4, Ox-LDL, and gene expression of mi-RNA 25, TNF-α, and HO-1 in renal tissue were detected. HT showed reno-protective effect and significantly upregulated mi-RNA 25 and HO-1 as well as decreased the expression of NOX4, Ox-LDL, and TNF-α. In conclusion, HT may be promising in the fight against Cis-induced AKI through modulation of mi-RNA25/Ox-LDL/NOX4 pathway | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a HO-1 and FOXO3a | |
| 650 | 4 | |a Hydroxytyrosol | |
| 650 | 4 | |a Mi-RNA 25 | |
| 650 | 4 | |a NOX4 | |
| 650 | 4 | |a Ox-LDL | |
| 700 | 1 | |a Orfali, Raha |e verfasserin |4 aut | |
| 700 | 1 | |a Rateb, Enas Ezzat |e verfasserin |4 aut | |
| 700 | 1 | |a Hassan, Hossam M |e verfasserin |4 aut | |
| 700 | 1 | |a Hozzein, Wael N |e verfasserin |4 aut | |
| 700 | 1 | |a Alkhalfah, Dalal Hussien M |e verfasserin |4 aut | |
| 700 | 1 | |a Sree, Haidy Tamer Abo |e verfasserin |4 aut | |
| 700 | 1 | |a Abdel Rahman, Fatema El-Zahraa S |e verfasserin |4 aut | |
| 700 | 1 | |a Rateb, Mostafa E |e verfasserin |4 aut | |
| 700 | 1 | |a Mahmoud, Nesreen Ishak |e verfasserin |4 aut | |
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