Interleukin-34 is more suitable than macrophage colony-stimulating factor for predicting liver significant fibrosis in patients with chronic hepatitis B
AIMS: Interleukin-34 (IL-34) and macrophage colony-stimulating factor (CSF-1) have similar functions, such as promoting the formation of liver fibrosis. This study aimed to evaluate and compare the diagnostic value of serum IL-34 and CSF-1 for significant liver fibrosis in patients with chronic hepatitis B (CHB).
METHODS: A total of 369 CHB patients, consisting of 208 HBeAg-negative patients and 161 HBeAg-positive patients, were enrolled in this study. Additionally, 72 healthy individuals served as healthy controls (HCs). Serum levels of IL-34 and CSF-1 were measured using the enzyme-linked immunosorbent assay method. Liver fibrosis grades were assessed using the modified Scheuer scoring system.
RESULTS: Serum IL-34 and CSF-1 levels exhibited significant elevation in both HBeAg-negative and HBeAg-positive patients in comparison to HCs (p < 0.001). IL-34 emerged as an independent factor linked to significant liver fibrosis, whereas CSF-1 did not exhibit such an association. Receiver operating characteristic (ROC) analysis indicated higher areas under the curves (AUCs) for IL-34 (0.814, p < 0.001 and 0.673, p < 0.001) when diagnosing significant liver fibrosis in HBeAg-negative and HBeAg-positive patients, respectively, as opposed to CSF-1 (0.602, p < 0.001; 0.619, p = 0.385). Within the HBeAg-negative patient subgroup, the AUC for IL-34 surpassed that of FIB-4 (p = 0.009) and APRI (p = 0.045).
CONCLUSION: Serum IL-34 has the potential to be a straightforward and practical biomarker that demonstrates superior performance to serum CSF-1 in the diagnosis of significant liver fibrosis in CHB patients, especially within the HBeAg-negative patients.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 2023 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:59 |
---|---|
Enthalten in: |
Scandinavian journal of gastroenterology - 59(2023), 1 vom: 01. Jan., Seite 78-84 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Yang, Kai [VerfasserIn] |
---|
Links: |
---|
Themen: |
81627-83-0 |
---|
Anmerkungen: |
Date Completed 27.12.2023 Date Revised 27.12.2023 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1080/00365521.2023.2254438 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM361956975 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM361956975 | ||
003 | DE-627 | ||
005 | 20231229124134.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1080/00365521.2023.2254438 |2 doi | |
028 | 5 | 2 | |a pubmed24n1241.xml |
035 | |a (DE-627)NLM361956975 | ||
035 | |a (NLM)37698305 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Yang, Kai |e verfasserin |4 aut | |
245 | 1 | 0 | |a Interleukin-34 is more suitable than macrophage colony-stimulating factor for predicting liver significant fibrosis in patients with chronic hepatitis B |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 27.12.2023 | ||
500 | |a Date Revised 27.12.2023 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a AIMS: Interleukin-34 (IL-34) and macrophage colony-stimulating factor (CSF-1) have similar functions, such as promoting the formation of liver fibrosis. This study aimed to evaluate and compare the diagnostic value of serum IL-34 and CSF-1 for significant liver fibrosis in patients with chronic hepatitis B (CHB) | ||
520 | |a METHODS: A total of 369 CHB patients, consisting of 208 HBeAg-negative patients and 161 HBeAg-positive patients, were enrolled in this study. Additionally, 72 healthy individuals served as healthy controls (HCs). Serum levels of IL-34 and CSF-1 were measured using the enzyme-linked immunosorbent assay method. Liver fibrosis grades were assessed using the modified Scheuer scoring system | ||
520 | |a RESULTS: Serum IL-34 and CSF-1 levels exhibited significant elevation in both HBeAg-negative and HBeAg-positive patients in comparison to HCs (p < 0.001). IL-34 emerged as an independent factor linked to significant liver fibrosis, whereas CSF-1 did not exhibit such an association. Receiver operating characteristic (ROC) analysis indicated higher areas under the curves (AUCs) for IL-34 (0.814, p < 0.001 and 0.673, p < 0.001) when diagnosing significant liver fibrosis in HBeAg-negative and HBeAg-positive patients, respectively, as opposed to CSF-1 (0.602, p < 0.001; 0.619, p = 0.385). Within the HBeAg-negative patient subgroup, the AUC for IL-34 surpassed that of FIB-4 (p = 0.009) and APRI (p = 0.045) | ||
520 | |a CONCLUSION: Serum IL-34 has the potential to be a straightforward and practical biomarker that demonstrates superior performance to serum CSF-1 in the diagnosis of significant liver fibrosis in CHB patients, especially within the HBeAg-negative patients | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a CHB | |
650 | 4 | |a IL-34 | |
650 | 4 | |a csf-1 | |
650 | 4 | |a liver fibrosis | |
650 | 4 | |a prediction | |
650 | 7 | |a Hepatitis B e Antigens |2 NLM | |
650 | 7 | |a Interleukins |2 NLM | |
650 | 7 | |a Macrophage Colony-Stimulating Factor |2 NLM | |
650 | 7 | |a 81627-83-0 |2 NLM | |
650 | 7 | |a IL34 protein, human |2 NLM | |
700 | 1 | |a Ying, Pan |e verfasserin |4 aut | |
700 | 1 | |a Sun, Beibei |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Scandinavian journal of gastroenterology |d 1966 |g 59(2023), 1 vom: 01. Jan., Seite 78-84 |w (DE-627)NLM000055166 |x 1502-7708 |7 nnns |
773 | 1 | 8 | |g volume:59 |g year:2023 |g number:1 |g day:01 |g month:01 |g pages:78-84 |
856 | 4 | 0 | |u http://dx.doi.org/10.1080/00365521.2023.2254438 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 59 |j 2023 |e 1 |b 01 |c 01 |h 78-84 |