Synthesis of amphiphilic hydantoin-based universal peptidomimetics as antibiotic agents
Three model hydantoin-based universal peptidomimetics were designed and synthetized. Their preferred amphiphilic β-turn conformation was assessed using molecular modeling and NMR experiments, and their antibacterial activity was tested against Gram-positive and Gram-negative bacteria strains, which demonstrated that these compounds could be a captivating class of antibiotics to fight emergent drug resistance.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
|---|---|
| Enthalten in: |
Organic & biomolecular chemistry - 21(2023), 38 vom: 04. Okt., Seite 7702-7706 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Caramiello, Alessio M [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Revised 04.10.2023 published: Electronic Citation Status Publisher |
|---|
| doi: |
10.1039/d3ob01247f |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM361959753 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM361959753 | ||
| 003 | DE-627 | ||
| 005 | 20231226090237.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1039/d3ob01247f |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1206.xml |
| 035 | |a (DE-627)NLM361959753 | ||
| 035 | |a (NLM)37698587 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Caramiello, Alessio M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Synthesis of amphiphilic hydantoin-based universal peptidomimetics as antibiotic agents |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 04.10.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Three model hydantoin-based universal peptidomimetics were designed and synthetized. Their preferred amphiphilic β-turn conformation was assessed using molecular modeling and NMR experiments, and their antibacterial activity was tested against Gram-positive and Gram-negative bacteria strains, which demonstrated that these compounds could be a captivating class of antibiotics to fight emergent drug resistance | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Bellucci, Maria Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Ottaviano, Emerenziana |e verfasserin |4 aut | |
| 700 | 1 | |a Ancona, Silvia |e verfasserin |4 aut | |
| 700 | 1 | |a Borghi, Elisa |e verfasserin |4 aut | |
| 700 | 1 | |a Volonterio, Alessandro |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Organic & biomolecular chemistry |d 2003 |g 21(2023), 38 vom: 04. Okt., Seite 7702-7706 |w (DE-627)NLM126779694 |x 1477-0539 |7 nnns |
| 773 | 1 | 8 | |g volume:21 |g year:2023 |g number:38 |g day:04 |g month:10 |g pages:7702-7706 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1039/d3ob01247f |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 21 |j 2023 |e 38 |b 04 |c 10 |h 7702-7706 | ||